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Items: 1 to 20 of 174

1.

RUNX1, but not its familial platelet disorder mutants, synergistically activates PF4 gene expression in combination with ETS family proteins.

Okada Y, Watanabe M, Nakai T, Kamikawa Y, Shimizu M, Fukuhara Y, Yonekura M, Matsuura E, Hoshika Y, Nagai R, Aird WC, Doi T.

J Thromb Haemost. 2013 Sep;11(9):1742-50. doi: 10.1111/jth.12355.

2.

Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site.

Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A, Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T, Kitajima K, Nakano T, Aird WC, Doi T.

PLoS One. 2011;6(9):e24837. doi: 10.1371/journal.pone.0024837. Epub 2011 Sep 12.

3.

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis.

Michaud J, Wu F, Osato M, Cottles GM, Yanagida M, Asou N, Shigesada K, Ito Y, Benson KF, Raskind WH, Rossier C, Antonarakis SE, Israels S, McNicol A, Weiss H, Horwitz M, Scott HS.

Blood. 2002 Feb 15;99(4):1364-72.

4.

Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4.

Aneja K, Jalagadugula G, Mao G, Singh A, Rao AK.

J Thromb Haemost. 2011 Feb;9(2):383-91. doi: 10.1111/j.1538-7836.2010.04154.x.

5.

Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets.

Glembotsky AC, Bluteau D, Espasandin YR, Goette NP, Marta RF, Marin Oyarzun CP, Korin L, Lev PR, Laguens RP, Molinas FC, Raslova H, Heller PG.

J Thromb Haemost. 2014 May;12(5):761-72. doi: 10.1111/jth.12550.

6.

Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.

Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T.

Blood. 2003 Jun 15;101(12):4748-56. Epub 2003 Feb 27.

7.

Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation.

Heller PG, Glembotsky AC, Gandhi MJ, Cummings CL, Pirola CJ, Marta RF, Kornblihtt LI, Drachman JG, Molinas FC.

Blood. 2005 Jun 15;105(12):4664-70. Epub 2005 Mar 1.

8.

Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency.

Jalagadugula G, Mao G, Kaur G, Goldfinger LE, Dhanasekaran DN, Rao AK.

Blood. 2010 Dec 23;116(26):6037-45. doi: 10.1182/blood-2010-06-289850. Epub 2010 Sep 27.

9.

Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression.

Minami T, Tachibana K, Imanishi T, Doi T.

Eur J Biochem. 1998 Dec 1;258(2):879-89.

10.

Dynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line models.

Pencovich N, Jaschek R, Tanay A, Groner Y.

Blood. 2011 Jan 6;117(1):e1-14. doi: 10.1182/blood-2010-07-295113. Epub 2010 Oct 19.

11.

[Transcription factors responsible for megakaryocyte-specific gene expression].

Doi T.

Yakugaku Zasshi. 2005 Sep;125(9):685-97. Review. Japanese.

12.

Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients.

Sakurai M, Kunimoto H, Watanabe N, Fukuchi Y, Yuasa S, Yamazaki S, Nishimura T, Sadahira K, Fukuda K, Okano H, Nakauchi H, Morita Y, Matsumura I, Kudo K, Ito E, Ebihara Y, Tsuji K, Harada Y, Harada H, Okamoto S, Nakajima H.

Leukemia. 2014 Dec;28(12):2344-54. doi: 10.1038/leu.2014.136. Epub 2014 Apr 15.

PMID:
24732596
13.

Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy.

Owen CJ, Toze CL, Koochin A, Forrest DL, Smith CA, Stevens JM, Jackson SC, Poon MC, Sinclair GD, Leber B, Johnson PR, Macheta A, Yin JA, Barnett MJ, Lister TA, Fitzgibbon J.

Blood. 2008 Dec 1;112(12):4639-45. doi: 10.1182/blood-2008-05-156745. Epub 2008 Aug 21.

14.

RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation.

Elagib KE, Racke FK, Mogass M, Khetawat R, Delehanty LL, Goldfarb AN.

Blood. 2003 Jun 1;101(11):4333-41. Epub 2003 Feb 6.

15.

High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder.

Preudhomme C, Renneville A, Bourdon V, Philippe N, Roche-Lestienne C, Boissel N, Dhedin N, André JM, Cornillet-Lefebvre P, Baruchel A, Mozziconacci MJ, Sobol H.

Blood. 2009 May 28;113(22):5583-7. doi: 10.1182/blood-2008-07-168260. Epub 2009 Apr 8.

16.

The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors.

Cooper S, Guo H, Friedman AD.

PLoS One. 2015 May 4;10(5):e0126385. doi: 10.1371/journal.pone.0126385. eCollection 2015.

17.

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

Antony-Debré I, Bluteau D, Itzykson R, Baccini V, Renneville A, Boehlen F, Morabito M, Droin N, Deswarte C, Chang Y, Leverger G, Solary E, Vainchenker W, Favier R, Raslova H.

Blood. 2012 Sep 27;120(13):2719-22. Epub 2012 Jun 7.

18.

Functional characterization of the promoter region of the human EVI1 gene in acute myeloid leukemia: RUNX1 and ELK1 directly regulate its transcription.

Maicas M, Vázquez I, Vicente C, García-Sánchez MA, Marcotegui N, Urquiza L, Calasanz MJ, Odero MD.

Oncogene. 2013 Apr 18;32(16):2069-78. doi: 10.1038/onc.2012.222. Epub 2012 Jun 11.

PMID:
22689058
19.

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression.

Bluteau D, Glembotsky AC, Raimbault A, Balayn N, Gilles L, Rameau P, Nurden P, Alessi MC, Debili N, Vainchenker W, Heller PG, Favier R, Raslova H.

Blood. 2012 Sep 27;120(13):2708-18. Epub 2012 Aug 16.

20.

Cell-autonomous function of Runx1 transcriptionally regulates mouse megakaryocytic maturation.

Pencovich N, Jaschek R, Dicken J, Amit A, Lotem J, Tanay A, Groner Y.

PLoS One. 2013 May 23;8(5):e64248. doi: 10.1371/journal.pone.0064248. Print 2013.

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