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Items: 1 to 20 of 98

1.

A post-synthetic approach for the synthesis of 2'-O-methyldithiomethyl-modified oligonucleotides responsive to a reducing environment.

Ochi Y, Nakagawa O, Sakaguchi K, Wada S, Urata H.

Chem Commun (Camb). 2013 Sep 7;49(69):7620-2. doi: 10.1039/c3cc43725f. Epub 2013 Jul 19.

PMID:
23872984
2.

A New Nucleic Acid Prodrug Responsive to High Thiol Concentration: Synthesis of 2'-O-Methyldithiomethyl-Modified Oligonucleotides by Post-Synthetic Modification.

Ochi Y, Nakagawa O, Hayashi J, Wada S, Urata H.

Curr Protoc Nucleic Acid Chem. 2015 Sep 1;62:4.63.1-20. doi: 10.1002/0471142700.nc0463s62.

PMID:
26380903
3.

Gene silencing by 2'-O-methyldithiomethyl-modified siRNA, a prodrug-type siRNA responsive to reducing environment.

Ochi Y, Imai M, Nakagawa O, Hayashi J, Wada SI, Urata H.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):845-848. doi: 10.1016/j.bmcl.2015.12.074. Epub 2015 Dec 22.

PMID:
26755395
4.

Syntheses of prodrug-type phosphotriester oligonucleotides responsive to intracellular reducing environment for improvement of cell membrane permeability and nuclease resistance.

Hayashi J, Samezawa Y, Ochi Y, Wada SI, Urata H.

Bioorg Med Chem Lett. 2017 Jul 15;27(14):3135-3138. doi: 10.1016/j.bmcl.2017.05.031. Epub 2017 May 11.

PMID:
28532670
5.

Synthesis and hybridization property of sugar and phosphate linkage modified oligonucleotides.

Jeong LS, Lee JH, Jung KE, Moon HR, Kim K, Lim H.

Bioorg Med Chem. 1999 Jul;7(7):1467-73.

PMID:
10465421
6.

Stabilization of double-stranded oligonucleotides using backbone-linked disulfide bridges.

Gao H, Yang M, Cook AF.

Nucleic Acids Res. 1995 Jan 25;23(2):285-92.

7.

Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics.

Zhou C, Chattopadhyaya J.

Chem Rev. 2012 Jul 11;112(7):3808-32. doi: 10.1021/cr100306q. Epub 2012 Apr 24. Review. No abstract available.

PMID:
22530946
8.

First synthesis of fully modified 4'-selenoRNA and 2'-OMe-4'-selenoRNA based on the mechanistic considerations of an unexpected strand break.

Tarashima N, Hayashi K, Terasaki M, Taniike H, Inagaki Y, Hirose K, Furukawa K, Matsuda A, Minakawa N.

Org Lett. 2014 Sep 19;16(18):4710-3. doi: 10.1021/ol502077h. Epub 2014 Sep 2.

PMID:
25181546
9.

Rapid routes of synthesis of chemically reactive and highly radioactively labeled alpha- and beta-oligonucleotide derivatives for in vivo studies.

Boutorine AS, Le Doan T, Battioni JP, Mansuy D, Dupré D, Hélène C.

Bioconjug Chem. 1990 Sep-Oct;1(5):350-6.

PMID:
1965883
10.

Synthesis of 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides.

Prakash TP, Kawasaki AM, Fraser AS, Vasquez G, Manoharan M.

J Org Chem. 2002 Jan 25;67(2):357-69.

PMID:
11798305
11.

Approach to the synthesis of natural and modified oligonucleotides by the phosphotriester method using O-nucleophilic intramolecular catalysis.

Efimov VA, Molchanova NS, Chakhmakhcheva OG.

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1087-93.

PMID:
18058542
12.

Chimeric RNA with modified backbones: alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2'-OH and 2'-OMe groups.

Prhavc M, Bhat B, Just G, Cook PD, Manoharan M.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):995-7.

PMID:
11563162
13.

One-electron reductive template-directed ligation of oligodeoxynucleotides possessing a disulfide bond.

Tanabe K, Kuraseko E, Yamamoto Y, Nishimoto S.

J Am Chem Soc. 2008 May 21;130(20):6302-3. doi: 10.1021/ja7111614. Epub 2008 Apr 29.

PMID:
18444625
14.

Synthesis and properties of 2'-O,4'-C-ethyleneoxy bridged 5-methyluridine.

Hari Y, Morikawa T, Osawa T, Obika S.

Org Lett. 2013 Jul 19;15(14):3702-5. doi: 10.1021/ol401566r. Epub 2013 Jul 1.

PMID:
23815244
15.

2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures.

Prakash TP, Püschl A, Lesnik E, Mohan V, Tereshko V, Egli M, Manoharan M.

Org Lett. 2004 Jun 10;6(12):1971-4.

PMID:
15176796
16.

Phosphorylating reagent-free synthesis of 5'-phosphate oligonucleotides by controlled oxidative degradation of their 5'-end.

Sallamand C, Miscioscia A, Lartia R, Defrancq E.

Org Lett. 2012 Apr 20;14(8):2030-3. doi: 10.1021/ol300542s. Epub 2012 Apr 5.

PMID:
22480332
17.

Solid phase synthesis of phosphorothioate oligonucleotides utilizing diethyldithiocarbonate disulfide (DDD) as an efficient sulfur transfer reagent.

Cheruvallath ZS, Kumar RK, Rentel C, Cole DL, Ravikumar VT.

Nucleosides Nucleotides Nucleic Acids. 2003 Apr;22(4):461-8.

PMID:
12885126
19.

An improved method for the synthesis and deprotection of methylphosphonate oligonucleotides.

Hogrefe RI, Reynolds MA, Vaghefi MM, Young KM, Riley TA, Klem RE, Arnold LJ Jr.

Methods Mol Biol. 1993;20:143-64.

PMID:
8242134
20.

Oligonucleotide N3'-->P5' phosphoramidates.

Gryaznov SM, Lloyd DH, Chen JK, Schultz RG, DeDionisio LA, Ratmeyer L, Wilson WD.

Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5798-802.

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