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proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro.

Guo J, Wang J, Liang C, Yan J, Wang Y, Liu G, Jiang Z, Zhang L, Wang X, Wang Y, Zhou X, Liao H.

Stem Cell Res. 2013 Sep;11(2):874-87. doi: 10.1016/j.scr.2013.05.004. Epub 2013 May 21.


Type I interferons up-regulate the expression and signalling of p75 NTR/TrkA receptor complex in differentiated human SH-SY5Y neuroblastoma cells.

Dedoni S, Olianas MC, Ingianni A, Onali P.

Neuropharmacology. 2014 Apr;79:321-34. doi: 10.1016/j.neuropharm.2013.12.002. Epub 2013 Dec 11.


Nerve growth factor and proNGF simultaneously promote symmetric self-renewal, quiescence, and epithelial to mesenchymal transition to enlarge the breast cancer stem cell compartment.

Tomellini E, Touil Y, Lagadec C, Julien S, Ostyn P, Ziental-Gelus N, Meignan S, Lengrand J, Adriaenssens E, Polakowska R, Le Bourhis X.

Stem Cells. 2015 Feb;33(2):342-53. doi: 10.1002/stem.1849.


Molecular and structural insight into proNGF engagement of p75NTR and sortilin.

Feng D, Kim T, Ozkan E, Light M, Torkin R, Teng KK, Hempstead BL, Garcia KC.

J Mol Biol. 2010 Mar 5;396(4):967-84. doi: 10.1016/j.jmb.2009.12.030. Epub 2009 Dec 28.


Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.

Culmsee C, Gerling N, Lehmann M, Nikolova-Karakashian M, Prehn JH, Mattson MP, Krieglstein J.

Neuroscience. 2002;115(4):1089-108.


Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin.

Clewes O, Fahey MS, Tyler SJ, Watson JJ, Seok H, Catania C, Cho K, Dawbarn D, Allen SJ.

J Neurochem. 2008 Nov;107(4):1124-35. doi: 10.1111/j.1471-4159.2008.05698.x. Epub 2008 Sep 21.


NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling.

Bradshaw RA, Pundavela J, Biarc J, Chalkley RJ, Burlingame AL, Hondermarck H.

Adv Biol Regul. 2015 May;58:16-27. doi: 10.1016/j.jbior.2014.11.003. Epub 2014 Nov 20. Review.


Bone marrow stromal cell therapy reduces proNGF and p75 expression in mice with experimental autoimmune encephalomyelitis.

Zhang J, Brodie C, Li Y, Zheng X, Roberts C, Lu M, Gao Q, Borneman J, Savant-Bhonsale S, Elias SB, Chopp M.

J Neurol Sci. 2009 Apr 15;279(1-2):30-8. doi: 10.1016/j.jns.2008.12.033. Epub 2009 Feb 3.


The proNGF-p75NTR-sortilin signalling complex as new target for the therapeutic treatment of Parkinson's disease.

Chen LW, Yung KK, Chan YS, Shum DK, Bolam JP.

CNS Neurol Disord Drug Targets. 2008 Dec;7(6):512-23. Review.


Sortilin is essential for proNGF-induced neuronal cell death.

Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM.

Nature. 2004 Feb 26;427(6977):843-8.


ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism.

Howard L, Wyatt S, Nagappan G, Davies AM.

Development. 2013 May;140(10):2108-17. doi: 10.1242/dev.085266.


TAM receptors support neural stem cell survival, proliferation and neuronal differentiation.

Ji R, Meng L, Jiang X, Cvm NK, Ding J, Li Q, Lu Q.

PLoS One. 2014 Dec 16;9(12):e115140. doi: 10.1371/journal.pone.0115140. eCollection 2014.


p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB.

Ahmad I, Yue WY, Fernando A, Clark JJ, Woodson EA, Hansen MR.

Glia. 2014 Oct;62(10):1699-712. doi: 10.1002/glia.22709. Epub 2014 Jun 26.


Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM.

J Neurosci. 2006 May 17;26(20):5288-300. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.


ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels.

Ioannou MS, Fahnestock M.

Int J Mol Sci. 2017 Mar 9;18(3). pii: E599. doi: 10.3390/ijms18030599.


ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury.

Beattie MS, Harrington AW, Lee R, Kim JY, Boyce SL, Longo FM, Bresnahan JC, Hempstead BL, Yoon SO.

Neuron. 2002 Oct 24;36(3):375-86.


p75 Neurotrophin receptor signaling regulates hepatic myofibroblast proliferation and apoptosis in recovery from rodent liver fibrosis.

Kendall TJ, Hennedige S, Aucott RL, Hartland SN, Vernon MA, Benyon RC, Iredale JP.

Hepatology. 2009 Mar;49(3):901-10. doi: 10.1002/hep.22701.


Ketamine inhibits proliferation of neural stem cell from neonatal rat hippocampus in vitro.

Wu YQ, Liang T, Huang H, Zhu YZ, Zhao PP, Xu CM, Liu L, Shi XT, Hu Y, Huang L, Zhou CH.

Cell Physiol Biochem. 2014;34(5):1792-801. doi: 10.1159/000366379. Epub 2014 Nov 14.

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