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Structure and function of CarD, an essential mycobacterial transcription factor.

Srivastava DB, Leon K, Osmundson J, Garner AL, Weiss LA, Westblade LF, Glickman MS, Landick R, Darst SA, Stallings CL, Campbell EA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12619-24. doi: 10.1073/pnas.1308270110. Epub 2013 Jul 15.


CarD stabilizes mycobacterial open complexes via a two-tiered kinetic mechanism.

Rammohan J, Ruiz Manzano A, Garner AL, Stallings CL, Galburt EA.

Nucleic Acids Res. 2015 Mar 31;43(6):3272-85. doi: 10.1093/nar/gkv078. Epub 2015 Feb 19.


Domains within RbpA Serve Specific Functional Roles That Regulate the Expression of Distinct Mycobacterial Gene Subsets.

Prusa J, Jensen D, Santiago-Collazo G, Pope SS, Garner AL, Miller JJ, Ruiz Manzano A, Galburt EA, Stallings CL.

J Bacteriol. 2018 Jun 11;200(13). pii: e00690-17. doi: 10.1128/JB.00690-17. Print 2018 Jul 1.


Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA.

Hubin EA, Fay A, Xu C, Bean JM, Saecker RM, Glickman MS, Darst SA, Campbell EA.

Elife. 2017 Jan 9;6. pii: e22520. doi: 10.7554/eLife.22520.


CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.

Bae B, Chen J, Davis E, Leon K, Darst SA, Campbell EA.

Elife. 2015 Sep 8;4. doi: 10.7554/eLife.08505.


Effects of Increasing the Affinity of CarD for RNA Polymerase on Mycobacterium tuberculosis Growth, rRNA Transcription, and Virulence.

Garner AL, Rammohan J, Huynh JP, Onder LM, Chen J, Bae B, Jensen D, Weiss LA, Manzano AR, Darst SA, Campbell EA, Nickels BE, Galburt EA, Stallings CL.

J Bacteriol. 2017 Jan 30;199(4). pii: e00698-16. doi: 10.1128/JB.00698-16. Print 2017 Feb 15.


Cooperative stabilization of Mycobacterium tuberculosis rrnAP3 promoter open complexes by RbpA and CarD.

Rammohan J, Ruiz Manzano A, Garner AL, Prusa J, Stallings CL, Galburt EA.

Nucleic Acids Res. 2016 Sep 6;44(15):7304-13. doi: 10.1093/nar/gkw577. Epub 2016 Jun 24.


Structure of the carboxy-terminal domain of Mycobacterium tuberculosis CarD protein: an essential rRNA transcriptional regulator.

Gangwar SP, Meena SR, Saxena AK.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):160-5. doi: 10.1107/S2053230X13034407. Epub 2014 Jan 21.


Structure of a bacterial RNA polymerase holoenzyme open promoter complex.

Bae B, Feklistov A, Lass-Napiorkowska A, Landick R, Darst SA.

Elife. 2015 Sep 8;4. doi: 10.7554/eLife.08504.


CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence.

Stallings CL, Stephanou NC, Chu L, Hochschild A, Nickels BE, Glickman MS.

Cell. 2009 Jul 10;138(1):146-59. doi: 10.1016/j.cell.2009.04.041.


Characteristics of the essential pathogenicity factor Rv1828, a MerR family transcription regulator from Mycobacterium tuberculosis.

Singh S, Sevalkar RR, Sarkar D, Karthikeyan S.

FEBS J. 2018 Dec;285(23):4424-4444. doi: 10.1111/febs.14676. Epub 2018 Oct 25.


CarD integrates three functional modules to promote efficient transcription, antibiotic tolerance, and pathogenesis in mycobacteria.

Garner AL, Weiss LA, Manzano AR, Galburt EA, Stallings CL.

Mol Microbiol. 2014 Aug;93(4):682-97. doi: 10.1111/mmi.12681. Epub 2014 Jul 16.


Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.

Hubin EA, Lilic M, Darst SA, Campbell EA.

Nat Commun. 2017 Jul 13;8:16072. doi: 10.1038/ncomms16072.


Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction.

Westblade LF, Campbell EA, Pukhrambam C, Padovan JC, Nickels BE, Lamour V, Darst SA.

Nucleic Acids Res. 2010 Dec;38(22):8357-69. doi: 10.1093/nar/gkq692. Epub 2010 Aug 11.


RbpA relaxes promoter selectivity of M. tuberculosis RNA polymerase.

Sudalaiyadum Perumal A, Vishwakarma RK, Hu Y, Morichaud Z, Brodolin K.

Nucleic Acids Res. 2018 Nov 2;46(19):10106-10118. doi: 10.1093/nar/gky714.


Structural basis of transcription activation.

Feng Y, Zhang Y, Ebright RH.

Science. 2016 Jun 10;352(6291):1330-3. doi: 10.1126/science.aaf4417.


Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD.

Davis E, Chen J, Leon K, Darst SA, Campbell EA.

Nucleic Acids Res. 2015 Jan;43(1):433-45. doi: 10.1093/nar/gku1231. Epub 2014 Dec 15.


Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture.

Kaur G, Dutta D, Thakur KG.

Proteins. 2014 May;82(5):879-84. doi: 10.1002/prot.24419. Epub 2013 Oct 18.


Novel mechanism of gene regulation: the protein Rv1222 of Mycobacterium tuberculosis inhibits transcription by anchoring the RNA polymerase onto DNA.

Rudra P, Prajapati RK, Banerjee R, Sengupta S, Mukhopadhyay J.

Nucleic Acids Res. 2015 Jul 13;43(12):5855-67. doi: 10.1093/nar/gkv516. Epub 2015 May 20.

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