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Items: 1 to 20 of 105

1.

MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro.

Mehi SJ, Maltare A, Abraham CR, King GD.

Age (Dordr). 2014 Feb;36(1):141-9. doi: 10.1007/s11357-013-9555-6. Epub 2013 Jul 2.

2.

Intracellular signaling of the aging suppressor protein Klotho.

Sopjani M, Rinnerthaler M, Kruja J, Dermaku-Sopjani M.

Curr Mol Med. 2015;15(1):27-37. Review.

PMID:
25601466
3.

Klotho, stem cells, and aging.

Bian A, Neyra JA, Zhan M, Hu MC.

Clin Interv Aging. 2015 Aug 4;10:1233-43. doi: 10.2147/CIA.S84978. eCollection 2015. Review.

4.

Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1.

Zhou X, Yang Q, Xie Y, Sun J, Hu J, Qiu P, Cao W, Wang S.

Neurobiol Aging. 2015 Mar;36(3):1462-70. doi: 10.1016/j.neurobiolaging.2014.11.002. Epub 2014 Dec 18.

PMID:
25595496
5.

The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells.

Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J.

Arthritis Res Ther. 2012 May 2;14(3):R105. doi: 10.1186/ar3830.

6.

Suppression of aging in mice by the hormone Klotho.

Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M.

Science. 2005 Sep 16;309(5742):1829-33. Epub 2005 Aug 25.

7.

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma.

Lee J, Jeong DJ, Kim J, Lee S, Park JH, Chang B, Jung SI, Yi L, Han Y, Yang Y, Kim KI, Lim JS, Yang I, Jeon S, Bae DH, Kim CJ, Lee MS.

Mol Cancer. 2010 May 18;9:109. doi: 10.1186/1476-4598-9-109.

8.

Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging.

Bartke A.

Trends Endocrinol Metab. 2006 Mar;17(2):33-5. Epub 2006 Feb 3.

PMID:
16458526
10.

The aging suppressor klotho: a potential regulator of growth hormone secretion.

Shahmoon S, Rubinfeld H, Wolf I, Cohen ZR, Hadani M, Shimon I, Rubinek T.

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E326-34. doi: 10.1152/ajpendo.00090.2014. Epub 2014 Jun 17.

11.

Effects of intra- and extracellular factors on anti-aging klotho gene expression.

Turan K, Ata P.

Genet Mol Res. 2011 Sep 9;10(3):2009-23. doi: 10.4238/vol10-3gmr1261.

12.

Molecular basis of Klotho: from gene to function in aging.

Xu Y, Sun Z.

Endocr Rev. 2015 Apr;36(2):174-93. doi: 10.1210/er.2013-1079. Epub 2015 Feb 19. Review.

13.

Establishment of a cell-based assay to screen regulators for Klotho gene promoter.

Xu ZL, Gao H, Ou-Yang KQ, Cai SX, Hu YH.

Acta Pharmacol Sin. 2004 Sep;25(9):1165-70.

14.

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer.

Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, Kuro-o M, Karlan B, Kaufman B, Koeffler HP, Rubinek T.

Oncogene. 2008 Nov 27;27(56):7094-105. doi: 10.1038/onc.2008.292. Epub 2008 Sep 1.

PMID:
18762812
15.

Klotho: a novel biomarker for cancer.

Zhou X, Wang X.

J Cancer Res Clin Oncol. 2015 Jun;141(6):961-9. doi: 10.1007/s00432-014-1788-y. Epub 2014 Aug 3. Review.

PMID:
25086986
16.

Current understanding of klotho.

Wang Y, Sun Z.

Ageing Res Rev. 2009 Jan;8(1):43-51. doi: 10.1016/j.arr.2008.10.002. Epub 2008 Oct 31. Review.

17.

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549.

Chen B, Wang X, Zhao W, Wu J.

J Exp Clin Cancer Res. 2010 Jul 19;29:99. doi: 10.1186/1756-9966-29-99.

18.

Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway.

de Oliveira RM.

FEBS Lett. 2006 Oct 16;580(24):5753-8. Epub 2006 Sep 27.

19.

Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice.

Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N, Takahashi M, Boothman DA, Kuro-o M.

J Biol Chem. 2011 Mar 11;286(10):8655-65. doi: 10.1074/jbc.M110.174037. Epub 2011 Jan 5.

20.

Promoter methylation and age-related downregulation of Klotho in rhesus monkey.

King GD, Rosene DL, Abraham CR.

Age (Dordr). 2012 Dec;34(6):1405-19. doi: 10.1007/s11357-011-9315-4. Epub 2011 Sep 16.

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