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Items: 1 to 20 of 111

1.

7-(2-(4-(2-Fluoro-4-[123I]iodophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine.

Chopra A.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2013 Apr 22 [updated 2013 Jun 27].

2.

Synthesis and in vivo Evaluation of Fluorine-18 and Iodine-123 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as PET and SPECT Radiotracers for Mapping A2A Receptors.

Vala C, Morley TJ, Zhang X, Papin C, Tavares AA, Lee HS, Constantinescu C, Barret O, Carroll VM, Baldwin RM, Tamagnan GD, Alagille D.

ChemMedChem. 2016 Sep 6;11(17):1936-43. doi: 10.1002/cmdc.201600219. Epub 2016 Jul 13.

PMID:
27407017
3.

5-Amino-7-(3-(4-[11C]methoxy)phenylpropyl)-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine .

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2007 Jul 7 [updated 2008 Jul 8].

4.

[7-methyl-11C]-(E)-8-(3,4,5-Trimethoxystyryl)-1,3,7-trimethylxanthine.

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2006 Feb 17 [updated 2008 Jul 8].

5.

[4-O-methyl-11C]-8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione.

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2008 Sep 9 [updated 2008 Oct 15].

6.

Functional expression of adenosine A2A and A3 receptors in the mouse dendritic cell line XS-106.

Dickenson JM, Reeder S, Rees B, Alexander S, Kendall D.

Eur J Pharmacol. 2003 Aug 1;474(1):43-51.

PMID:
12909194
7.
8.

Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.

Baraldi PG, Fruttarolo F, Tabrizi MA, Preti D, Romagnoli R, El-Kashef H, Moorman A, Varani K, Gessi S, Merighi S, Borea PA.

J Med Chem. 2003 Mar 27;46(7):1229-41.

PMID:
12646033
9.

Synthesis and preclinical evaluation of 2-(2-furanyl)-7-[2-[4-[4-(2-[11C]methoxyethoxy)phenyl]-1-piperazinyl]ethyl]7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine-5-amine ([11C]Preladenant) as a PET tracer for the imaging of cerebral adenosine A2A receptors.

Zhou X, Khanapur S, Huizing AP, Zijlma R, Schepers M, Dierckx RA, van Waarde A, de Vries EF, Elsinga PH.

J Med Chem. 2014 Nov 13;57(21):9204-10. doi: 10.1021/jm501065t. Epub 2014 Oct 15.

PMID:
25279444
10.

[1-methyl-11C]8-Dicyclopropylmethyl-1-methyl-3-propylxanthine.

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2006 Feb 10 [updated 2008 Jul 6].

11.

Selective adenosine A2A receptor antagonists.

Ongini E, Monopoli A, Cacciari B, Baraldi PG.

Farmaco. 2001 Jan-Feb;56(1-2):87-90. Review.

PMID:
11347973
12.
13.

8-Cyclopentyl-3-(3-[18F]fluoropropyl)-1-propylxanthine.

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2006 Feb 13 [updated 2006 Jul 8].

14.

In vivo evaluation of [(123)I]MNI-420: a novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain.

Tavares AA, Batis J, Barret O, Alagille D, Vala C, Kudej G, Koren A, Cosgrove KP, Nice K, Kordower JH, Seibyl J, Tamagnan GD.

Nucl Med Biol. 2013 Apr;40(3):403-9. doi: 10.1016/j.nucmedbio.2012.12.005. Epub 2013 Jan 16.

PMID:
23332393
15.

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists.

Baraldi PG, Cacciari B, Spalluto G, Pineda de las Infantas y Villatoro MJ, Zocchi C, Dionisotti S, Ongini E.

J Med Chem. 1996 Mar 1;39(5):1164-71.

PMID:
8676354
16.

Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.

Baraldi PG, Cacciari B, Spalluto G, Bergonzoni M, Dionisotti S, Ongini E, Varani K, Borea PA.

J Med Chem. 1998 Jun 4;41(12):2126-33.

PMID:
9622554
17.

Adenosine A2A receptors enhance GABA transport into nerve terminals by restraining PKC inhibition of GAT-1.

Cristóvão-Ferreira S, Vaz SH, Ribeiro JA, Sebastião AM.

J Neurochem. 2009 Apr;109(2):336-47. doi: 10.1111/j.1471-4159.2009.05963.x. Epub 2009 Feb 7.

18.

Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.

Kim YC, de Zwart M, Chang L, Moro S, von Frijtag Drabbe Künzel JK, Melman N, IJzerman AP, Jacobson KA.

J Med Chem. 1998 Jul 16;41(15):2835-45.

PMID:
9667972
19.

The role of the adenosinergic system in lung fibrosis.

Della Latta V, Cabiati M, Rocchiccioli S, Del Ry S, Morales MA.

Pharmacol Res. 2013 Oct;76:182-9. doi: 10.1016/j.phrs.2013.08.004. Epub 2013 Aug 28. Review.

PMID:
23994158
20.

Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement disorders and depression.

Hodgson RA, Bertorelli R, Varty GB, Lachowicz JE, Forlani A, Fredduzzi S, Cohen-Williams ME, Higgins GA, Impagnatiello F, Nicolussi E, Parra LE, Foster C, Zhai Y, Neustadt BR, Stamford AW, Parker EM, Reggiani A, Hunter JC.

J Pharmacol Exp Ther. 2009 Jul;330(1):294-303. doi: 10.1124/jpet.108.149617. Epub 2009 Mar 30.

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