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Items: 1 to 20 of 82

1.

Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment.

Su SC, Rudenko A, Cho S, Tsai LH.

Neurobiol Learn Mem. 2013 Oct;105:54-62. doi: 10.1016/j.nlm.2013.06.016. Epub 2013 Jul 11.

2.

Cdk5/p35 functions as a crucial regulator of spatial learning and memory.

Mishiba T, Tanaka M, Mita N, He X, Sasamoto K, Itohara S, Ohshima T.

Mol Brain. 2014 Nov 18;7:82. doi: 10.1186/s13041-014-0082-x.

3.

Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain.

Mita N, He X, Sasamoto K, Mishiba T, Ohshima T.

Cereb Cortex. 2016 Mar;26(3):967-976. doi: 10.1093/cercor/bhu264. Epub 2014 Nov 17.

PMID:
25404468
4.

Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.

Takahashi S, Ohshima T, Hirasawa M, Pareek TK, Bugge TH, Morozov A, Fujieda K, Brady RO, Kulkarni AB.

Am J Pathol. 2010 Jan;176(1):320-9. doi: 10.2353/ajpath.2010.081158. Epub 2009 Nov 30.

5.

Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality.

Utreras E, Hamada R, Prochazkova M, Terse A, Takahashi S, Ohshima T, Kulkarni AB.

J Neuroinflammation. 2014 Feb 5;11:28. doi: 10.1186/1742-2094-11-28.

6.

Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1).

Giusti-Rodríguez P, Gao J, Gräff J, Rei D, Soda T, Tsai LH.

J Neurosci. 2011 Nov 2;31(44):15751-6. doi: 10.1523/JNEUROSCI.3588-11.2011.

7.

Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.

Guan JS, Su SC, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr SA, Tsai LH.

PLoS One. 2011;6(9):e25735. doi: 10.1371/journal.pone.0025735. Epub 2011 Sep 30.

8.

Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.

Hawasli AH, Koovakkattu D, Hayashi K, Anderson AE, Powell CM, Sinton CM, Bibb JA, Cooper DC.

PLoS One. 2009 Jun 4;4(6):e5808. doi: 10.1371/journal.pone.0005808.

9.

Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment.

Rudenko A, Seo J, Hu J, Su SC, de Anda FC, Durak O, Ericsson M, Carlén M, Tsai LH.

J Neurosci. 2015 Feb 11;35(6):2372-83. doi: 10.1523/JNEUROSCI.0969-14.2015.

10.

Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors.

Zhong P, Liu X, Zhang Z, Hu Y, Liu SJ, Lezama-Ruiz M, Joksimovic M, Liu QS.

J Neurosci. 2014 Apr 30;34(18):6352-66. doi: 10.1523/JNEUROSCI.3673-13.2014.

11.

Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.

Ohshima T, Hirasawa M, Tabata H, Mutoh T, Adachi T, Suzuki H, Saruta K, Iwasato T, Itohara S, Hashimoto M, Nakajima K, Ogawa M, Kulkarni AB, Mikoshiba K.

Development. 2007 Jun;134(12):2273-82. Epub 2007 May 16.

12.

Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability.

Benavides DR, Quinn JJ, Zhong P, Hawasli AH, DiLeone RJ, Kansy JW, Olausson P, Yan Z, Taylor JR, Bibb JA.

J Neurosci. 2007 Nov 21;27(47):12967-76.

13.

Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice.

Ohshima T, Ogura H, Tomizawa K, Hayashi K, Suzuki H, Saito T, Kamei H, Nishi A, Bibb JA, Hisanaga S, Matsui H, Mikoshiba K.

J Neurochem. 2005 Aug;94(4):917-25. Epub 2005 Jun 30.

14.

Ablation of Ca(V)2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments.

Mallmann RT, Elgueta C, Sleman F, Castonguay J, Wilmes T, van den Maagdenberg A, Klugbauer N.

PLoS One. 2013 Oct 31;8(10):e78598. doi: 10.1371/journal.pone.0078598. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/d8de7f3c-6be2-44b6-b835-3cfd1518d7f5.

15.

Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice.

Gorski JA, Balogh SA, Wehner JM, Jones KR.

Neuroscience. 2003;121(2):341-54.

PMID:
14521993
16.

Memory enhancement by targeting Cdk5 regulation of NR2B.

Plattner F, Hernández A, Kistler TM, Pozo K, Zhong P, Yuen EY, Tan C, Hawasli AH, Cooke SF, Nishi A, Guo A, Wiederhold T, Yan Z, Bibb JA.

Neuron. 2014 Mar 5;81(5):1070-83. doi: 10.1016/j.neuron.2014.01.022.

17.

The role of Cdk5 in cognition and neuropsychiatric and neurological pathology.

Barnett DG, Bibb JA.

Brain Res Bull. 2011 Apr 25;85(1-2):9-13. doi: 10.1016/j.brainresbull.2010.11.016. Epub 2010 Dec 7. Review.

18.

Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

Chen HR, Lin GT, Huang CK, Fann MJ.

Exp Neurol. 2014 Nov;261:10-21. doi: 10.1016/j.expneurol.2014.06.024. Epub 2014 Jul 3.

19.

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology.

Polydoro M, Acker CM, Duff K, Castillo PE, Davies P.

J Neurosci. 2009 Aug 26;29(34):10741-9. doi: 10.1523/JNEUROSCI.1065-09.2009.

20.

Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation.

Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P.

Dev Cell. 2011 Oct 18;21(4):655-68. doi: 10.1016/j.devcel.2011.08.009. Epub 2011 Sep 22.

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