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Interaction of complement factor h and fibulin3 in age-related macular degeneration.

Wyatt MK, Tsai JY, Mishra S, Campos M, Jaworski C, Fariss RN, Bernstein SL, Wistow G.

PLoS One. 2013 Jun 28;8(6):e68088. doi: 10.1371/journal.pone.0068088. Print 2013.


Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid.

Johnson PT, Betts KE, Radeke MJ, Hageman GS, Anderson DH, Johnson LV.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17456-61. Epub 2006 Nov 1.


Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

Clark SJ, Perveen R, Hakobyan S, Morgan BP, Sim RB, Bishop PN, Day AJ.

J Biol Chem. 2010 Sep 24;285(39):30192-202. doi: 10.1074/jbc.M110.103986. Epub 2010 Jul 26.


Regulation of age-related macular degeneration-like pathology by complement factor H.

Toomey CB, Kelly U, Saban DR, Bowes Rickman C.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3040-9. doi: 10.1073/pnas.1424391112. Epub 2015 May 19.


The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning.

Mullins RF, Schoo DP, Sohn EH, Flamme-Wiese MJ, Workamelahu G, Johnston RM, Wang K, Tucker BA, Stone EM.

Am J Pathol. 2014 Nov;184(11):3142-53. doi: 10.1016/j.ajpath.2014.07.017. Epub 2014 Sep 7.


C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration.

Bhutto IA, Baba T, Merges C, Juriasinghani V, McLeod DS, Lutty GA.

Br J Ophthalmol. 2011 Sep;95(9):1323-30. doi: 10.1136/bjo.2010.199216. Epub 2011 Jun 1.


Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.

Radu RA, Hu J, Jiang Z, Bok D.

J Biol Chem. 2014 Mar 28;289(13):9113-20. doi: 10.1074/jbc.M114.548669. Epub 2014 Feb 18.


Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors.

An E, Lu X, Flippin J, Devaney JM, Halligan B, Hoffman EP, Strunnikova N, Csaky K, Hathout Y.

J Proteome Res. 2006 Oct;5(10):2599-610. Erratum in: J Proteome Res. 2007 Apr;6(4):1615. Strunnikova, Nataly [added]; Hoffman, Eric [corrected to Hoffman, Eric P].


CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye.

Wang JC, Cao S, Wang A, To E, Law G, Gao J, Zhang D, Cui JZ, Matsubara JA.

Mol Vis. 2015 Mar 13;21:264-72. eCollection 2015.


Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.

Clark SJ, Bishop PN, Day AJ.

Biochem Soc Trans. 2010 Oct;38(5):1342-8. doi: 10.1042/BST0381342. Review.


The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice.

Fu L, Garland D, Yang Z, Shukla D, Rajendran A, Pearson E, Stone EM, Zhang K, Pierce EA.

Hum Mol Genet. 2007 Oct 15;16(20):2411-22. Epub 2007 Jul 30.


Complement factor H, vitronectin, and opticin are tyrosine-sulfated proteins of the retinal pigment epithelium.

Kanan Y, Siefert JC, Kinter M, Al-Ubaidi MR.

PLoS One. 2014 Aug 19;9(8):e105409. doi: 10.1371/journal.pone.0105409. eCollection 2014.


Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration.

Marmorstein LY, Munier FL, Arsenijevic Y, Schorderet DF, McLaughlin PJ, Chung D, Traboulsi E, Marmorstein AD.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13067-72. Epub 2002 Sep 19.


Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration.

Kelly U, Yu L, Kumar P, Ding JD, Jiang H, Hageman GS, Arshavsky VY, Frank MM, Hauser MA, Rickman CB.

J Immunol. 2010 Nov 1;185(9):5486-94. doi: 10.4049/jimmunol.0903596. Epub 2010 Sep 27.


Altered gene expression in dry age-related macular degeneration suggests early loss of choroidal endothelial cells.

Whitmore SS, Braun TA, Skeie JM, Haas CM, Sohn EH, Stone EM, Scheetz TE, Mullins RF.

Mol Vis. 2013 Nov 16;19:2274-97. eCollection 2013.


Immunohistochemical localization of complement regulatory proteins in the human retina.

Fett AL, Hermann MM, Muether PS, Kirchhof B, Fauser S.

Histol Histopathol. 2012 Mar;27(3):357-64.


Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.

Faber C, Williams J, Juel HB, Greenwood J, Nissen MH, Moss SE.

Invest Ophthalmol Vis Sci. 2012 Sep 19;53(10):6324-30.


Complement factor H variant Y402H and basal laminar deposits in exudative age-related macular degeneration.

Lommatzsch A, Hermans P, Weber B, Pauleikhoff D.

Graefes Arch Clin Exp Ophthalmol. 2007 Nov;245(11):1713-6. Epub 2007 Aug 18.


The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.

Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, Curletti CR, Hancox LS, Hu J, Ebright JN, Malek G, Hauser MA, Rickman CB, Bok D, Hageman GS, Johnson LV.

Prog Retin Eye Res. 2010 Mar;29(2):95-112. doi: 10.1016/j.preteyeres.2009.11.003. Epub 2009 Dec 2. Review.

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