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Items: 1 to 20 of 153

1.

Toxoplasma gondii Proliferation Require Down-Regulation of Host Nox4 Expression via Activation of PI3 Kinase/Akt Signaling Pathway.

Zhou W, Quan JH, Lee YH, Shin DW, Cha GH.

PLoS One. 2013 Jun 18;8(6):e66306. doi: 10.1371/journal.pone.0066306. Print 2013.

2.

Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway.

Zhou W, Quan JH, Gao FF, Ismail HAHA, Lee YH, Cha GH.

Korean J Parasitol. 2018 Apr;56(2):135-145. doi: 10.3347/kjp.2018.56.2.135. Epub 2018 Apr 30.

3.

Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells.

Quan JH, Chu JQ, Kwon J, Choi IW, Ismail HA, Zhou W, Cha GH, Zhou Y, Yuk JM, Jo EK, Lee YH.

PLoS One. 2015 Nov 3;10(11):e0141550. doi: 10.1371/journal.pone.0141550. eCollection 2015.

4.

Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis.

Quan JH, Cha GH, Zhou W, Chu JQ, Nishikawa Y, Lee YH.

Exp Parasitol. 2013 Apr;133(4):462-71. doi: 10.1016/j.exppara.2013.01.005. Epub 2013 Jan 16.

PMID:
23333591
5.

NADPH oxidase 4 is required for the generation of macrophage migration inhibitory factor and host defense against Toxoplasma gondii infection.

Kim JH, Lee J, Bae SJ, Kim Y, Park BJ, Choi JW, Kwon J, Cha GH, Yoo HJ, Jo EK, Bae YS, Lee YH, Yuk JM.

Sci Rep. 2017 Jul 25;7(1):6361. doi: 10.1038/s41598-017-06610-4.

6.

Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells.

Usatyuk PV, Fu P, Mohan V, Epshtein Y, Jacobson JR, Gomez-Cambronero J, Wary KK, Bindokas V, Dudek SM, Salgia R, Garcia JG, Natarajan V.

J Biol Chem. 2014 May 9;289(19):13476-91. doi: 10.1074/jbc.M113.527556. Epub 2014 Mar 14.

7.

Reactive oxygen species generation mediated by NADPH oxidase and PI3K/Akt pathways contribute to invasion of Streptococcus agalactiae in human endothelial cells.

Oliveira JSS, Santos GDS, Moraes JA, Saliba AM, Barja-Fidalgo TC, Mattos-Guaraldi AL, Nagao PE.

Mem Inst Oswaldo Cruz. 2018;113(6):e140421. doi: 10.1590/0074-02760170421. Epub 2018 Apr 5.

8.

Toxoplasma gondii protects against H(2)O(2) -induced apoptosis in ARPE-19 cells through the transcriptional regulation of apoptotic elements and downregulation of the p38 MAPK pathway.

Choi SH, Park SJ, Cha GH, Quan JH, Chang NS, Ahn MH, Shin DW, Lee YH.

Acta Ophthalmol. 2011 Jun;89(4):e350-6. doi: 10.1111/j.1755-3768.2011.02113.x. Epub 2011 Feb 25.

9.

Endogenous Hydrogen Sulfide Ameliorates NOX4 Induced Oxidative Stress in LPS-Stimulated Macrophages and Mice.

Wang XL, Pan LL, Long F, Wu WJ, Yan D, Xu P, Liu SY, Qin M, Jia WW, Liu XH, Zu YZ.

Cell Physiol Biochem. 2018;47(2):458-474. doi: 10.1159/000489980. Epub 2018 May 22.

10.

Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis.

Basuroy S, Tcheranova D, Bhattacharya S, Leffler CW, Parfenova H.

Am J Physiol Cell Physiol. 2011 Feb;300(2):C256-65. doi: 10.1152/ajpcell.00272.2010. Epub 2010 Dec 1.

11.

Silencing of NADPH Oxidase 4 Attenuates Hypoxia Resistance in Neuroblastoma Cells SH-SY5Y by Inhibiting PI3K/Akt-Dependent Glycolysis.

Yu T, Li L, Liu W, Ya B, Cheng H, Xin Q.

Oncol Res. 2019 May 7;27(5):525-532. doi: 10.3727/096504018X15179668157803. Epub 2018 Feb 9.

PMID:
29426376
12.

Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity.

Yang CS, Yuk JM, Lee YH, Jo EK.

Infect Immun. 2015 Nov 9;84(1):339-50. doi: 10.1128/IAI.00734-15. Print 2016 Jan.

13.

NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling.

Zhang C, Lan T, Hou J, Li J, Fang R, Yang Z, Zhang M, Liu J, Liu B.

Oncotarget. 2014 Jun 30;5(12):4392-405.

14.

Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells.

Silva A, Gírio A, Cebola I, Santos CI, Antunes F, Barata JT.

Leukemia. 2011 Jun;25(6):960-7. doi: 10.1038/leu.2011.56. Epub 2011 Apr 1.

PMID:
21455214
15.

NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages.

Matta SK, Patten K, Wang Q, Kim BH, MacMicking JD, Sibley LD.

MBio. 2018 Aug 28;9(4). pii: e01393-18. doi: 10.1128/mBio.01393-18.

16.

NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3.

Ismail S, Sturrock A, Wu P, Cahill B, Norman K, Huecksteadt T, Sanders K, Kennedy T, Hoidal J.

Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L489-99. doi: 10.1152/ajplung.90488.2008. Epub 2008 Nov 26.

17.

NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells.

Zeng C, Wu Q, Wang J, Yao B, Ma L, Yang Z, Li J, Liu B.

Free Radic Biol Med. 2016 Dec;101:236-248. doi: 10.1016/j.freeradbiomed.2016.10.500. Epub 2016 Oct 27.

PMID:
27989748
18.

NOX2, NOX4, and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in endothelial cells.

Harel S, Mayaki D, Sanchez V, Hussain SNA.

Vascul Pharmacol. 2017 May;92:22-32. doi: 10.1016/j.vph.2017.03.002. Epub 2017 Mar 27.

PMID:
28351775
19.

PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression.

Zhu M, Liu X, Wang S, Miao J, Wu L, Yang X, Wang Y, Kang L, Li W, Cui C, Chen H, Sang A.

Mol Vis. 2016 Dec 2;22:1361-1374. eCollection 2016.

20.

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