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Items: 1 to 20 of 263

1.

Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice.

Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC.

Ann Rheum Dis. 2014 Sep;73(9):1719-27. doi: 10.1136/annrheumdis-2013-203231. Epub 2013 Jul 12.

PMID:
23852692
2.

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis.

Zhang Y, Vasheghani F, Li YH, Blati M, Simeone K, Fahmi H, Lussier B, Roughley P, Lagares D, Pelletier JP, Martel-Pelletier J, Kapoor M.

Ann Rheum Dis. 2015 Jul;74(7):1432-40. doi: 10.1136/annrheumdis-2013-204599. Epub 2014 Mar 20.

PMID:
24651621
3.

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis.

Caramés B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M.

Ann Rheum Dis. 2012 Apr;71(4):575-81. doi: 10.1136/annrheumdis-2011-200557. Epub 2011 Nov 14.

4.

Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice.

Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM.

Osteoarthritis Cartilage. 2014 Sep;22(9):1301-9. doi: 10.1016/j.joca.2014.06.033. Epub 2014 Jul 4.

5.

Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.

Zainal Z, Longman AJ, Hurst S, Duggan K, Caterson B, Hughes CE, Harwood JL.

Osteoarthritis Cartilage. 2009 Jul;17(7):896-905. doi: 10.1016/j.joca.2008.12.009. Epub 2009 Jan 13.

6.

Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D.

Arthritis Rheum. 2013 Dec;65(12):3107-19. doi: 10.1002/art.38122.

7.

Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis.

Latourte A, Cherifi C, Maillet J, Ea HK, Bouaziz W, Funck-Brentano T, Cohen-Solal M, Hay E, Richette P.

Ann Rheum Dis. 2017 Apr;76(4):748-755. doi: 10.1136/annrheumdis-2016-209757. Epub 2016 Oct 27.

PMID:
27789465
8.

Alterations of high-mannose type N-glycosylation in human and mouse osteoarthritis cartilage.

Urita A, Matsuhashi T, Onodera T, Nakagawa H, Hato M, Amano M, Seito N, Minami A, Nishimura S, Iwasaki N.

Arthritis Rheum. 2011 Nov;63(11):3428-38. doi: 10.1002/art.30584.

10.

Insulin decreases autophagy and leads to cartilage degradation.

Ribeiro M, López de Figueroa P, Blanco FJ, Mendes AF, Caramés B.

Osteoarthritis Cartilage. 2016 Apr;24(4):731-9. doi: 10.1016/j.joca.2015.10.017. Epub 2015 Nov 5.

11.

Depletion of gangliosides enhances cartilage degradation in mice.

Sasazawa F, Onodera T, Yamashita T, Seito N, Tsukuda Y, Fujitani N, Shinohara Y, Iwasaki N.

Osteoarthritis Cartilage. 2014 Feb;22(2):313-22. doi: 10.1016/j.joca.2013.11.015. Epub 2013 Dec 12.

12.

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.

Weng T, Yi L, Huang J, Luo F, Wen X, Du X, Chen Q, Deng C, Chen D, Chen L.

Arthritis Rheum. 2012 Dec;64(12):3982-92. doi: 10.1002/art.34645.

13.

Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo.

Zhu S, Lu P, Liu H, Chen P, Wu Y, Wang Y, Sun H, Zhang X, Xia Q, Heng BC, Zhou Y, Ouyang HW.

Ann Rheum Dis. 2015 Jan;74(1):285-93. doi: 10.1136/annrheumdis-2013-203901. Epub 2013 Nov 20.

14.

Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13.

Attur M, Yang Q, Shimada K, Tachida Y, Nagase H, Mignatti P, Statman L, Palmer G, Kirsch T, Beier F, Abramson SB.

FASEB J. 2015 Oct;29(10):4107-21. doi: 10.1096/fj.15-272427. Epub 2015 Jun 19.

15.

Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes.

Jeong JH, Moon SJ, Jhun JY, Yang EJ, Cho ML, Min JK.

PLoS One. 2015 Jun 17;10(6):e0130882. doi: 10.1371/journal.pone.0130882. eCollection 2015.

16.

Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis.

Weng T, Xie Y, Yi L, Huang J, Luo F, Du X, Chen L, Liu C, Chen D, Chen L.

Osteoarthritis Cartilage. 2014 Aug;22(8):1197-205. doi: 10.1016/j.joca.2014.06.031. Epub 2014 Jul 4.

17.

Lithium protects against cartilage degradation in osteoarthritis.

Minashima T, Zhang Y, Lee Y, Kirsch T.

Arthritis Rheumatol. 2014 May;66(5):1228-36. doi: 10.1002/art.38373.

18.

Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis.

Chu X, You H, Yuan X, Zhao W, Li W, Guo X.

Int J Mol Med. 2013 May;31(5):1222-8. doi: 10.3892/ijmm.2013.1318. Epub 2013 Mar 26.

PMID:
23546441
19.

mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.

Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y, Bai X.

Oncogene. 2014 Sep 11;33(37):4548-57. doi: 10.1038/onc.2013.402. Epub 2013 Oct 7.

PMID:
24096482
20.

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.

Otsuki S, Hanson SR, Miyaki S, Grogan SP, Kinoshita M, Asahara H, Wong CH, Lotz MK.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10202-7. doi: 10.1073/pnas.0913897107. Epub 2010 May 17.

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