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Items: 1 to 20 of 291

1.

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation.

Su YC, Qi X.

Hum Mol Genet. 2013 Nov 15;22(22):4545-61. doi: 10.1093/hmg/ddt301. Epub 2013 Jun 27.

PMID:
23813973
2.

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

Qi X, Qvit N, Su YC, Mochly-Rosen D.

J Cell Sci. 2013 Feb 1;126(Pt 3):789-802. doi: 10.1242/jcs.114439. Epub 2012 Dec 13.

3.

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells.

Plowey ED, Cherra SJ 3rd, Liu YJ, Chu CT.

J Neurochem. 2008 May;105(3):1048-56. doi: 10.1111/j.1471-4159.2008.05217.x. Epub 2008 Jan 7.

4.

ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression.

Zhu Y, Wang C, Yu M, Cui J, Liu L, Xu Z.

Protein Cell. 2013 Sep;4(9):711-21. doi: 10.1007/s13238-013-3910-3. Epub 2013 Sep 10.

5.

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.

Wang X, Yan MH, Fujioka H, Liu J, Wilson-Delfosse A, Chen SG, Perry G, Casadesus G, Zhu X.

Hum Mol Genet. 2012 May 1;21(9):1931-44. doi: 10.1093/hmg/dds003. Epub 2012 Jan 6.

6.

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.

Niu J, Yu M, Wang C, Xu Z.

J Neurochem. 2012 Aug;122(3):650-8. doi: 10.1111/j.1471-4159.2012.07809.x. Epub 2012 Jun 22.

7.

Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy.

Su YC, Guo X, Qi X.

Biochim Biophys Acta. 2015 Jan;1852(1):12-21. doi: 10.1016/j.bbadis.2014.11.009. Epub 2014 Nov 15.

8.

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.

Stafa K, Tsika E, Moser R, Musso A, Glauser L, Jones A, Biskup S, Xiong Y, Bandopadhyay R, Dawson VL, Dawson TM, Moore DJ.

Hum Mol Genet. 2014 Apr 15;23(8):2055-77. doi: 10.1093/hmg/ddt600. Epub 2013 Nov 26.

9.

Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.

Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X.

J Clin Invest. 2013 Dec;123(12):5371-88. doi: 10.1172/JCI70911. Epub 2013 Nov 15.

10.

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.

Tsika E, Nguyen AP, Dusonchet J, Colin P, Schneider BL, Moore DJ.

Neurobiol Dis. 2015 May;77:49-61. doi: 10.1016/j.nbd.2015.02.019. Epub 2015 Feb 28.

PMID:
25731749
11.

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

Saez-Atienzar S, Bonet-Ponce L, Blesa JR, Romero FJ, Murphy MP, Jordan J, Galindo MF.

Cell Death Dis. 2014 Aug 14;5:e1368. doi: 10.1038/cddis.2014.320.

12.

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.

Papkovskaia TD, Chau KY, Inesta-Vaquera F, Papkovsky DB, Healy DG, Nishio K, Staddon J, Duchen MR, Hardy J, Schapira AH, Cooper JM.

Hum Mol Genet. 2012 Oct 1;21(19):4201-13. doi: 10.1093/hmg/dds244. Epub 2012 Jun 26.

13.

G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.

Yakhine-Diop SM, Bravo-San Pedro JM, Gómez-Sánchez R, Pizarro-Estrella E, Rodríguez-Arribas M, Climent V, Aiastui A, López de Munain A, Fuentes JM, González-Polo RA.

Toxicology. 2014 Oct 3;324:1-9. doi: 10.1016/j.tox.2014.07.001. Epub 2014 Jul 10.

PMID:
25017139
14.

14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.

Lavalley NJ, Slone SR, Ding H, West AB, Yacoubian TA.

Hum Mol Genet. 2016 Jan 1;25(1):109-22. doi: 10.1093/hmg/ddv453. Epub 2015 Nov 5.

15.

Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.

Schwab AJ, Ebert AD.

Stem Cell Reports. 2015 Dec 8;5(6):1039-52. doi: 10.1016/j.stemcr.2015.11.004.

16.

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

Mortiboys H, Johansen KK, Aasly JO, Bandmann O.

Neurology. 2010 Nov 30;75(22):2017-20. doi: 10.1212/WNL.0b013e3181ff9685.

PMID:
21115957
17.

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis.

Kim DI, Lee KH, Gabr AA, Choi GE, Kim JS, Ko SH, Han HJ.

Biochim Biophys Acta. 2016 Nov;1863(11):2820-2834. doi: 10.1016/j.bbamcr.2016.09.003. Epub 2016 Sep 4.

PMID:
27599716
18.

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.

Bravo-San Pedro JM, Niso-Santano M, Gómez-Sánchez R, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA.

Cell Mol Life Sci. 2013 Jan;70(1):121-36. doi: 10.1007/s00018-012-1061-y. Epub 2012 Jul 8.

PMID:
22773119
19.

Does uncoupling protein 2 expression qualify as marker of disease status in LRRK2-associated Parkinson's disease?

Grünewald A, Arns B, Meier B, Brockmann K, Tadic V, Klein C.

Antioxid Redox Signal. 2014 May 1;20(13):1955-60. doi: 10.1089/ars.2013.5737. Epub 2014 Mar 7.

20.

UDCA exerts beneficial effect on mitochondrial dysfunction in LRRK2(G2019S) carriers and in vivo.

Mortiboys H, Furmston R, Bronstad G, Aasly J, Elliott C, Bandmann O.

Neurology. 2015 Sep 8;85(10):846-52. doi: 10.1212/WNL.0000000000001905. Epub 2015 Aug 7.

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