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Items: 1 to 20 of 114


Estrogen reduces mechanical injury-related cell death and proteoglycan degradation in mature articular cartilage independent of the presence of the superficial zone tissue.

Imgenberg J, Rolauffs B, Grodzinsky AJ, Schünke M, Kurz B.

Osteoarthritis Cartilage. 2013 Nov;21(11):1738-45. doi: 10.1016/j.joca.2013.07.007. Epub 2013 Jul 14.


IL-10 reduces apoptosis and extracellular matrix degradation after injurious compression of mature articular cartilage.

Behrendt P, Preusse-Prange A, Klüter T, Haake M, Rolauffs B, Grodzinsky AJ, Lippross S, Kurz B.

Osteoarthritis Cartilage. 2016 Nov;24(11):1981-1988. doi: 10.1016/j.joca.2016.06.016. Epub 2016 Jun 24.


Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury.

DiMicco MA, Patwari P, Siparsky PN, Kumar S, Pratta MA, Lark MW, Kim YJ, Grodzinsky AJ.

Arthritis Rheum. 2004 Mar;50(3):840-8.


Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.

Patwari P, Cook MN, DiMicco MA, Blake SM, James IE, Kumar S, Cole AA, Lark MW, Grodzinsky AJ.

Arthritis Rheum. 2003 May;48(5):1292-301.


Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.

Sui Y, Lee JH, DiMicco MA, Vanderploeg EJ, Blake SM, Hung HH, Plaas AH, James IE, Song XY, Lark MW, Grodzinsky AJ.

Arthritis Rheum. 2009 Oct;60(10):2985-96. doi: 10.1002/art.24857.


A high-throughput model of post-traumatic osteoarthritis using engineered cartilage tissue analogs.

Mohanraj B, Meloni GR, Mauck RL, Dodge GR.

Osteoarthritis Cartilage. 2014 Sep;22(9):1282-90. doi: 10.1016/j.joca.2014.06.032. Epub 2014 Jul 4.


The effect of recombinant human fibroblast growth factor-18 on articular cartilage following single impact load.

Barr L, Getgood A, Guehring H, Rushton N, Henson FM.

J Orthop Res. 2014 Jul;32(7):923-7. doi: 10.1002/jor.22622. Epub 2014 Apr 9.


Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression.

Kurz B, Lemke A, Kehn M, Domm C, Patwari P, Frank EH, Grodzinsky AJ, Schünke M.

Arthritis Rheum. 2004 Jan;50(1):123-30.


Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold.

Li Y, Frank EH, Wang Y, Chubinskaya S, Huang HH, Grodzinsky AJ.

Osteoarthritis Cartilage. 2013 Dec;21(12):1933-41. doi: 10.1016/j.joca.2013.08.021. Epub 2013 Sep 3.


Inhibition of caspase-9 reduces chondrocyte apoptosis and proteoglycan loss following mechanical trauma.

Huser CA, Peacock M, Davies ME.

Osteoarthritis Cartilage. 2006 Oct;14(10):1002-10. Epub 2006 May 12.


Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.

Loening AM, James IE, Levenston ME, Badger AM, Frank EH, Kurz B, Nuttall ME, Hung HH, Blake SM, Grodzinsky AJ, Lark MW.

Arch Biochem Biophys. 2000 Sep 15;381(2):205-12.


Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage.

Patwari P, Cheng DM, Cole AA, Kuettner KE, Grodzinsky AJ.

Biomech Model Mechanobiol. 2007 Jan;6(1-2):83-9. Epub 2006 May 20.


Matrix and cell injury due to sub-impact loading of adult bovine articular cartilage explants: effects of strain rate and peak stress.

Quinn TM, Allen RG, Schalet BJ, Perumbuli P, Hunziker EB.

J Orthop Res. 2001 Mar;19(2):242-9.


The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants.

Piscoya JL, Fermor B, Kraus VB, Stabler TV, Guilak F.

Osteoarthritis Cartilage. 2005 Dec;13(12):1092-9. Epub 2005 Sep 13.


Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model.

Choi JH, Choi JH, Kim DY, Yoon JH, Youn HY, Yi JB, Rhee HI, Ryu KH, Jung K, Han CK, Kwak WJ, Cho YB.

Osteoarthritis Cartilage. 2002 Jun;10(6):471-8.

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