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Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation.

Colbert KN, Hattendorf DA, Weiss TM, Burkhardt P, Fasshauer D, Weis WI.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12637-42. doi: 10.1073/pnas.1303753110. Epub 2013 Jul 15.


Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide.

Burkhardt P, Hattendorf DA, Weis WI, Fasshauer D.

EMBO J. 2008 Apr 9;27(7):923-33. doi: 10.1038/emboj.2008.37. Epub 2008 Mar 13.


Munc18a scaffolds SNARE assembly to promote membrane fusion.

Rodkey TL, Liu S, Barry M, McNew JA.

Mol Biol Cell. 2008 Dec;19(12):5422-34. doi: 10.1091/mbc.E08-05-0538. Epub 2008 Oct 1.


Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.

Rathore SS, Bend EG, Yu H, Hammarlund M, Jorgensen EM, Shen J.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22399-406. doi: 10.1073/pnas.1012997108. Epub 2010 Dec 7.


Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.

Khvotchev M, Dulubova I, Sun J, Dai H, Rizo J, Südhof TC.

J Neurosci. 2007 Nov 7;27(45):12147-55.


An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.

Parisotto D, Pfau M, Scheutzow A, Wild K, Mayer MP, Malsam J, Sinning I, Söllner TH.

J Biol Chem. 2014 Apr 4;289(14):9639-50. doi: 10.1074/jbc.M113.514273. Epub 2014 Feb 14.


Conformational switch of syntaxin-1 controls synaptic vesicle fusion.

Gerber SH, Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC.

Science. 2008 Sep 12;321(5895):1507-10. doi: 10.1126/science.1163174. Epub 2008 Aug 14.


Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.

Hu SH, Christie MP, Saez NJ, Latham CF, Jarrott R, Lua LH, Collins BM, Martin JL.

Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1040-5. doi: 10.1073/pnas.0914906108. Epub 2010 Dec 30.


Munc18b regulates core SNARE complex assembly and constitutive exocytosis by interacting with the N-peptide and the closed-conformation C-terminus of syntaxin 3.

Peng RW, Guetg C, Abellan E, Fussenegger M.

Biochem J. 2010 Nov 1;431(3):353-61. doi: 10.1042/BJ20100145.


Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex.

Dawidowski D, Cafiso DS.

Structure. 2016 Mar 1;24(3):392-400. doi: 10.1016/j.str.2016.01.005. Epub 2016 Feb 11.


Binding of Munc18-1 to synaptobrevin and to the SNARE four-helix bundle.

Xu Y, Su L, Rizo J.

Biochemistry. 2010 Mar 2;49(8):1568-76. doi: 10.1021/bi9021878.


Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide.

Christie MP, Whitten AE, King GJ, Hu SH, Jarrott RJ, Chen KE, Duff AP, Callow P, Collins BM, James DE, Martin JL.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9816-21. doi: 10.1073/pnas.1116975109. Epub 2012 Jun 5.


Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex.

Ma C, Li W, Xu Y, Rizo J.

Nat Struct Mol Biol. 2011 May;18(5):542-9. doi: 10.1038/nsmb.2047. Epub 2011 Apr 17.


SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion.

Shen J, Rathore SS, Khandan L, Rothman JE.

J Cell Biol. 2010 Jul 12;190(1):55-63. doi: 10.1083/jcb.201003148. Epub 2010 Jul 5.


Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming.

Deák F, Xu Y, Chang WP, Dulubova I, Khvotchev M, Liu X, Südhof TC, Rizo J.

J Cell Biol. 2009 Mar 9;184(5):751-64. doi: 10.1083/jcb.200812026. Epub 2009 Mar 2.


Munc18-1 binds directly to the neuronal SNARE complex.

Dulubova I, Khvotchev M, Liu S, Huryeva I, Südhof TC, Rizo J.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2697-702. Epub 2007 Feb 14.


Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin.

Zhang Y, Diao J, Colbert KN, Lai Y, Pfuetzner RA, Padolina MS, Vivona S, Ressl S, Cipriano DJ, Choi UB, Shah N, Weis WI, Brunger AT.

J Biol Chem. 2015 Apr 17;290(16):10518-34. doi: 10.1074/jbc.M114.630772. Epub 2015 Feb 25.


Munc18-1 as a key regulator of neurosecretion.

Han GA, Malintan NT, Collins BM, Meunier FA, Sugita S.

J Neurochem. 2010 Oct;115(1):1-10. doi: 10.1111/j.1471-4159.2010.06900.x. Review.


Molecular dissection of the Munc18c/syntaxin4 interaction: implications for regulation of membrane trafficking.

Latham CF, Lopez JA, Hu SH, Gee CL, Westbury E, Blair DH, Armishaw CJ, Alewood PF, Bryant NJ, James DE, Martin JL.

Traffic. 2006 Oct;7(10):1408-19. Epub 2006 Aug 10.


Dynamic conformational changes in munc18 prevent syntaxin binding.

Bar-On D, Nachliel E, Gutman M, Ashery U.

PLoS Comput Biol. 2011 Mar;7(3):e1001097. doi: 10.1371/journal.pcbi.1001097. Epub 2011 Mar 3.

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