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Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer.

Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A, Drechsel N, Charneco C, Davis S, Bellora N, Gallardo F, López-Arribillaga E, Asensio-Juan E, Rodilla V, González J, Iglesias M, Shih V, Mar Albà M, Di Croce L, Hoffmann A, Miyamoto S, Villà-Freixa J, López-Bigas N, Keyes WM, Domínguez M, Bigas A, Espinosa L.

Cancer Cell. 2013 Aug 12;24(2):151-66. doi: 10.1016/j.ccr.2013.06.003. Epub 2013 Jul 11.


Novel functions of chromatin-bound IκBα in oncogenic transformation.

Espinosa L, Bigas A, Mulero MC.

Br J Cancer. 2014 Oct 28;111(9):1688-92. doi: 10.1038/bjc.2014.84. Epub 2014 Sep 18. Review.


Emerging from NF-κB's shadow, SUMOylated IκBα represses transcription.

Perkins ND.

Cancer Cell. 2013 Aug 12;24(2):139-40. doi: 10.1016/j.ccr.2013.07.011.


Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression.

Aguilera C, Hoya-Arias R, Haegeman G, Espinosa L, Bigas A.

Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16537-42. Epub 2004 Nov 9.


IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis.

Cataisson C, Salcedo R, Hakim S, Moffitt BA, Wright L, Yi M, Stephens R, Dai RM, Lyakh L, Schenten D, Yuspa HS, Trinchieri G.

J Exp Med. 2012 Aug 27;209(9):1689-702. doi: 10.1084/jem.20101355. Epub 2012 Aug 20.


Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.

Thomas RK, Sos ML, Zander T, Mani O, Popov A, Berenbrinker D, Smola-Hess S, Schultze JL, Wolf J.

Clin Cancer Res. 2005 Nov 15;11(22):8186-94.


Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A.

Neuhöfer P, Liang S, Einwächter H, Schwerdtfeger C, Wartmann T, Treiber M, Zhang H, Schulz HU, Dlubatz K, Lesina M, Diakopoulos KN, Wörmann S, Halangk W, Witt H, Schmid RM, Algül H.

Gastroenterology. 2013 Jan;144(1):192-201. doi: 10.1053/j.gastro.2012.09.058. Epub 2012 Oct 3.


MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated activation of genes downstream of NF-κB.

Wang X, Zhu K, Li S, Liao Y, Du R, Zhang X, Shu HB, Guo AY, Li L, Wu M.

J Cell Sci. 2012 Sep 1;125(Pt 17):4058-66. doi: 10.1242/jcs.103531. Epub 2012 May 23.


EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.

Jiang R, Li Y, Xu Y, Zhou Y, Pang Y, Shen L, Zhao Y, Zhang J, Zhou J, Wang X, Liu Q.

Arch Toxicol. 2013 Jun;87(6):991-1000. doi: 10.1007/s00204-012-0933-0. Epub 2012 Oct 16.


Mathematical model of NF-kappaB regulatory module.

Lipniacki T, Paszek P, Brasier AR, Luxon B, Kimmel M.

J Theor Biol. 2004 May 21;228(2):195-215.


Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma.

Loercher A, Lee TL, Ricker JL, Howard A, Geoghegen J, Chen Z, Sunwoo JB, Sitcheran R, Chuang EY, Mitchell JB, Baldwin AS Jr, Van Waes C.

Cancer Res. 2004 Sep 15;64(18):6511-23. Erratum in: Cancer Res. 2004 Nov 1;64(21):8130-2.


Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.

Tsuchiya Y, Asano T, Nakayama K, Kato T Jr, Karin M, Kamata H.

Mol Cell. 2010 Aug 27;39(4):570-82. doi: 10.1016/j.molcel.2010.07.030.


Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes.

Amici C, Rossi A, Costanzo A, Ciafrè S, Marinari B, Balsamo M, Levrero M, Santoro MG.

J Biol Chem. 2006 Mar 17;281(11):7110-7. Epub 2006 Jan 3.


Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha.

Horion J, Gloire G, El Mjiyad N, Quivy V, Vermeulen L, Vanden Berghe W, Haegeman G, Van Lint C, Piette J, Habraken Y.

J Biol Chem. 2007 May 25;282(21):15383-93. Epub 2007 Apr 4.


Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation.

Ludwig L, Kessler H, Wagner M, Hoang-Vu C, Dralle H, Adler G, Böhm BO, Schmid RM.

Cancer Res. 2001 Jun 1;61(11):4526-35.


Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.

Weil R, Sirma H, Giannini C, Kremsdorf D, Bessia C, Dargemont C, Bréchot C, Israël A.

Mol Cell Biol. 1999 Sep;19(9):6345-54.


Cancer: More than skin deep.

Bolotin D, Fuchs E.

Nature. 2003 Feb 6;421(6923):594-5. No abstract available.


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