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Involvement of the GluN2A and GluN2B subunits in synaptic and extrasynaptic N-methyl-D-aspartate receptor function and neuronal excitotoxicity.

Zhou X, Ding Q, Chen Z, Yun H, Wang H.

J Biol Chem. 2013 Aug 16;288(33):24151-9. doi: 10.1074/jbc.M113.482000. Epub 2013 Jul 9.


Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects.

Vizi ES, Kisfali M, Lőrincz T.

Brain Res Bull. 2013 Apr;93:32-8. doi: 10.1016/j.brainresbull.2012.10.005. Epub 2012 Oct 23. Review.


NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors.

Zhou X, Hollern D, Liao J, Andrechek E, Wang H.

Cell Death Dis. 2013 Mar 28;4:e560. doi: 10.1038/cddis.2013.82.


Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptors.

Wei G, Yin Y, Li W, Bito H, She H, Mao Z.

J Biol Chem. 2012 Feb 17;287(8):5797-805. doi: 10.1074/jbc.M111.260109. Epub 2012 Jan 3.


Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.

Hardingham GE, Fukunaga Y, Bading H.

Nat Neurosci. 2002 May;5(5):405-14.


Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia.

Vieira MM, Schmidt J, Ferreira JS, She K, Oku S, Mele M, Santos AE, Duarte CB, Craig AM, Carvalho AL.

Neurobiol Dis. 2016 May;89:223-34. doi: 10.1016/j.nbd.2015.11.007. Epub 2015 Nov 12.


Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice.

Milnerwood AJ, Kaufman AM, Sepers MD, Gladding CM, Zhang L, Wang L, Fan J, Coquinco A, Qiao JY, Lee H, Wang YT, Cynader M, Raymond LA.

Neurobiol Dis. 2012 Oct;48(1):40-51. doi: 10.1016/j.nbd.2012.05.013. Epub 2012 Jun 2.


Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons.

Lin CH, Chen CC, Chou CM, Wang CY, Hung CC, Chen JY, Chang HW, Chen YC, Yeh GC, Lee YH.

J Neurochem. 2009 Nov;111(3):777-89. doi: 10.1111/j.1471-4159.2009.06364.x. Epub 2009 Aug 27.


Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity.

Huang Y, Shen W, Su J, Cheng B, Li D, Liu G, Zhou WX, Zhang YX.

J Alzheimers Dis. 2017;57(3):885-897. doi: 10.3233/JAD-161186.


Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling.

Kunda S, Cheriyan J, Hur M, Balsara RD, Castellino FJ.

PLoS One. 2013 Nov 18;8(11):e81405. doi: 10.1371/journal.pone.0081405. eCollection 2013.


Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.

Kaufman AM, Milnerwood AJ, Sepers MD, Coquinco A, She K, Wang L, Lee H, Craig AM, Cynader M, Raymond LA.

J Neurosci. 2012 Mar 21;32(12):3992-4003. doi: 10.1523/JNEUROSCI.4129-11.2012.


Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits.

Delaney AJ, Sedlak PL, Autuori E, Power JM, Sah P.

J Neurophysiol. 2013 Mar;109(5):1391-402. doi: 10.1152/jn.00176.2012. Epub 2012 Dec 5.


Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures.

Ferreira IL, Bajouco LM, Mota SI, Auberson YP, Oliveira CR, Rego AC.

Cell Calcium. 2012 Feb;51(2):95-106. doi: 10.1016/j.ceca.2011.11.008. Epub 2011 Dec 15.


Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension.

Ye ZY, Li L, Li DP, Pan HL.

J Biol Chem. 2012 May 18;287(21):17438-46. doi: 10.1074/jbc.M111.331165. Epub 2012 Apr 3.


Co-activation of synaptic and extrasynaptic NMDA receptors by neuronal insults determines cell death in acute brain slice.

Chen Z, Zhou Q, Zhang M, Wang H, Yun W, Zhou X.

Neurochem Int. 2014 Dec;78:28-34. doi: 10.1016/j.neuint.2014.08.003. Epub 2014 Aug 22.


Cyclin D1 induction preceding neuronal death via the excitotoxic NMDA pathway involves selective stimulation of extrasynaptic NMDA receptors and JNK pathway.

Efthimiadi L, Farso M, Quirion R, Krantic S.

Neurodegener Dis. 2012;10(1-4):80-91. doi: 10.1159/000335911. Epub 2012 Feb 17.


GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome.

Ferreira JS, Schmidt J, Rio P, Águas R, Rooyakkers A, Li KW, Smit AB, Craig AM, Carvalho AL.

J Neurosci. 2015 Jun 3;35(22):8462-79. doi: 10.1523/JNEUROSCI.3567-14.2015.

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