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Items: 1 to 20 of 92

1.

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target.

Fang W, Du T, Raimi OG, Hurtado-Guerrero R, Mariño K, Ibrahim AF, Albarbarawi O, Ferguson MA, Jin C, Van Aalten DM.

Biosci Rep. 2013 Sep 4;33(5). pii: e00063. doi: 10.1042/BSR20130053.

2.

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target.

Fang W, Du T, Raimi OG, Hurtado-Guerrero R, Urbaniak MD, Ibrahim AF, Ferguson MA, Jin C, van Aalten DM.

Mol Microbiol. 2013 Aug;89(3):479-93. doi: 10.1111/mmi.12290. Epub 2013 Jul 5.

3.

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.

Fang W, Robinson DA, Raimi OG, Blair DE, Harrison JR, Lockhart DE, Torrie LS, Ruda GF, Wyatt PG, Gilbert IH, van Aalten DM.

ACS Chem Biol. 2015 Jun 19;10(6):1425-34. doi: 10.1021/cb5008647. Epub 2015 Feb 27.

4.

Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.

Hurtado-Guerrero R, Raimi OG, Min J, Zeng H, Vallius L, Shepherd S, Ibrahim AF, Wu H, Plotnikov AN, van Aalten DM.

Biochem J. 2008 Oct 15;415(2):217-23. doi: 10.1042/BJ20081000.

PMID:
18601654
5.

Crystal structures and small-angle x-ray scattering analysis of UDP-galactopyranose mutase from the pathogenic fungus Aspergillus fumigatus.

Dhatwalia R, Singh H, Oppenheimer M, Karr DB, Nix JC, Sobrado P, Tanner JJ.

J Biol Chem. 2012 Mar 16;287(12):9041-51. doi: 10.1074/jbc.M111.327536. Epub 2012 Jan 31.

6.

Aspergillus nidulans cell wall composition and function change in response to hosting several Aspergillus fumigatus UDP-galactopyranose mutase activity mutants.

Alam MK, van Straaten KE, Sanders DA, Kaminskyj SG.

PLoS One. 2014 Jan 15;9(1):e85735. doi: 10.1371/journal.pone.0085735. eCollection 2014.

7.

Acetazolamide-based fungal chitinase inhibitors.

Schüttelkopf AW, Gros L, Blair DE, Frearson JA, van Aalten DM, Gilbert IH.

Bioorg Med Chem. 2010 Dec 1;18(23):8334-40. doi: 10.1016/j.bmc.2010.09.062. Epub 2010 Oct 8.

8.

Contribution of galactofuranose to the virulence of the opportunistic pathogen Aspergillus fumigatus.

Schmalhorst PS, Krappmann S, Vervecken W, Rohde M, Müller M, Braus GH, Contreras R, Braun A, Bakker H, Routier FH.

Eukaryot Cell. 2008 Aug;7(8):1268-77. doi: 10.1128/EC.00109-08. Epub 2008 Jun 13.

9.

Three-dimensional models of 14α-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction.

Alcazar-Fuoli L, Cuesta I, Rodriguez-Tudela JL, Cuenca-Estrella M, Sanglard D, Mellado E.

Int J Antimicrob Agents. 2011 Nov;38(5):426-34. doi: 10.1016/j.ijantimicag.2011.06.005. Epub 2011 Aug 25.

PMID:
21871783
10.

Contributions of unique active site residues of eukaryotic UDP-galactopyranose mutases to substrate recognition and active site dynamics.

Da Fonseca I, Qureshi IA, Mehra-Chaudhary R, Kizjakina K, Tanner JJ, Sobrado P.

Biochemistry. 2014 Dec 16;53(49):7794-804. doi: 10.1021/bi501008z. Epub 2014 Dec 2.

11.

Specific molecular features in the organization and biosynthesis of the cell wall of Aspergillus fumigatus.

Latgé JP, Mouyna I, Tekaia F, Beauvais A, Debeaupuis JP, Nierman W.

Med Mycol. 2005 May;43 Suppl 1:S15-22. Review.

PMID:
16110787
12.

Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus.

Bamford NC, Snarr BD, Gravelat FN, Little DJ, Lee MJ, Zacharias CA, Chabot JC, Geller AM, Baptista SD, Baker P, Robinson H, Howell PL, Sheppard DC.

J Biol Chem. 2015 Nov 13;290(46):27438-50. doi: 10.1074/jbc.M115.679050. Epub 2015 Sep 4.

13.

Repression of N-glycosylation triggers the unfolded protein response (UPR) and overexpression of cell wall protein and chitin in Aspergillus fumigatus.

Li K, Ouyang H, Lü Y, Liang J, Wilson IB, Jin C.

Microbiology. 2011 Jul;157(Pt 7):1968-79. doi: 10.1099/mic.0.047712-0. Epub 2011 Apr 28.

PMID:
21527474
14.

The chitin synthase genes chsA and chsC are not required for cell wall stress responses in the human pathogen Aspergillus fumigatus.

Rogg LE, Fortwendel JR, Juvvadi PR, Lilley A, Steinbach WJ.

Biochem Biophys Res Commun. 2011 Aug 5;411(3):549-54. doi: 10.1016/j.bbrc.2011.06.180. Epub 2011 Jul 5.

15.

Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.

Mabanglo MF, Hast MA, Lubock NB, Hellinga HW, Beese LS.

Protein Sci. 2014 Mar;23(3):289-301. doi: 10.1002/pro.2411. Epub 2014 Jan 31.

16.

Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus.

Juvvadi PR, Gehrke C, Fortwendel JR, Lamoth F, Soderblom EJ, Cook EC, Hast MA, Asfaw YG, Moseley MA, Creamer TP, Steinbach WJ.

PLoS Pathog. 2013;9(8):e1003564. doi: 10.1371/journal.ppat.1003564. Epub 2013 Aug 22.

17.

Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis.

Chilton AS, Ellis AL, Lamb AL.

Acta Crystallogr F Struct Biol Commun. 2014 Oct;70(Pt 10):1328-32. doi: 10.1107/S2053230X14018962. Epub 2014 Sep 25.

18.

Membrane and cell wall targets in Aspergillus fumigatus.

Beauvais A, Latgé JP.

Drug Resist Updat. 2001 Feb;4(1):38-49. Review.

PMID:
11512152
19.

AGS3, an alpha(1-3)glucan synthase gene family member of Aspergillus fumigatus, modulates mycelium growth in the lung of experimentally infected mice.

Maubon D, Park S, Tanguy M, Huerre M, Schmitt C, Prévost MC, Perlin DS, Latgé JP, Beauvais A.

Fungal Genet Biol. 2006 May;43(5):366-75. Epub 2006 Mar 13.

PMID:
16531086
20.

Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus.

Oppenheimer M, Poulin MB, Lowary TL, Helm RF, Sobrado P.

Arch Biochem Biophys. 2010 Oct 1;502(1):31-8. doi: 10.1016/j.abb.2010.06.035. Epub 2010 Jul 6.

PMID:
20615386

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