Similar articles for PMID: 23831134

Year	Number of Results
1952	1
1974	1
2004	2
2005	1
2006	1
2007	2
2008	5
2009	6
2010	9
2011	10
2012	11
2013	12
2014	4
2015	3
2016	2
2017	1
2019	1
2020	1
2024	0

1

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.

Dehmlow H, Alvarez Sánchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, Graf M, Martin RE, Obst Sander U, Raab S, Richter HG, Sewing S, Sprecher U, Ullmer C, Mattei P. Dehmlow H, et al. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4627-32. doi: 10.1016/j.bmcl.2013.06.017. Epub 2013 Jun 19. Bioorg Med Chem Lett. 2013. PMID: 23831134

2

Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release.

Ullmer C, Alvarez Sanchez R, Sprecher U, Raab S, Mattei P, Dehmlow H, Sewing S, Iglesias A, Beauchamp J, Conde-Knape K. Ullmer C, et al. Br J Pharmacol. 2013 Jun;169(3):671-84. doi: 10.1111/bph.12158. Br J Pharmacol. 2013. PMID: 23488746 Free PMC article.

3

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.

Phillips DP, Gao W, Yang Y, Zhang G, Lerario IK, Lau TL, Jiang J, Wang X, Nguyen DG, Bhat BG, Trotter C, Sullivan H, Welzel G, Landry J, Chen Y, Joseph SB, Li C, Gordon WP, Richmond W, Johnson K, Bretz A, Bursulaya B, Pan S, McNamara P, Seidel HM. Phillips DP, et al. J Med Chem. 2014 Apr 24;57(8):3263-82. doi: 10.1021/jm401731q. Epub 2014 Apr 4. J Med Chem. 2014. PMID: 24666203

4

Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes.

Xia Y, Chackalamannil S, Greenlee WJ, Jayne C, Neustadt B, Stamford A, Vaccaro H, Xu XL, Baker H, O'Neill K, Woods M, Hawes B, Kowalski T. Xia Y, et al. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3290-6. doi: 10.1016/j.bmcl.2011.04.035. Epub 2011 Apr 14. Bioorg Med Chem Lett. 2011. PMID: 21536438

5

Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice.

Briere DA, Ruan X, Cheng CC, Siesky AM, Fitch TE, Dominguez C, Sanfeliciano SG, Montero C, Suen CS, Xu Y, Coskun T, Michael MD. Briere DA, et al. PLoS One. 2015 Aug 27;10(8):e0136873. doi: 10.1371/journal.pone.0136873. eCollection 2015. PLoS One. 2015. PMID: 26312995 Free PMC article.

6

Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.

Evans KA, Budzik BW, Ross SA, Wisnoski DD, Jin J, Rivero RA, Vimal M, Szewczyk GR, Jayawickreme C, Moncol DL, Rimele TJ, Armour SL, Weaver SP, Griffin RJ, Tadepalli SM, Jeune MR, Shearer TW, Chen ZB, Chen L, Anderson DL, Becherer JD, De Los Frailes M, Colilla FJ. Evans KA, et al. J Med Chem. 2009 Dec 24;52(24):7962-5. doi: 10.1021/jm901434t. J Med Chem. 2009. PMID: 19902954

7

Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists.

Duan H, Ning M, Chen X, Zou Q, Zhang L, Feng Y, Zhang L, Leng Y, Shen J. Duan H, et al. J Med Chem. 2012 Dec 13;55(23):10475-89. doi: 10.1021/jm301071h. Epub 2012 Nov 29. J Med Chem. 2012. PMID: 23148522

8

Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.

Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV, Hudson BD, Zaibi M, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T. Christiansen E, et al. J Med Chem. 2013 Feb 14;56(3):982-92. doi: 10.1021/jm301470a. Epub 2013 Jan 22. J Med Chem. 2013. PMID: 23294321

9

Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.

Semple G, Fioravanti B, Pereira G, Calderon I, Uy J, Choi K, Xiong Y, Ren A, Morgan M, Dave V, Thomsen W, Unett DJ, Xing C, Bossie S, Carroll C, Chu ZL, Grottick AJ, Hauser EK, Leonard J, Jones RM. Semple G, et al. J Med Chem. 2008 Sep 11;51(17):5172-5. doi: 10.1021/jm8006867. Epub 2008 Aug 13. J Med Chem. 2008. PMID: 18698756

10

Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold.

Zhu J, Ning M, Guo C, Zhang L, Pan G, Leng Y, Shen J. Zhu J, et al. Eur J Med Chem. 2013 Nov;69:55-68. doi: 10.1016/j.ejmech.2013.07.050. Epub 2013 Aug 13. Eur J Med Chem. 2013. PMID: 24007860

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