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Items: 1 to 20 of 143

1.

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.

Yang W, Wang J, Moore DC, Liang H, Dooner M, Wu Q, Terek R, Chen Q, Ehrlich MG, Quesenberry PJ, Neel BG.

Nature. 2013 Jul 25;499(7459):491-5. doi: 10.1038/nature12396. Epub 2013 Jul 17.

2.

SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates.

Bowen ME, Ayturk UM, Kurek KC, Yang W, Warman ML.

PLoS Genet. 2014 May 29;10(5):e1004364. doi: 10.1371/journal.pgen.1004364. eCollection 2014.

3.

Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions.

Kim HK, Feng GS, Chen D, King PD, Kamiya N.

J Bone Miner Res. 2014 Mar;29(3):761-9. doi: 10.1002/jbmr.2062.

4.

Cell biology: tumour stem cells in bone.

Zaidi M, Méndez-Ferrer S.

Nature. 2013 Jul 25;499(7459):414-6. doi: 10.1038/nature12412. Epub 2013 Jul 17. No abstract available.

5.
6.

Exostoses, enchondromatosis and metachondromatosis; diagnosis and management.

McFarlane J, Knight T, Sinha A, Cole T, Kiely N, Freeman R.

Acta Orthop Belg. 2016 Mar;82(1):102-5.

PMID:
26984661
7.

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.

Dong L, Yu WM, Zheng H, Loh ML, Bunting ST, Pauly M, Huang G, Zhou M, Broxmeyer HE, Scadden DT, Qu CK.

Nature. 2016 Nov 10;539(7628):304-308. doi: 10.1038/nature20131. Epub 2016 Oct 26.

8.
9.

Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.

Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG.

Circulation. 2008 Mar 18;117(11):1423-35. doi: 10.1161/CIRCULATIONAHA.107.728865. Epub 2008 Mar 3. Erratum in: Circulation.2008 Apr 15;117(15) e314.

10.

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.

De Rocca Serra-Nédélec A, Edouard T, Tréguer K, Tajan M, Araki T, Dance M, Mus M, Montagner A, Tauber M, Salles JP, Valet P, Neel BG, Raynal P, Yart A.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4257-62. doi: 10.1073/pnas.1119803109. Epub 2012 Feb 27.

11.

Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways.

Karp SJ, Schipani E, St-Jacques B, Hunzelman J, Kronenberg H, McMahon AP.

Development. 2000 Feb;127(3):543-8.

12.

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, Neel BG.

Blood. 2009 Apr 30;113(18):4414-24. doi: 10.1182/blood-2008-10-182626. Epub 2009 Jan 29.

13.

Chondrosarcoma in Metachondromatosis: A Rare Case Report.

Jamshidi K, Shooshtarizadeh T, Bahrabadi M.

Acta Med Iran. 2017 Dec;55(12):793-799.

14.

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.

Amano K, Densmore MJ, Lanske B.

J Bone Miner Res. 2015 Dec;30(12):2262-72. doi: 10.1002/jbmr.2582. Epub 2015 Jul 29.

15.

Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome.

Bowen ME, Boyden ED, Holm IA, Campos-Xavier B, Bonafé L, Superti-Furga A, Ikegawa S, Cormier-Daire V, Bovée JV, Pansuriya TC, de Sousa SB, Savarirayan R, Andreucci E, Vikkula M, Garavelli L, Pottinger C, Ogino T, Sakai A, Regazzoni BM, Wuyts W, Sangiorgi L, Pedrini E, Zhu M, Kozakewich HP, Kasser JR, Seidman JG, Kurek KC, Warman ML.

PLoS Genet. 2011 Apr;7(4):e1002050. doi: 10.1371/journal.pgen.1002050. Epub 2011 Apr 14.

16.

Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum.

Li K, Leung AW, Guo Q, Yang W, Li JY.

J Neurosci. 2014 Jan 15;34(3):922-31. doi: 10.1523/JNEUROSCI.3476-13.2014.

17.

Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.

Usenko T, Chan G, Torlakovic E, Klingmüller U, Neel BG.

PLoS One. 2014 Oct 7;9(10):e109682. doi: 10.1371/journal.pone.0109682. eCollection 2014.

18.

Noonan syndrome, the Ras-MAPK signalling pathway and short stature.

Binder G.

Horm Res. 2009 Apr;71 Suppl 2:64-70. doi: 10.1159/000192439. Epub 2009 Apr 29. Review.

PMID:
19407499
19.

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.

Bauler TJ, Kamiya N, Lapinski PE, Langewisch E, Mishina Y, Wilkinson JE, Feng GS, King PD.

Dis Model Mech. 2011 Mar;4(2):228-39. doi: 10.1242/dmm.006130. Epub 2010 Nov 10.

20.

Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones.

Amano K, Densmore M, Fan Y, Lanske B.

Bone. 2016 Feb;83:256-266. doi: 10.1016/j.bone.2015.11.017. Epub 2015 Nov 24.

PMID:
26620087

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