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Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.

Namekata K, Kimura A, Kawamura K, Guo X, Harada C, Tanaka K, Harada T.

Cell Death Differ. 2013 Sep;20(9):1250-6. doi: 10.1038/cdd.2013.91.


Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity.

Bai N, Hayashi H, Aida T, Namekata K, Harada T, Mishina M, Tanaka K.

Mol Brain. 2013 May 4;6:22. doi: 10.1186/1756-6606-6-22.


Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma.

Kimura A, Guo X, Noro T, Harada C, Tanaka K, Namekata K, Harada T.

Neurosci Lett. 2015 Feb 19;588:108-13. doi: 10.1016/j.neulet.2014.12.054.


ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma.

Harada C, Namekata K, Guo X, Yoshida H, Mitamura Y, Matsumoto Y, Tanaka K, Ichijo H, Harada T.

Cell Death Differ. 2010 Nov;17(11):1751-9. doi: 10.1038/cdd.2010.62.


Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice.

Namekata K, Harada C, Guo X, Kikushima K, Kimura A, Fuse N, Mitamura Y, Kohyama K, Matsumoto Y, Tanaka K, Harada T.

Neurosci Lett. 2009 Nov 13;465(2):160-4. doi: 10.1016/j.neulet.2009.09.029.


Dock3 overexpression and p38 MAPK inhibition synergistically stimulate neuroprotection and axon regeneration after optic nerve injury.

Semba K, Namekata K, Kimura A, Harada C, Katome T, Yoshida H, Mitamura Y, Harada T.

Neurosci Lett. 2014 Oct 3;581:89-93. doi: 10.1016/j.neulet.2014.08.034.


Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma.

Semba K, Namekata K, Kimura A, Harada C, Mitamura Y, Harada T.

Cell Death Dis. 2014 Jul 17;5:e1341. doi: 10.1038/cddis.2014.306.


Dock3 protects myelin in the cuprizone model for demyelination.

Namekata K, Kimura A, Harada C, Yoshida H, Matsumoto Y, Harada T.

Cell Death Dis. 2014 Aug 28;5:e1395. doi: 10.1038/cddis.2014.357.


Dock3-NMDA receptor interaction as a target for glaucoma therapy.

Kimura A, Namekata K, Guo X, Harada C, Harada T.

Histol Histopathol. 2016 Sep 9:11820. [Epub ahead of print] Review.


NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina.

Bai N, Aida T, Yanagisawa M, Katou S, Sakimura K, Mishina M, Tanaka K.

Mol Brain. 2013 Jul 31;6:34. doi: 10.1186/1756-6606-6-34.


Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma.

Lee D, Shim MS, Kim KY, Noh YH, Kim H, Kim SY, Weinreb RN, Ju WK.

Invest Ophthalmol Vis Sci. 2014 Feb 18;55(2):993-1005. doi: 10.1167/iovs.13-12564.


Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor.

Furuya T, Pan Z, Kashiwagi K.

Curr Eye Res. 2012 Mar;37(3):170-8. doi: 10.3109/02713683.2011.645105.


Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST?

Delyfer MN, Simonutti M, Neveux N, Léveillard T, Sahel JA.

Mol Vis. 2005 Sep 1;11:677-87.


Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma.

Yanagisawa M, Aida T, Takeda T, Namekata K, Harada T, Shinagawa R, Tanaka K.

Cell Death Dis. 2015 Mar 19;6:e1693. doi: 10.1038/cddis.2015.45.


Alpha2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity.

Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA.

Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4515-22. doi: 10.1167/iovs.08-2078.


The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma.

Harada T, Harada C, Nakamura K, Quah HM, Okumura A, Namekata K, Saeki T, Aihara M, Yoshida H, Mitani A, Tanaka K.

J Clin Invest. 2007 Jul;117(7):1763-70.


Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation.

Nakamura-Yanagidaira T, Takahashi Y, Sano K, Murata T, Hayashi T.

Mol Vis. 2011;17:2157-70.


Invulnerability of retinal ganglion cells to NMDA excitotoxicity.

Ullian EM, Barkis WB, Chen S, Diamond JS, Barres BA.

Mol Cell Neurosci. 2004 Aug;26(4):544-57.


Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling.

Shimazawa M, Inokuchi Y, Okuno T, Nakajima Y, Sakaguchi G, Kato A, Oku H, Sugiyama T, Kudo T, Ikeda T, Takeda M, Hara H.

J Neurochem. 2008 Oct;107(1):279-90. doi: 10.1111/j.1471-4159.2008.05606.x.


A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.

Hayashi H, Eguchi Y, Fukuchi-Nakaishi Y, Takeya M, Nakagata N, Tanaka K, Vance JE, Tanihara H.

J Biol Chem. 2012 Jul 20;287(30):25395-406. doi: 10.1074/jbc.M112.370130.

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