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Rhodiola crenulata and Its Bioactive Components, Salidroside and Tyrosol, Reverse the Hypoxia-Induced Reduction of Plasma-Membrane-Associated Na,K-ATPase Expression via Inhibition of ROS-AMPK-PKC ξ Pathway.

Lee SY, Shi LS, Chu H, Li MH, Ho CW, Lai FY, Huang CY, Chang TC.

Evid Based Complement Alternat Med. 2013;2013:284150. doi: 10.1155/2013/284150. Epub 2013 Jun 6.


Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.

Gusarova GA, Dada LA, Kelly AM, Brodie C, Witters LA, Chandel NS, Sznajder JI.

Mol Cell Biol. 2009 Jul;29(13):3455-64. doi: 10.1128/MCB.00054-09. Epub 2009 Apr 20.


Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway.

Hsu SW, Chang TC, Wu YK, Lin KT, Shi LS, Lee SY.

BMC Complement Altern Med. 2017 Jan 7;17(1):29. doi: 10.1186/s12906-016-1524-z.


Rhodiola crenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway.

Lee SY, Lai FY, Shi LS, Chou YC, Yen IC, Chang TC.

Phytomedicine. 2015 Apr 15;22(4):477-86. doi: 10.1016/j.phymed.2015.01.016. Epub 2015 Mar 11.


Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.

Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI.

J Clin Invest. 2003 Apr;111(7):1057-64.


Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats.

Lee SY, Li MH, Shi LS, Chu H, Ho CW, Chang TC.

Evid Based Complement Alternat Med. 2013;2013:718739. doi: 10.1155/2013/718739. Epub 2013 Apr 28.


AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.

Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI.

J Clin Invest. 2008 Feb;118(2):752-62. doi: 10.1172/JCI29723.


Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na,K-ATPase in A549 cells.

Dada LA, Novoa E, Lecuona E, Sun H, Sznajder JI.

J Cell Sci. 2007 Jul 1;120(Pt 13):2214-22. Epub 2007 Jun 5.


Hypoxic inhibition of alveolar fluid reabsorption.

Dada LA, Sznajder JI.

Adv Exp Med Biol. 2007;618:159-68. Review.


Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat.

Qu ZQ, Zhou Y, Zeng YS, Lin YK, Li Y, Zhong ZQ, Chan WY.

PLoS One. 2012;7(1):e29641. doi: 10.1371/journal.pone.0029641. Epub 2012 Jan 3.


Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.

Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI.

Mol Cell Biol. 2011 Sep;31(17):3546-56. doi: 10.1128/MCB.05114-11. Epub 2011 Jul 5.


Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia.

Mairbäurl H, Wodopia R, Eckes S, Schulz S, Bärtsch P.

Am J Physiol. 1997 Oct;273(4 Pt 1):L797-806.


Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia.

Dada LA, Welch LC, Zhou G, Ben-Saadon R, Ciechanover A, Sznajder JI.

Cell Signal. 2007 Sep;19(9):1893-8. Epub 2007 May 5.


Dexamethasone prevents transport inhibition by hypoxia in rat lung and alveolar epithelial cells by stimulating activity and expression of Na+-K+-ATPase and epithelial Na+ channels.

Güney S, Schuler A, Ott A, Höschele S, Zügel S, Baloglu E, Bärtsch P, Mairbäurl H.

Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1332-8. Epub 2007 Sep 14.


Inhibition of Na-K-ATPase activity after prolonged hypoxia in an alveolar epithelial cell line.

Planès C, Friedlander G, Loiseau A, Amiel C, Clerici C.

Am J Physiol. 1996 Jul;271(1 Pt 1):L70-8.


Regulation of Na,K-ATPase during acute lung injury.

Lecuona E, Trejo HE, Sznajder JI.

J Bioenerg Biomembr. 2007 Dec;39(5-6):391-5. Review.


Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.

Gille T, Randrianarison-Pellan N, Goolaerts A, Dard N, Uzunhan Y, Ferrary E, Hummler E, Clerici C, Planès C.

Am J Respir Cell Mol Biol. 2014 Mar;50(3):526-37. doi: 10.1165/rcmb.2012-0518OC.


Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species.

Chen Z, Krmar RT, Dada L, Efendiev R, Leibiger IB, Pedemonte CH, Katz AI, Sznajder JI, Bertorello AM.

Am J Respir Cell Mol Biol. 2006 Jul;35(1):127-32. Epub 2006 Feb 23.


[Prevention of Rhodiola-astragalus membranaceus compounds against simulated plateau hypoxia brain injury in rat].

Zhu L, Shi ZY, Wu XM, Zhang ZJ, Jin SY.

Space Med Med Eng (Beijing). 2005 Aug;18(4):303-5. Chinese.


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