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Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction.

Qu K, Shen NY, Xu XS, Su HB, Wei JC, Tai MH, Meng FD, Zhou L, Zhang YL, Liu C.

Acta Pharmacol Sin. 2013 Sep;34(9):1217-28. doi: 10.1038/aps.2013.58. Epub 2013 Jul 1.


Emodin induces apoptosis of human osteosarcoma cells via mitochondria- and endoplasmic reticulum stress-related pathways.

Ying J, Xu H, Wu D, Wu X.

Int J Clin Exp Pathol. 2015 Oct 1;8(10):12837-44. eCollection 2015.


Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways.

Lin SY, Lai WW, Ho CC, Yu FS, Chen GW, Yang JS, Liu KC, Lin ML, Wu PP, Fan MJ, Chung JG.

Anticancer Res. 2009 Jan;29(1):327-35.


Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway.

Dong X, Fu J, Yin X, Qu C, Yang C, He H, Ni J.

Cell Physiol Biochem. 2017;42(2):685-696. doi: 10.1159/000477886. Epub 2017 Jun 15.


Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway.

Lian LH, Park EJ, Piao HS, Zhao YZ, Sohn DH.

Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):495-502.


Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated Bid cleavage.

Yan Y, Su X, Liang Y, Zhang J, Shi C, Lu Y, Gu L, Fu L.

Mol Cancer Ther. 2008 Jun;7(6):1688-97. doi: 10.1158/1535-7163.MCT-07-2362.


The predominant pathway of apoptosis in THP-1 macrophage-derived foam cells induced by 5-aminolevulinic acid-mediated sonodynamic therapy is the mitochondria-caspase pathway despite the participation of endoplasmic reticulum stress.

Wang H, Yang Y, Chen H, Dan J, Cheng J, Guo S, Sun X, Wang W, Ai Y, Li S, Li Z, Peng L, Tian Z, Yang L, Wu J, Zhong X, Zhou Q, Wang P, Zhang Z, Cao W, Tian Y.

Cell Physiol Biochem. 2014;33(6):1789-801. doi: 10.1159/000362958. Epub 2014 May 27.


Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway.

Wang HC, Hsieh SC, Yang JH, Lin SY, Sheen LY.

Nutr Cancer. 2012;64(5):770-80. doi: 10.1080/01635581.2012.676142. Epub 2012 Apr 20.


Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress.

Ip SW, Lan SH, Lu HF, Huang AC, Yang JS, Lin JP, Huang HY, Lien JC, Ho CC, Chiu CF, Wood W, Chung JG.

Hum Exp Toxicol. 2012 Jun;31(6):539-49. doi: 10.1177/0960327111417269. Epub 2011 Aug 22.


Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway.

Yen YP, Tsai KS, Chen YW, Huang CF, Yang RS, Liu SH.

Arch Toxicol. 2012 Jun;86(6):923-33. doi: 10.1007/s00204-012-0864-9. Epub 2012 May 24.


Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway.

Su J, Yan Y, Qu J, Xue X, Liu Z, Cai H.

Oncol Rep. 2017 Mar;37(3):1565-1572. doi: 10.3892/or.2017.5428. Epub 2017 Feb 7.


ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells.

Gu S, Chen C, Jiang X, Zhang Z.

Chem Biol Interact. 2016 Feb 5;245:100-9. doi: 10.1016/j.cbi.2016.01.005. Epub 2016 Jan 6.


Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways.

Lu TH, Tseng TJ, Su CC, Tang FC, Yen CC, Liu YY, Yang CY, Wu CC, Chen KL, Hung DZ, Chen YW.

Toxicol Lett. 2014 Jan 3;224(1):130-40. doi: 10.1016/j.toxlet.2013.10.013. Epub 2013 Oct 21.


Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model.

Ma YS, Weng SW, Lin MW, Lu CC, Chiang JH, Yang JS, Lai KC, Lin JP, Tang NY, Lin JG, Chung JG.

Food Chem Toxicol. 2012 May;50(5):1271-8. doi: 10.1016/j.fct.2012.01.033. Epub 2012 Feb 1.


Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms.

Jiang Y, Li Z, Liu Y, Liu X, Chang Q, Liao Y, Pan R.

J Ethnopharmacol. 2015 Jan 15;159:102-12. doi: 10.1016/j.jep.2014.10.062. Epub 2014 Nov 15.


Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways.

Huang SH, Wu LW, Huang AC, Yu CC, Lien JC, Huang YP, Yang JS, Yang JH, Hsiao YP, Wood WG, Yu CS, Chung JG.

J Agric Food Chem. 2012 Jan 18;60(2):665-75. doi: 10.1021/jf204193v. Epub 2012 Jan 6.


Hyperglycemia magnifies bupivacaine-induced cell apoptosis triggered by mitochondria dysfunction and endoplasmic reticulum stress.

Li L, Ye XP, Lu AZ, Zhou SQ, Liu H, Liu ZJ, Jiang S, Xu SY.

J Neurosci Res. 2013 Jun;91(6):786-98. doi: 10.1002/jnr.23216. Epub 2013 Mar 29.


The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway.

Lee JH, Li YC, Ip SW, Hsu SC, Chang NW, Tang NY, Yu CS, Chou ST, Lin SS, Lino CC, Yang JS, Chung JG.

Anticancer Res. 2008 May-Jun;28(3A):1701-11.

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