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Items: 1 to 20 of 109

1.

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.

Amako Y, Igloi Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, Peers C, Harris M.

J Biol Chem. 2013 Aug 23;288(34):24753-63. doi: 10.1074/jbc.M113.491985. Epub 2013 Jul 15.

2.

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.

Macdonald A, Crowder K, Street A, McCormick C, Harris M.

J Gen Virol. 2004 Mar;85(Pt 3):721-9.

PMID:
14993658
3.

Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A.

Norris CA, He K, Springer MG, Hartnett KA, Horn JP, Aizenman E.

J Neurosci. 2012 Jun 27;32(26):8865-70. doi: 10.1523/JNEUROSCI.0937-12.2012.

4.

Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence.

Mankouri J, Dallas ML, Hughes ME, Griffin SD, Macdonald A, Peers C, Harris M.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15903-8. doi: 10.1073/pnas.0906798106. Epub 2009 Aug 26.

5.

Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.

Xiong W, Yang J, Wang M, Wang H, Rao Z, Zhong C, Xin X, Mo L, Yu S, Shen C, Zheng C.

J Virol. 2015 Jul;89(14):7385-400. doi: 10.1128/JVI.00567-15. Epub 2015 May 13.

6.

Critical role of Casein kinase 2 in hepatitis C NS5A-mediated inhibition of Kv2.1 K(+) channel function.

Clemens K, Yeh CY, Aizenman E.

Neurosci Lett. 2015 Nov 16;609:48-52. doi: 10.1016/j.neulet.2015.10.021. Epub 2015 Oct 17.

7.

Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation.

George A, Panda S, Kudmulwar D, Chhatbar SP, Nayak SC, Krishnan HH.

J Biol Chem. 2012 Feb 10;287(7):5042-58. doi: 10.1074/jbc.M111.308916. Epub 2011 Dec 19.

8.

Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction.

Igloi Z, Kazlauskas A, Saksela K, Macdonald A, Mankouri J, Harris M.

J Gen Virol. 2015 Aug;96(8):2133-44. doi: 10.1099/vir.0.000145. Epub 2015 Apr 13.

9.

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade.

Street A, Macdonald A, Crowder K, Harris M.

J Biol Chem. 2004 Mar 26;279(13):12232-41. Epub 2004 Jan 5.

10.

Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3.

Kokoszka ME, Kall SL, Khosla S, McGinnis JE, Lavie A, Kay BK.

J Biol Chem. 2018 Aug 31;293(35):13553-13565. doi: 10.1074/jbc.RA117.000262. Epub 2018 Jul 6.

11.
12.

Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1.

Qadri I, Iwahashi M, Capasso JM, Hopken MW, Flores S, Schaack J, Simon FR.

Biochem J. 2004 Mar 15;378(Pt 3):919-28. Erratum in: Biochem J. 2004 Jul 1;381(Pt 3):951.

13.

Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-α in infectious virus production.

Masaki T, Matsunaga S, Takahashi H, Nakashima K, Kimura Y, Ito M, Matsuda M, Murayama A, Kato T, Hirano H, Endo Y, Lemon SM, Wakita T, Sawasaki T, Suzuki T.

J Virol. 2014 Jul;88(13):7541-55. doi: 10.1128/JVI.03170-13. Epub 2014 Apr 23.

14.

Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.

Parvaiz F, Manzoor S, Iqbal J, Sarkar-Dutta M, Imran M, Waris G.

World J Gastroenterol. 2015 Nov 21;21(43):12361-9. doi: 10.3748/wjg.v21.i43.12361.

15.

The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.

Nanda SK, Herion D, Liang TJ.

Gastroenterology. 2006 Mar;130(3):794-809. Erratum in: Gastroenterology. 2006 Aug;131(2):687.

PMID:
16530520
16.

Hepatitis C virus nonstructural protein 5A inhibits thapsigargin-induced apoptosis.

Jiang X, Kanda T, Wu S, Nakamoto S, Wakita T, Shirasawa H, Yokosuka O.

PLoS One. 2014 Nov 19;9(11):e113499. doi: 10.1371/journal.pone.0113499. eCollection 2014.

17.

Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion.

Milward A, Mankouri J, Harris M.

J Gen Virol. 2010 Feb;91(Pt 2):373-81. doi: 10.1099/vir.0.015305-0. Epub 2009 Oct 21.

PMID:
19846673
18.

1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2.

Park KJ, Choi SH, Choi DH, Park JM, Yie SW, Lee SY, Hwang SB.

J Biol Chem. 2003 Aug 15;278(33):30711-8. Epub 2003 Jun 7.

19.

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.

Macdonald A, Mazaleyrat S, McCormick C, Street A, Burgoyne NJ, Jackson RM, Cazeaux V, Shelton H, Saksela K, Harris M.

J Gen Virol. 2005 Apr;86(Pt 4):1035-44.

PMID:
15784897
20.

Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation.

Wang WT, Tsai TY, Chao CH, Lai BY, Wu Lee YH.

J Virol. 2015 Nov;89(22):11584-602. doi: 10.1128/JVI.01513-15. Epub 2015 Sep 9.

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