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miR-21 coordinates tumor growth and modulates KRIT1 levels.

Orso F, Balzac F, Marino M, Lembo A, Retta SF, Taverna D.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):90-6. doi: 10.1016/j.bbrc.2013.07.031. Epub 2013 Jul 18.


Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling.

Glading AJ, Ginsberg MH.

Dis Model Mech. 2010 Jan-Feb;3(1-2):73-83. doi: 10.1242/dmm.003293. Epub 2009 Dec 9.


Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).

Li X, Zhang R, Draheim KM, Liu W, Calderwood DA, Boggon TJ.

J Biol Chem. 2012 Jun 22;287(26):22317-27. doi: 10.1074/jbc.M112.361295. Epub 2012 May 10.


Identification of Krit1B: a novel alternative splicing isoform of cerebral cavernous malformation gene-1.

Retta SF, Avolio M, Francalanci F, Procida S, Balzac F, Degani S, Tarone G, Silengo L.

Gene. 2004 Jan 21;325:63-78.


Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1).

Kehrer-Sawatzki H, Wilda M, Braun VM, Richter HP, Hameister H.

Acta Neuropathol. 2002 Sep;104(3):231-40. Epub 2002 Jun 26.


MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer.

Guo QJ, Mills JN, Bandurraga SG, Nogueira LM, Mason NJ, Camp ER, Larue AC, Turner DP, Findlay VJ.

Breast Cancer Res. 2013;15(4):R70.


Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations.

Fisher OS, Liu W, Zhang R, Stiegler AL, Ghedia S, Weber JL, Boggon TJ.

J Biol Chem. 2015 Jan 30;290(5):2842-53. doi: 10.1074/jbc.M114.616433. Epub 2014 Dec 18.


MicroRNA-1185 Induces Endothelial Cell Apoptosis by Targeting UVRAG and KRIT1.

Deng H, Chu X, Song Z, Deng X, Xu H, Ye Y, Li S, Zhang Q, Sun C, Li Y.

Cell Physiol Biochem. 2017;41(6):2171-2182. doi: 10.1159/000475571. Epub 2017 Apr 20.


KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

Goitre L, Balzac F, Degani S, Degan P, Marchi S, Pinton P, Retta SF.

PLoS One. 2010 Jul 26;5(7):e11786. doi: 10.1371/journal.pone.0011786.


A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions.

Liu JJ, Stockton RA, Gingras AR, Ablooglu AJ, Han J, Bobkov AA, Ginsberg MH.

Mol Biol Cell. 2011 Jul 15;22(14):2509-19. doi: 10.1091/mbc.E11-02-0157. Epub 2011 Jun 1.


KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein.

Gunel M, Laurans MS, Shin D, DiLuna ML, Voorhees J, Choate K, Nelson-Williams C, Lifton RP.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10677-82. Epub 2002 Jul 24.


Krev1 interaction trapped-1/cerebral cavernous malformation-1 protein expression during early angiogenesis.

Guzeloglu-Kayisli O, Kayisli UA, Amankulor NM, Voorhees JR, Gokce O, DiLuna ML, Laurans MS, Luleci G, Gunel M.

J Neurosurg. 2004 May;100(5 Suppl Pediatrics):481-7.


Spectrum and expression analysis of KRIT1 mutations in 121 consecutive and unrelated patients with Cerebral Cavernous Malformations.

Cavé-Riant F, Denier C, Labauge P, Cécillon M, Maciazek J, Joutel A, Laberge-Le Couteulx S, Tournier-Lasserve E.

Eur J Hum Genet. 2002 Nov;10(11):733-40.


Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations.

Zhang J, Rigamonti D, Dietz HC, Clatterbuck RE.

Neurosurgery. 2007 Feb;60(2):353-9; discussion 359.


The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail.

Gingras AR, Puzon-McLaughlin W, Ginsberg MH.

J Biol Chem. 2013 Aug 16;288(33):23639-49. doi: 10.1074/jbc.M113.462911. Epub 2013 Jun 27.


ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis.

Herberich SE, Klose R, Moll I, Yang WJ, Wüstehube-Lausch J, Fischer A.

PLoS One. 2015 Dec 23;10(12):e0145304. doi: 10.1371/journal.pone.0145304. eCollection 2015.


KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.

Zawistowski JS, Serebriiskii IG, Lee MF, Golemis EA, Marchuk DA.

Hum Mol Genet. 2002 Feb 15;11(4):389-96.


KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun.

Goitre L, De Luca E, Braggion S, Trapani E, Guglielmotto M, Biasi F, Forni M, Moglia A, Trabalzini L, Retta SF.

Free Radic Biol Med. 2014 Mar;68:134-47. doi: 10.1016/j.freeradbiomed.2013.11.020. Epub 2013 Nov 28.


A comprehensive search for microRNAs with expression profiles modulated by oncogenic KRAS: potential involvement of miR-31 in lung carcinogenesis.

Okudela K, Suzuki T, Umeda S, Tateishi Y, Mitsui H, Miyagi Y, Ohashi K.

Oncol Rep. 2014 Oct;32(4):1374-84. doi: 10.3892/or.2014.3339. Epub 2014 Jul 18.


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