Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 498

1.

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.

Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.

Neuroscience. 2013 Oct 10;250:8-19. doi: 10.1016/j.neuroscience.2013.06.049.

PMID:
23830905
2.

Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice.

Tanaka Y, Chambers JK, Matsuwaki T, Yamanouchi K, Nishihara M.

Acta Neuropathol Commun. 2014 Jul 15;2:78. doi: 10.1186/s40478-014-0078-x.

3.

Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice.

Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.

Neuroscience. 2013 Feb 12;231:49-60. doi: 10.1016/j.neuroscience.2012.11.032.

PMID:
23201826
4.

TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.

Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z, Wang G.

EMBO J. 2016 Jan 18;35(2):121-42. doi: 10.15252/embj.201591998.

5.

Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.

Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.

Acta Neuropathol. 2014;127(6):845-60. doi: 10.1007/s00401-014-1262-6.

PMID:
24619111
6.

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.

Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A.

EMBO J. 2012 Mar 7;31(5):1095-108. doi: 10.1038/emboj.2012.32.

7.

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.

Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Tripoli DL, Czerniewski L, Ballabio A, Cirrito JR, Diwan A, Lee JM.

J Neurosci. 2015 Sep 2;35(35):12137-51. doi: 10.1523/JNEUROSCI.0705-15.2015.

8.

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.

Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM.

Sci Signal. 2012 Jun 12;5(228):ra42. doi: 10.1126/scisignal.2002790.

9.

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.

Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T.

Mol Neurodegener. 2016 Jun 24;11(1):46. doi: 10.1186/s13024-016-0114-3.

10.

Increase of transcription factor EB (TFEB) and lysosomes in rat DRG neurons and their transportation to the central nerve terminal in dorsal horn after nerve injury.

Jung J, Uesugi N, Jeong NY, Park BS, Konishi H, Kiyama H.

Neuroscience. 2016 Jan 28;313:10-22. doi: 10.1016/j.neuroscience.2015.11.028.

PMID:
26601776
11.

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.

Zhou J, Tan SH, Nicolas V, Bauvy C, Yang ND, Zhang J, Xue Y, Codogno P, Shen HM.

Cell Res. 2013 Apr;23(4):508-23. doi: 10.1038/cr.2013.11.

12.

Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus.

Zhu S, Tai C, Petkau TL, Zhang S, Liao C, Dong Z, Wen W, Chang Q, Tian Wang Y, MacVicar BA, Leavitt BR, Jia W, Cynader MS.

Brain Res. 2013 Sep 12;1530:54-65. doi: 10.1016/j.brainres.2013.07.023.

PMID:
23887054
13.

Regulation of TFEB and V-ATPases by mTORC1.

Peña-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, Wolff NC, Tran TA, Zou L, Xie XJ, Corey DR, Brugarolas J.

EMBO J. 2011 Jul 29;30(16):3242-58. doi: 10.1038/emboj.2011.257.

14.

Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis.

Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Burchett JM, Schuler DR, Cirrito JR, Diwan A, Lee JM.

J Neurosci. 2014 Jul 16;34(29):9607-20. doi: 10.1523/JNEUROSCI.3788-13.2014.

15.

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.

Zhou X, Sun L, Bastos de Oliveira F, Qi X, Brown WJ, Smolka MB, Sun Y, Hu F.

J Cell Biol. 2015 Sep 14;210(6):991-1002. doi: 10.1083/jcb.201502029.

16.

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.

Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV Jr, Gan L.

Nat Med. 2014 Oct;20(10):1157-64. doi: 10.1038/nm.3672.

17.

Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders.

Ghosh A, Jana M, Modi K, Gonzalez FJ, Sims KB, Berry-Kravis E, Pahan K.

J Biol Chem. 2015 Apr 17;290(16):10309-24. doi: 10.1074/jbc.M114.610659.

18.

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.

Hum Mol Genet. 2017 Jan 10. pii: ddx011. doi: 10.1093/hmg/ddx011. [Epub ahead of print]

PMID:
28073925
19.

TFEB and the CLEAR network.

Settembre C, Medina DL.

Methods Cell Biol. 2015;126:45-62. doi: 10.1016/bs.mcb.2014.11.011.

PMID:
25665440
20.

The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.

Martina JA, Diab HI, Lishu L, Jeong-A L, Patange S, Raben N, Puertollano R.

Sci Signal. 2014 Jan 21;7(309):ra9. doi: 10.1126/scisignal.2004754.

Supplemental Content

Support Center