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Items: 1 to 20 of 87

1.

Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors.

Wen W, Wu W, Romaine IM, Kaufmann K, Du Y, Sulikowski GA, Weaver CD, Lindsley CW.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4562-6. doi: 10.1016/j.bmcl.2013.06.023. Epub 2013 Jun 20.

2.

Discovery of potent and selective GIRK1/2 modulators via 'molecular switches' within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas.

Wen W, Wu W, Weaver CD, Lindsley CW.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5102-6. doi: 10.1016/j.bmcl.2014.08.061. Epub 2014 Sep 16.

PMID:
25264075
3.

Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.

Ramos-Hunter SJ, Engers DW, Kaufmann K, Du Y, Lindsley CW, Weaver CD, Sulikowski GA.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5195-8. doi: 10.1016/j.bmcl.2013.07.002. Epub 2013 Jul 18.

4.

Discovery and Characterization of a Selective Activator of the G-Protein Activated Inward-Rectifying Potassium (GIRK) Channel.

Days E, Kaufmann K, Romaine I, Niswender C, Lewis M, Utley T, Du Y, Sliwoski G, Morrison R, Dawson ES, Engers JL, Denton J, Daniels JS, Sulikowski GA, Lindsley CW, Weaver CD.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 6 [updated 2013 Mar 14].

5.

Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3.

Jelacic TM, Kennedy ME, Wickman K, Clapham DE.

J Biol Chem. 2000 Nov 17;275(46):36211-6.

6.

Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.

Wydeven N, Young D, Mirkovic K, Wickman K.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21492-7. doi: 10.1073/pnas.1212019110. Epub 2012 Dec 10.

7.

Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines.

Plummer HK 3rd, Dhar MS, Cekanova M, Schuller HM.

BMC Cancer. 2005 Aug 18;5:104.

9.
10.

Structural basis for modulation of gating property of G protein-gated inwardly rectifying potassium ion channel (GIRK) by i/o-family G protein α subunit (Gαi/o).

Mase Y, Yokogawa M, Osawa M, Shimada I.

J Biol Chem. 2012 Jun 1;287(23):19537-49. doi: 10.1074/jbc.M112.353888. Epub 2012 Apr 16.

11.

Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit.

Chan KW, Sui JL, Vivaudou M, Logothetis DE.

Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14193-8.

12.

The sensitivity of G protein-activated K+ channels toward halothane is essentially determined by the C terminus.

Milovic S, Steinecker-Frohnwieser B, Schreibmayer W, Weigl LG.

J Biol Chem. 2004 Aug 13;279(33):34240-9. Epub 2004 Jun 2.

13.
14.

Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits.

Lei Q, Jones MB, Talley EM, Schrier AD, McIntire WE, Garrison JC, Bayliss DA.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9771-6.

15.

Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.

Pravetoni M, Wickman K.

Genes Brain Behav. 2008 Jul;7(5):523-31. doi: 10.1111/j.1601-183X.2008.00388.x.

16.

Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil.

Kobayashi T, Washiyama K, Ikeda K.

Neuropsychopharmacology. 2006 Mar;31(3):516-24.

17.

Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.

Fernández-Alacid L, Watanabe M, Molnár E, Wickman K, Luján R.

Eur J Neurosci. 2011 Dec;34(11):1724-36. doi: 10.1111/j.1460-9568.2011.07886.x. Epub 2011 Nov 18.

18.

Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297.

Wydeven N, Marron Fernandez de Velasco E, Du Y, Benneyworth MA, Hearing MC, Fischer RA, Thomas MJ, Weaver CD, Wickman K.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10755-60. doi: 10.1073/pnas.1405190111. Epub 2014 Jul 7.

19.

Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine.

Kobayashi T, Washiyama K, Ikeda K.

Neuropsychopharmacology. 2010 Jun;35(7):1560-9. doi: 10.1038/npp.2010.27. Epub 2010 Mar 10.

20.

Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine.

Kobayashi T, Washiyama K, Ikeda K.

J Pharmacol Sci. 2006 Nov;102(3):278-87. Epub 2006 Oct 28.

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