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Items: 1 to 20 of 147

1.

Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.

Vascotto C, Lirussi L, Poletto M, Tiribelli M, Damiani D, Fabbro D, Damante G, Demple B, Colombo E, Tell G.

Oncogene. 2014 May 29;33(22):2876-87. doi: 10.1038/onc.2013.251. Epub 2013 Jul 8. Erratum in: Oncogene. 2015 Jun;34(26):3482.

PMID:
23831574
2.

Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.

Poletto M, Lirussi L, Wilson DM 3rd, Tell G.

Mol Biol Cell. 2014 May;25(10):1641-52. doi: 10.1091/mbc.E13-12-0717. Epub 2014 Mar 19.

3.

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties.

Poletto M, Malfatti MC, Dorjsuren D, Scognamiglio PL, Marasco D, Vascotto C, Jadhav A, Maloney DJ, Wilson DM 3rd, Simeonov A, Tell G.

Mol Carcinog. 2016 May;55(5):688-704. doi: 10.1002/mc.22313. Epub 2015 Apr 11.

4.

Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.

Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G.

Mol Biol Cell. 2012 Oct;23(20):4079-96. doi: 10.1091/mbc.E12-04-0299. Epub 2012 Aug 23.

5.

Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1.

Balusu R, Fiskus W, Rao R, Chong DG, Nalluri S, Mudunuru U, Ma H, Chen L, Venkannagari S, Ha K, Abhyankar S, Williams C, McGuirk J, Khoury HJ, Ustun C, Bhalla KN.

Blood. 2011 Sep 15;118(11):3096-106. doi: 10.1182/blood-2010-09-309674. Epub 2011 Jun 30.

6.

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, Radicella JP, Kelley MR, D'Ambrosio C, Scaloni A, Quadrifoglio F, Tell G.

Mol Cell Biol. 2009 Apr;29(7):1834-54. doi: 10.1128/MCB.01337-08. Epub 2009 Feb 2.

7.

Expression and prognostic significance of APE1/Ref-1 and NPM1 proteins in high-grade ovarian serous cancer.

Londero AP, Orsaria M, Tell G, Marzinotto S, Capodicasa V, Poletto M, Vascotto C, Sacco C, Mariuzzi L.

Am J Clin Pathol. 2014 Mar;141(3):404-14. doi: 10.1309/AJCPIDKDLSGE26CX.

PMID:
24515769
8.

Nm23-H1 protein binds to APE1 at AP sites and stimulates AP endonuclease activity following ionizing radiation of the human lung cancer A549 cells.

Zhang ZM, Yang XQ, Wang D, Wang G, Yang ZZ, Qing Y, Yang ZX, Li MX, Xiang DB.

Cell Biochem Biophys. 2011 Dec;61(3):561-72. doi: 10.1007/s12013-011-9238-9.

PMID:
21769563
9.

Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma.

Xie J, Zhang L, Li M, Du J, Zhou L, Yang S, Zeng L, Li Z, Wang G, Wang D.

BMC Cancer. 2014 Jan 8;14:11. doi: 10.1186/1471-2407-14-11.

10.

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications.

Falini B, Bolli N, Liso A, Martelli MP, Mannucci R, Pileri S, Nicoletti I.

Leukemia. 2009 Oct;23(10):1731-43. doi: 10.1038/leu.2009.124. Epub 2009 Jun 11. Review.

PMID:
19516275
11.

Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro.

Li FF, Yi S, Wen L, He J, Yang LJ, Zhao J, Zhang BP, Cui GH, Chen Y.

Acta Pharmacol Sin. 2014 Jun;35(6):806-13. doi: 10.1038/aps.2014.25.

12.

Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.

Unnikrishnan A, Raffoul JJ, Patel HV, Prychitko TM, Anyangwe N, Meira LB, Friedberg EC, Cabelof DC, Heydari AR.

Free Radic Biol Med. 2009 Jun 1;46(11):1488-99. doi: 10.1016/j.freeradbiomed.2009.02.021. Epub 2009 Mar 3.

13.

A novel role for Gadd45α in base excision repair: modulation of APE1 activity by the direct interaction of Gadd45α with PCNA.

Kim HL, Kim SU, Seo YR.

Biochem Biophys Res Commun. 2013 May 3;434(2):185-90. doi: 10.1016/j.bbrc.2013.02.066. Epub 2013 Feb 26.

PMID:
23485469
14.

Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.

Luncsford PJ, Manvilla BA, Patterson DN, Malik SS, Jin J, Hwang BJ, Gunther R, Kalvakolanu S, Lipinski LJ, Yuan W, Lu W, Drohat AC, Lu AL, Toth EA.

DNA Repair (Amst). 2013 Dec;12(12):1043-52. doi: 10.1016/j.dnarep.2013.09.007. Epub 2013 Oct 24.

16.

Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons.

Singh S, Englander EW.

Free Radic Biol Med. 2012 Nov 1;53(9):1782-90. doi: 10.1016/j.freeradbiomed.2012.07.025. Epub 2012 Jul 27.

18.

Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation.

Yi S, Wen L, He J, Wang Y, Zhao F, Zhao J, Zhao Z, Cui G, Chen Y.

Ann Hematol. 2015 Feb;94(2):201-10. doi: 10.1007/s00277-014-2206-x. Epub 2014 Sep 23.

PMID:
25242579
19.

Imidazoquinoxaline derivative EAPB0503: A promising drug targeting mutant nucleophosmin 1 in acute myeloid leukemia.

Nabbouh AI, Hleihel RS, Saliba JL, Karam MM, Hamie MH, Wu HJM, Berthier CP, Tawil NM, Bonnet PA, Deleuze-Masquefa C, El Hajj HA.

Cancer. 2017 May 1;123(9):1662-1673. doi: 10.1002/cncr.30515. Epub 2017 Jan 5.

PMID:
28055106
20.

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