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Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1.

Zhang H, Nestor CE, Zhao S, Lentini A, Bohle B, Benson M, Wang H.

J Allergy Clin Immunol. 2013 Oct;132(4):1005-8. doi: 10.1016/j.jaci.2013.05.033. No abstract available.


Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.

Nawijn MC, Dingjan GM, Ferreira R, Lambrecht BN, Karis A, Grosveld F, Savelkoul H, Hendriks RW.

J Immunol. 2001 Jul 15;167(2):724-32.


Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions.

Eger KA, Sundrud MS, Motsinger AA, Tseng M, Van Kaer L, Unutmaz D.

PLoS One. 2006 Dec 20;1:e50.


Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types.

Wei G, Abraham BJ, Yagi R, Jothi R, Cui K, Sharma S, Narlikar L, Northrup DL, Tang Q, Paul WE, Zhu J, Zhao K.

Immunity. 2011 Aug 26;35(2):299-311. doi: 10.1016/j.immuni.2011.08.007.


CD4+ Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene.

Ankathatti Munegowda M, Xu S, Freywald A, Xiang J.

Mol Immunol. 2012 Jun;51(2):143-9. doi: 10.1016/j.molimm.2012.02.120.


Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.

Hu G, Tang Q, Sharma S, Yu F, Escobar TM, Muljo SA, Zhu J, Zhao K.

Nat Immunol. 2013 Nov;14(11):1190-8. doi: 10.1038/ni.2712.


Generation of human T helper 1 and T helper 2 subsets from peripheral blood-derived naive CD4+ T cells.

Palmer EM, Semnani RT, McRae BL, van Seventer GA.

Methods Mol Biol. 2000;134:325-35. No abstract available.


Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response.

Couto Alves A, Bruhn S, Ramasamy A, Wang H, Holloway JW, Hartikainen AL, Jarvelin MR, Benson M, Balding DJ, Coin LJ.

PLoS One. 2013 Oct 8;8(10):e74821. doi: 10.1371/journal.pone.0074821.


CD4 T cells: fates, functions, and faults.

Zhu J, Paul WE.

Blood. 2008 Sep 1;112(5):1557-69. doi: 10.1182/blood-2008-05-078154. Review.


The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.

Kohu K, Ohmori H, Wong WF, Onda D, Wakoh T, Kon S, Yamashita M, Nakayama T, Kubo M, Satake M.

J Immunol. 2009 Dec 15;183(12):7817-24. doi: 10.4049/jimmunol.0802527.


Inhibition of Th2 differentiation and GATA-3 expression by BCL-6.

Kusam S, Toney LM, Sato H, Dent AL.

J Immunol. 2003 Mar 1;170(5):2435-41.


PU.1 regulates TCR expression by modulating GATA-3 activity.

Chang HC, Han L, Jabeen R, Carotta S, Nutt SL, Kaplan MH.

J Immunol. 2009 Oct 15;183(8):4887-94. doi: 10.4049/jimmunol.0900363.


Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation.

Noben-Trauth N, Hu-Li J, Paul WE.

J Immunol. 2000 Oct 1;165(7):3620-5.


Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

Hegazy AN, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, Flatz L, Pinschewer DD, Radbruch A, Löhning M.

Immunity. 2010 Jan 29;32(1):116-28. doi: 10.1016/j.immuni.2009.12.004.


T(H)2 bias: Mina tips the balance.

Hemmers S, Mowen KA.

Nat Immunol. 2009 Aug;10(8):806-8. doi: 10.1038/ni0809-806. No abstract available.


Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation.

Sundrud MS, Grill SM, Ni D, Nagata K, Alkan SS, Subramaniam A, Unutmaz D.

J Immunol. 2003 Oct 1;171(7):3542-9.


c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development.

Nakata Y, Brignier AC, Jin S, Shen Y, Rudnick SI, Sugita M, Gewirtz AM.

Blood. 2010 Aug 26;116(8):1280-90. doi: 10.1182/blood-2009-05-223255.


Identification of novel IL-4/Stat6-regulated genes in T lymphocytes.

Chen Z, Lund R, Aittokallio T, Kosonen M, Nevalainen O, Lahesmaa R.

J Immunol. 2003 Oct 1;171(7):3627-35.


ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling.

Watanabe M, Watanabe S, Hara Y, Harada Y, Kubo M, Tanabe K, Toma H, Abe R.

J Immunol. 2005 Feb 15;174(4):1989-96.


Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis.

Bruhn S, Barrenäs F, Mobini R, Andersson BA, Chavali S, Egan BS, Hovig E, Sandve GK, Langston MA, Rogers G, Wang H, Benson M.

Allergy. 2012 Jan;67(1):33-40. doi: 10.1111/j.1398-9995.2011.02707.x.

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