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Items: 1 to 20 of 92


Integrase-defective lentiviral vectors as a delivery platform for targeted modification of adenosine deaminase locus.

Joglekar AV, Hollis RP, Kuftinec G, Senadheera S, Chan R, Kohn DB.

Mol Ther. 2013 Sep;21(9):1705-17. doi: 10.1038/mt.2013.106. Epub 2013 Jul 16.


Histone deacetylase inhibition rescues gene knockout levels achieved with integrase-defective lentiviral vectors encoding zinc-finger nucleases.

Pelascini LP, Maggio I, Liu J, Holkers M, Cathomen T, Gonçalves MA.

Hum Gene Ther Methods. 2013 Dec;24(6):399-411. doi: 10.1089/hgtb.2013.107. Epub 2013 Oct 29.


Codon swapping of zinc finger nucleases confers expression in primary cells and in vivo from a single lentiviral vector.

Abarrategui-Pontes C, Créneguy A, Thinard R, Fine EJ, Thepenier V, Fournier le RL, Cradick TJ, Bao G, Tesson L, Podevin G, Anegon I, Nguyen TH.

Curr Gene Ther. 2014;14(5):365-76.


Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery.

Lombardo A, Genovese P, Beausejour CM, Colleoni S, Lee YL, Kim KA, Ando D, Urnov FD, Galli C, Gregory PD, Holmes MC, Naldini L.

Nat Biotechnol. 2007 Nov;25(11):1298-306. Epub 2007 Oct 28.


Dissecting the mechanism of histone deacetylase inhibitors to enhance the activity of zinc finger nucleases delivered by integrase-defective lentiviral vectors.

Joglekar AV, Stein L, Ho M, Hoban MD, Hollis RP, Kohn DB.

Hum Gene Ther. 2014 Jul;25(7):599-608. doi: 10.1089/hum.2013.211. Epub 2014 Apr 2.


Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases.

Cai Y, Bak RO, Mikkelsen JG.

Elife. 2014 Apr 24;3:e01911. doi: 10.7554/eLife.01911.


Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination.

Coluccio A, Miselli F, Lombardo A, Marconi A, Malagoli Tagliazucchi G, Gonçalves MA, Pincelli C, Maruggi G, Del Rio M, Naldini L, Larcher F, Mavilio F, Recchia A.

Mol Ther. 2013 Sep;21(9):1695-704. doi: 10.1038/mt.2013.143. Epub 2013 Jun 13.


Integration-defective lentiviral vector mediates efficient gene editing through homology-directed repair in human embryonic stem cells.

Wang Y, Wang Y, Chang T, Huang H, Yee JK.

Nucleic Acids Res. 2017 Mar 17;45(5):e29. doi: 10.1093/nar/gkw1057.


A southern blot protocol to detect chimeric nuclease-mediated gene repair.

Rocca CJ, Abdul-Razak HH, Holmes MC, Gregory PD, Yáñez-Muñoz RJ.

Methods Mol Biol. 2014;1114:325-38. doi: 10.1007/978-1-62703-761-7_21.


Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells.

Pelascini LP, Janssen JM, Gonçalves MA.

Hum Gene Ther. 2013 Jan;24(1):78-96. doi: 10.1089/hum.2012.069. Epub 2012 Dec 11.


Zinc finger nuclease-expressing baculoviral vectors mediate targeted genome integration of reprogramming factor genes to facilitate the generation of human induced pluripotent stem cells.

Phang RZ, Tay FC, Goh SL, Lau CH, Zhu H, Tan WK, Liang Q, Chen C, Du S, Li Z, Tay JC, Wu C, Zeng J, Fan W, Toh HC, Wang S.

Stem Cells Transl Med. 2013 Dec;2(12):935-45. doi: 10.5966/sctm.2013-0043. Epub 2013 Oct 28.


Integrase-defective lentiviral vectors--a stage for nonviral integration machineries.

Staunstrup NH, Mikkelsen JG.

Curr Gene Ther. 2011 Oct;11(5):350-62. Review.


Proviral HIV-genome-wide and pol-gene specific zinc finger nucleases: usability for targeted HIV gene therapy.

Wayengera M.

Theor Biol Med Model. 2011 Jul 22;8:26. doi: 10.1186/1742-4682-8-26.


Lentiviral vectors encoding zinc-finger nucleases specific for the model target locus HPRT1.

Pelascini LP, Gonçalves MA.

Methods Mol Biol. 2014;1114:181-99. doi: 10.1007/978-1-62703-761-7_12.


Genome editing with CompoZr custom zinc finger nucleases (ZFNs).

Hansen K, Coussens MJ, Sago J, Subramanian S, Gjoka M, Briner D.

J Vis Exp. 2012 Jun 14;(64):e3304. doi: 10.3791/3304.


Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.

Händel EM, Gellhaus K, Khan K, Bednarski C, Cornu TI, Müller-Lerch F, Kotin RM, Heilbronn R, Cathomen T.

Hum Gene Ther. 2012 Mar;23(3):321-9. doi: 10.1089/hum.2011.140. Epub 2011 Dec 14.


Targeted genome modifications using integrase-deficient lentiviral vectors.

Cornu TI, Cathomen T.

Mol Ther. 2007 Dec;15(12):2107-13. Epub 2007 Nov 13.


Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors.

Cai Y, Laustsen A, Zhou Y, Sun C, Anderson MV, Li S, Uldbjerg N, Luo Y, Jakobsen MR, Mikkelsen JG.

Elife. 2016 Jun 9;5. pii: e12213. doi: 10.7554/eLife.12213.


Integration-deficient lentiviral vectors: a slow coming of age.

Wanisch K, Yáñez-Muñoz RJ.

Mol Ther. 2009 Aug;17(8):1316-32. doi: 10.1038/mt.2009.122. Epub 2009 Jun 2. Review.


Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk.

Chick HE, Nowrouzi A, Fronza R, McDonald RA, Kane NM, Alba R, Delles C, Sessa WC, Schmidt M, Thrasher AJ, Baker AH.

Hum Gene Ther. 2012 Dec;23(12):1247-57. doi: 10.1089/hum.2012.042. Epub 2012 Oct 26.

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