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N-acetylglucosaminyltransferase V confers hepatoma cells with resistance to anoikis through EGFR/PAK1 activation.

Liu J, Liu H, Zhang W, Wu Q, Liu W, Liu Y, Pan D, Xu J, Gu J.

Glycobiology. 2013 Sep;23(9):1097-109. doi: 10.1093/glycob/cwt049. Epub 2013 Jun 27.


Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma.

Chen L, Liu H, Liu J, Zhu Y, Xu L, He H, Zhang H, Wang S, Wu Q, Liu W, Liu Y, Pan D, Ren S, Xu J, Gu J.

PLoS One. 2013;8(3):e58413. doi: 10.1371/journal.pone.0058413. Epub 2013 Mar 13.


Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1.

Xu J, Liu H, Chen L, Wang S, Zhou L, Yun X, Sun L, Wen Y, Gu J.

Gastroenterology. 2012 Jul;143(1):199-212.e4. doi: 10.1053/j.gastro.2012.03.053. Epub 2012 Apr 5.


p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activation in renal cell carcinoma.

Zhu Y, Liu H, Xu L, An H, Liu W, Liu Y, Lin Z, Xu J.

Cell Death Dis. 2015 Feb 12;6:e1637. doi: 10.1038/cddis.2015.2.


The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells.

Yang Z, Bagheri-Yarmand R, Wang RA, Adam L, Papadimitrakopoulou VV, Clayman GL, El-Naggar A, Lotan R, Barnes CJ, Hong WK, Kumar R.

Clin Cancer Res. 2004 Jan 15;10(2):658-67.


Caveolin-1 Confers Resistance of Hepatoma Cells to Anoikis by Activating IGF-1 Pathway.

Tang W, Feng X, Zhang S, Ren Z, Liu Y, Yang B, lv B, Cai Y, Xia J, Ge N.

Cell Physiol Biochem. 2015;36(3):1223-36. doi: 10.1159/000430292. Epub 2015 Jun 30.


Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma.

Kesanakurti D, Chetty C, Rajasekhar Maddirela D, Gujrati M, Rao JS.

Cell Death Dis. 2012 Dec 20;3:e445. doi: 10.1038/cddis.2012.182.


Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis.

Menard RE, Jovanovski AP, Mattingly RR.

Neoplasia. 2005 Jul;7(7):638-45.


Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells.

Fuchs BC, Fujii T, Dorfman JD, Goodwin JM, Zhu AX, Lanuti M, Tanabe KK.

Cancer Res. 2008 Apr 1;68(7):2391-9. doi: 10.1158/0008-5472.CAN-07-2460.


N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells.

Morgan R, Gao G, Pawling J, Dennis JW, Demetriou M, Li B.

J Immunol. 2004 Dec 15;173(12):7200-8.


A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.

Wang D, Paria BC, Zhang Q, Karpurapu M, Li Q, Gerthoffer WT, Nakaoka Y, Rao GN.

Circ Res. 2009 May 8;104(9):1066-75. doi: 10.1161/CIRCRESAHA.109.196691. Epub 2009 Apr 9.


HDGF-related protein-3 is required for anchorage-independent survival and chemoresistance in hepatocellular carcinomas.

Xiao Q, Qu K, Wang C, Kong Y, Liu C, Jiang D, Saiyin H, Jia F, Ni C, Chen T, Zhang Y, Zhang P, Qin W, Sun Q, Wang H, Yi Q, Liu J, Huang H, Yu L.

Gut. 2013 Mar;62(3):440-51. doi: 10.1136/gutjnl-2011-300781. Epub 2012 Apr 5.


Thrombin stimulation of inflammatory breast cancer cells leads to aggressiveness via the EGFR-PAR1-Pak1 pathway.

Ohshiro K, Bui-Nguyen TM, Divijendra Natha RS, Schwartz AM, Levine P, Kumar R.

Int J Biol Markers. 2012 Dec 27;27(4):e305-13. doi: 10.5301/JBM.2012.10437.


Tumor Suppressive Function of p21-activated Kinase 6 in Hepatocellular Carcinoma.

Liu W, Liu Y, Liu H, Zhang W, Fu Q, Xu J, Gu J.

J Biol Chem. 2015 Nov 20;290(47):28489-501. doi: 10.1074/jbc.M115.658237. Epub 2015 Oct 6.


Mitogen-activated protein kinase pathway is pivotal for anoikis resistance in metastatic hepatoma cells.

Cao L, Zhang Z, Han L, Du J, Liang X, Liu Y, Sun W.

Mol Med Rep. 2014 Apr;9(4):1121-7. doi: 10.3892/mmr.2014.1952. Epub 2014 Feb 14.


Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.

Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, Sahin A, Chernoff J, Hung MC, Kumar R.

J Biol Chem. 2000 Nov 17;275(46):36238-44.


Complex N-glycan and metabolic control in tumor cells.

Mendelsohn R, Cheung P, Berger L, Partridge E, Lau K, Datti A, Pawling J, Dennis JW.

Cancer Res. 2007 Oct 15;67(20):9771-80.


Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene.

Yoshii S, Tanaka M, Otsuki Y, Fujiyama T, Kataoka H, Arai H, Hanai H, Sugimura H.

Mol Cell Biol. 2001 Oct;21(20):6796-807.

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