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Items: 1 to 20 of 147

1.

Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine.

Xue L, Hou S, Tong M, Fang L, Chen X, Jin Z, Tai HH, Zheng F, Zhan CG.

Biochem J. 2013 Aug 1;453(3):447-54. doi: 10.1042/BJ20130549.

2.

Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine.

Xue L, Hou S, Yang W, Fang L, Zheng F, Zhan CG.

Chem Biol Interact. 2013 Mar 25;203(1):57-62. doi: 10.1016/j.cbi.2012.08.003. Epub 2012 Aug 11.

3.

Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.

Yang W, Xue L, Fang L, Chen X, Zhan CG.

Chem Biol Interact. 2010 Sep 6;187(1-3):148-52. doi: 10.1016/j.cbi.2010.01.004. Epub 2010 Jan 11.

4.

Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine.

Zhan M, Hou S, Zhan CG, Zheng F.

Biochem J. 2014 Jan 1;457(1):197-206. doi: 10.1042/BJ20131100.

5.

Substrate selectivity of high-activity mutants of human butyrylcholinesterase.

Hou S, Xue L, Yang W, Fang L, Zheng F, Zhan CG.

Org Biomol Chem. 2013 Nov 21;11(43):7477-85. doi: 10.1039/c3ob41713a.

6.

Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.

Xue L, Ko MC, Tong M, Yang W, Hou S, Fang L, Liu J, Zheng F, Woods JH, Tai HH, Zhan CG.

Mol Pharmacol. 2011 Feb;79(2):290-7. doi: 10.1124/mol.110.068494. Epub 2010 Oct 22.

7.

Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats.

Chen X, Zheng X, Zhou Z, Zhan CG, Zheng F.

Chem Biol Interact. 2016 Nov 25;259(Pt B):104-109. doi: 10.1016/j.cbi.2016.05.003. Epub 2016 May 3.

8.

Computational redesign of human butyrylcholinesterase for anticocaine medication.

Pan Y, Gao D, Yang W, Cho H, Yang G, Tai HH, Zhan CG.

Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16656-61. Epub 2005 Nov 7.

9.

Rational design of an enzyme mutant for anti-cocaine therapeutics.

Zheng F, Zhan CG.

J Comput Aided Mol Des. 2008 Sep;22(9):661-71. Epub 2007 Nov 8. Review.

11.

Amino-acid mutations to extend the biological half-life of a therapeutically valuable mutant of human butyrylcholinesterase.

Fang L, Hou S, Xue L, Zheng F, Zhan CG.

Chem Biol Interact. 2014 May 5;214:18-25. doi: 10.1016/j.cbi.2014.02.007. Epub 2014 Feb 25.

12.

Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene.

Hou S, Zhan M, Zheng X, Zhan CG, Zheng F.

Biochem J. 2014 Jun 15;460(3):447-57. doi: 10.1042/BJ20140360.

13.

Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants.

Hamza A, Cho H, Tai HH, Zhan CG.

J Phys Chem B. 2005 Mar 17;109(10):4776-82.

14.

Most efficient cocaine hydrolase designed by virtual screening of transition states.

Zheng F, Yang W, Ko MC, Liu J, Cho H, Gao D, Tong M, Tai HH, Woods JH, Zhan CG.

J Am Chem Soc. 2008 Sep 10;130(36):12148-55. doi: 10.1021/ja803646t. Epub 2008 Aug 19.

15.

An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient.

Xie W, Altamirano CV, Bartels CF, Speirs RJ, Cashman JR, Lockridge O.

Mol Pharmacol. 1999 Jan;55(1):83-91.

16.

Re-engineering butyrylcholinesterase as a cocaine hydrolase.

Sun H, Pang YP, Lockridge O, Brimijoin S.

Mol Pharmacol. 2002 Aug;62(2):220-4.

17.

A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.

Brimijoin S, Gao Y, Anker JJ, Gliddon LA, Lafleur D, Shah R, Zhao Q, Singh M, Carroll ME.

Neuropsychopharmacology. 2008 Oct;33(11):2715-25. doi: 10.1038/sj.npp.1301666. Epub 2008 Jan 16.

18.

Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase.

Carmona GN, Schindler CW, Shoaib M, Jufer R, Cone EJ, Goldberg SR, Greig NH, Yu QS, Gorelick DA.

Exp Clin Psychopharmacol. 1998 Aug;6(3):274-9.

PMID:
9725111
19.

Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.

Geng L, Gao Y, Chen X, Hou S, Zhan CG, Radic Z, Parks RJ, Russell SJ, Pham L, Brimijoin S.

PLoS One. 2013 Jun 28;8(6):e67446. doi: 10.1371/journal.pone.0067446. Print 2013.

20.

Free energy perturbation simulation on transition states and high-activity mutants of human butyrylcholinesterase for (-)-cocaine hydrolysis.

Yang W, Pan Y, Fang L, Gao D, Zheng F, Zhan CG.

J Phys Chem B. 2010 Aug 26;114(33):10889-96. doi: 10.1021/jp104989b.

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