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Compartmentalized protective and detrimental effects of endogenous macrophage migration-inhibitory factor mediated by CXCR2 in a mouse model of myocardial ischemia/reperfusion.

Liehn EA, Kanzler I, Konschalla S, Kroh A, Simsekyilmaz S, Sönmez TT, Bucala R, Bernhagen J, Weber C.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2180-6. doi: 10.1161/ATVBAHA.113.301633. Epub 2013 Jul 18.


Limiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction.

Wang J, Tong C, Yan X, Yeung E, Gandavadi S, Hare AA, Du X, Chen Y, Xiong H, Ma C, Leng L, Young LH, Jorgensen WL, Li J, Bucala R.

Circulation. 2013 Jul 16;128(3):225-36. doi: 10.1161/CIRCULATIONAHA.112.000862. Epub 2013 Jun 10.


Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction.

White DA, Su Y, Kanellakis P, Kiriazis H, Morand EF, Bucala R, Dart AM, Gao XM, Du XJ.

J Mol Cell Cardiol. 2014 Apr;69:32-42. doi: 10.1016/j.yjmcc.2014.01.015. Epub 2014 Feb 5.


Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion.

Qi D, Hu X, Wu X, Merk M, Leng L, Bucala R, Young LH.

J Clin Invest. 2009 Dec;119(12):3807-16. doi: 10.1172/JCI39738. Epub 2009 Nov 16.


Targeted intracellular accumulation of macrophage migration inhibitory factor in the reperfused heart mediates cardioprotection.

Pohl J, Hendgen-Cotta UB, Rammos C, Luedike P, Mull E, Stoppe C, Jülicher K, Lue H, Merx MW, Kelm M, Bernhagen J, Rassaf T.

Thromb Haemost. 2016 Jan;115(1):200-12. doi: 10.1160/TH15-05-0436. Epub 2015 Aug 27.


Opposing effects mediated by the chemokine receptor CXCR2 on myocardial ischemia-reperfusion injury: recruitment of potentially damaging neutrophils and direct myocardial protection.

Tarzami ST, Miao W, Mani K, Lopez L, Factor SM, Berman JW, Kitsis RN.

Circulation. 2003 Nov 11;108(19):2387-92. Epub 2003 Oct 20.


Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells.

Xia W, Zhang F, Xie C, Jiang M, Hou M.

Stem Cell Res Ther. 2015 Apr 22;6:82. doi: 10.1186/s13287-015-0076-3.


Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation.

Gao XM, Liu Y, White D, Su Y, Drew BG, Bruce CR, Kiriazis H, Xu Q, Jennings N, Bobik A, Febbraio MA, Kingwell BA, Bucala R, Fingerle-Rowson G, Dart AM, Morand EF, Du XJ.

J Mol Cell Cardiol. 2011 Jun;50(6):991-9. doi: 10.1016/j.yjmcc.2010.12.022. Epub 2011 Jan 6.


Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+ NKT cells in chemically induced IFN-γ-mediated skin inflammation.

Hsieh CY, Chen CL, Lin YS, Yeh TM, Tsai TT, Hong MY, Lin CF.

J Immunol. 2014 Oct 1;193(7):3693-703. doi: 10.4049/jimmunol.1400692. Epub 2014 Aug 29.


MIF, CD74 and other partners in kidney disease: tales of a promiscuous couple.

Sanchez-Niño MD, Sanz AB, Ruiz-Andres O, Poveda J, Izquierdo MC, Selgas R, Egido J, Ortiz A.

Cytokine Growth Factor Rev. 2013 Feb;24(1):23-40. doi: 10.1016/j.cytogfr.2012.08.001. Epub 2012 Sep 7. Review.


Impaired macrophage migration inhibitory factor-AMP-activated protein kinase activation and ischemic recovery in the senescent heart.

Ma H, Wang J, Thomas DP, Tong C, Leng L, Wang W, Merk M, Zierow S, Bernhagen J, Ren J, Bucala R, Li J.

Circulation. 2010 Jul 20;122(3):282-92. doi: 10.1161/CIRCULATIONAHA.110.953208. Epub 2010 Jul 6.


Migration inhibitory factor enhances inflammation via CD74 in cartilage end plates with Modic type 1 changes on MRI.

Xiong C, Huang B, Cun Y, Aghdasi BG, Zhou Y.

Clin Orthop Relat Res. 2014 Jun;472(6):1943-54. doi: 10.1007/s11999-014-3508-y. Epub 2014 Feb 26.


MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling.

Klasen C, Ohl K, Sternkopf M, Shachar I, Schmitz C, Heussen N, Hobeika E, Levit-Zerdoun E, Tenbrock K, Reth M, Bernhagen J, El Bounkari O.

J Immunol. 2014 Jun 1;192(11):5273-84. doi: 10.4049/jimmunol.1302209. Epub 2014 Apr 23.


Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone mass.

Mun SH, Won HY, Hernandez P, Aguila HL, Lee SK.

J Bone Miner Res. 2013 Apr;28(4):948-59. doi: 10.1002/jbmr.1787.


Macrophage migration inhibitory factor antagonizes pressure overload-induced cardiac hypertrophy.

Koga K, Kenessey A, Ojamaa K.

Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H282-93. doi: 10.1152/ajpheart.00595.2012. Epub 2012 Nov 9.


MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics.

Tilstam PV, Qi D, Leng L, Young L, Bucala R.

Expert Opin Ther Targets. 2017 Jul;21(7):671-683. doi: 10.1080/14728222.2017.1336227. Review.


MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism.

Kraemer S, Lue H, Zernecke A, Kapurniotu A, Andreetto E, Frank R, Lennartz B, Weber C, Bernhagen J.

FASEB J. 2011 Mar;25(3):894-906. doi: 10.1096/fj.10-168559. Epub 2010 Nov 24.


Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74.

Heinrichs D, Knauel M, Offermanns C, Berres ML, Nellen A, Leng L, Schmitz P, Bucala R, Trautwein C, Weber C, Bernhagen J, Wasmuth HE.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17444-9. doi: 10.1073/pnas.1107023108. Epub 2011 Oct 3.


Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74.

Lue H, Dewor M, Leng L, Bucala R, Bernhagen J.

Cell Signal. 2011 Jan;23(1):135-44. doi: 10.1016/j.cellsig.2010.08.013. Epub 2010 Aug 31.


MIF inhibits monocytic movement through a non-canonical receptor and disruption of temporal Rho GTPase activities in U-937 cells.

DiCosmo-Ponticello CJ, Hoover D, Coffman FD, Cohen S, Cohen MC.

Cytokine. 2014 Sep;69(1):47-55. doi: 10.1016/j.cyto.2014.05.005. Epub 2014 Jun 6.


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