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Items: 1 to 20 of 114

1.

Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3.

Dou H, Buetow L, Sibbet GJ, Cameron K, Huang DT.

Nat Struct Mol Biol. 2013 Aug;20(8):982-6. doi: 10.1038/nsmb.2621. Epub 2013 Jul 14.

2.

BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.

Dou H, Buetow L, Sibbet GJ, Cameron K, Huang DT.

Nat Struct Mol Biol. 2012 Sep;19(9):876-83. doi: 10.1038/nsmb.2379. Epub 2012 Aug 14.

3.

Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin.

Buetow L, Gabrielsen M, Anthony NG, Dou H, Patel A, Aitkenhead H, Sibbet GJ, Smith BO, Huang DT.

Mol Cell. 2015 Apr 16;58(2):297-310. doi: 10.1016/j.molcel.2015.02.017. Epub 2015 Mar 19.

4.

Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.

Pruneda JN, Littlefield PJ, Soss SE, Nordquist KA, Chazin WJ, Brzovic PS, Klevit RE.

Mol Cell. 2012 Sep 28;47(6):933-42. doi: 10.1016/j.molcel.2012.07.001. Epub 2012 Aug 9.

5.

E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity.

Huang A, de Jong RN, Wienk H, Winkler GS, Timmers HT, Boelens R.

J Mol Biol. 2009 Jan 16;385(2):507-19. doi: 10.1016/j.jmb.2008.10.044. Epub 2008 Nov 1.

PMID:
18996392
6.

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

Wenzel DM, Lissounov A, Brzovic PS, Klevit RE.

Nature. 2011 Jun 2;474(7349):105-8. doi: 10.1038/nature09966. Epub 2011 May 1.

7.

Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.

Zhen Y, Qin G, Luo C, Jiang H, Yu K, Chen G.

PLoS One. 2014 Jul 8;9(7):e101663. doi: 10.1371/journal.pone.0101663. eCollection 2014.

8.

Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase.

Nakatani Y, Kleffmann T, Linke K, Condon SM, Hinds MG, Day CL.

Biochem J. 2013 Mar 15;450(3):629-38. doi: 10.1042/BJ20121702.

PMID:
23259674
9.

Structural insights into the conformation and oligomerization of E2~ubiquitin conjugates.

Page RC, Pruneda JN, Amick J, Klevit RE, Misra S.

Biochemistry. 2012 May 22;51(20):4175-87. doi: 10.1021/bi300058m. Epub 2012 May 14.

10.

Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b.

Peschard P, Kozlov G, Lin T, Mirza IA, Berghuis AM, Lipkowitz S, Park M, Gehring K.

Mol Cell. 2007 Aug 3;27(3):474-85.

11.

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

Brown NG, VanderLinden R, Watson ER, Qiao R, Grace CR, Yamaguchi M, Weissmann F, Frye JJ, Dube P, Ei Cho S, Actis ML, Rodrigues P, Fujii N, Peters JM, Stark H, Schulman BA.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5272-9. doi: 10.1073/pnas.1504161112. Epub 2015 Mar 30.

12.

Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.

Kamadurai HB, Souphron J, Scott DC, Duda DM, Miller DJ, Stringer D, Piper RC, Schulman BA.

Mol Cell. 2009 Dec 25;36(6):1095-102. doi: 10.1016/j.molcel.2009.11.010.

13.

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.

Zheng N, Wang P, Jeffrey PD, Pavletich NP.

Cell. 2000 Aug 18;102(4):533-9.

14.

Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases.

Cohen I, Wiener R, Reiss Y, Ravid T.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E625-32. doi: 10.1073/pnas.1415621112. Epub 2015 Feb 2.

15.

Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34.

Sadowski M, Suryadinata R, Lai X, Heierhorst J, Sarcevic B.

Mol Cell Biol. 2010 May;30(10):2316-29. doi: 10.1128/MCB.01094-09. Epub 2010 Mar 1.

16.

Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

Kim HT, Kim KP, Lledias F, Kisselev AF, Scaglione KM, Skowyra D, Gygi SP, Goldberg AL.

J Biol Chem. 2007 Jun 15;282(24):17375-86. Epub 2007 Apr 10.

17.

Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights.

Zhou ZR, Gao HC, Zhou CJ, Chang YG, Hong J, Song AX, Lin DH, Hu HY.

Protein Sci. 2008 Oct;17(10):1805-14. doi: 10.1110/ps.036384.108. Epub 2008 Jul 2.

18.

The mechanism of OTUB1-mediated inhibition of ubiquitination.

Wiener R, Zhang X, Wang T, Wolberger C.

Nature. 2012 Feb 22;483(7391):618-22. doi: 10.1038/nature10911.

19.

E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.

Soss SE, Yue Y, Dhe-Paganon S, Chazin WJ.

J Biol Chem. 2011 Jun 17;286(24):21277-86. doi: 10.1074/jbc.M111.224006. Epub 2011 Apr 25.

20.

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.

Chong RA, Wu K, Spratt DE, Yang Y, Lee C, Nayak J, Xu M, Elkholi R, Tappin I, Li J, Hurwitz J, Brown BD, Chipuk JE, Chen ZJ, Sanchez R, Shaw GS, Huang L, Pan ZQ.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8434-9. doi: 10.1073/pnas.1407849111. Epub 2014 May 27.

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