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Items: 1 to 20 of 120

1.

Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues.

Jedhe GS, Paul D, Gonnade RG, Santra MK, Hamel E, Nguyen TL, Sanjayan GJ.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4680-4. doi: 10.1016/j.bmcl.2013.06.004. Epub 2013 Jun 12.

2.
3.

Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity.

Kale SS, Jedhe GS, Meshram SN, Santra MK, Hamel E, Sanjayan GJ.

Bioorg Med Chem Lett. 2015 May 1;25(9):1982-5. doi: 10.1016/j.bmcl.2015.03.019. Epub 2015 Mar 14.

4.

Naphthalene combretastatin analogues: synthesis, cytotoxicity and antitubulin activity.

Medarde M, Maya AB, Pérez-Melero C.

J Enzyme Inhib Med Chem. 2004 Dec;19(6):521-40. Review.

PMID:
15662956
5.

Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.

Romagnoli R, Baraldi PG, Salvador MK, Preti D, Aghazadeh Tabrizi M, Brancale A, Fu XH, Li J, Zhang SZ, Hamel E, Bortolozzi R, Basso G, Viola G.

J Med Chem. 2012 Jan 12;55(1):475-88. doi: 10.1021/jm2013979. Epub 2011 Dec 21.

6.

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

Romagnoli R, Baraldi PG, Cruz-Lopez O, Lopez Cara C, Carrion MD, Brancale A, Hamel E, Chen L, Bortolozzi R, Basso G, Viola G.

J Med Chem. 2010 May 27;53(10):4248-58. doi: 10.1021/jm100245q.

7.

Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.

Ducki S, Rennison D, Woo M, Kendall A, Chabert JF, McGown AT, Lawrence NJ.

Bioorg Med Chem. 2009 Nov 15;17(22):7698-710. doi: 10.1016/j.bmc.2009.09.039. Epub 2009 Sep 25.

PMID:
19837593
8.

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.

dos Santos Edos A, Hamel E, Bai R, Burnett JC, Tozatti CS, Bogo D, Perdomo RT, Antunes AM, Marques MM, Matos Mde F, de Lima DP.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4669-73. doi: 10.1016/j.bmcl.2013.06.009. Epub 2013 Jun 12.

9.

Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.

Jalily PH, Hadfield JA, Hirst N, Rossington SB.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6731-4. doi: 10.1016/j.bmcl.2012.08.089. Epub 2012 Sep 7.

PMID:
23010271
10.

Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization.

Provot O, Hamze A, Peyrat JF, Brion JD, Alami M.

Anticancer Agents Med Chem. 2013 Dec;13(10):1614-35.

PMID:
24261611
11.

Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents.

Galli U, Travelli C, Aprile S, Arrigoni E, Torretta S, Grosa G, Massarotti A, Sorba G, Canonico PL, Genazzani AA, Tron GC.

J Med Chem. 2015 Feb 12;58(3):1345-57. doi: 10.1021/jm5016389. Epub 2015 Jan 27.

PMID:
25584687
12.

Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents.

Hu Y, Lu X, Chen K, Yan R, Li QS, Zhu HL.

Bioorg Med Chem. 2012 Jan 15;20(2):903-9. doi: 10.1016/j.bmc.2011.11.057. Epub 2011 Dec 3.

PMID:
22192936
13.

Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers.

Kamal A, Shaik B, Nayak VL, Nagaraju B, Kapure JS, Shaheer Malik M, Shaik TB, Prasad B.

Bioorg Med Chem. 2014 Oct 1;22(19):5155-67. doi: 10.1016/j.bmc.2014.08.008. Epub 2014 Aug 19.

PMID:
25192811
14.

Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents.

Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA.

Eur J Med Chem. 2015 Mar 6;92:212-20. doi: 10.1016/j.ejmech.2014.12.050. Epub 2014 Dec 29.

15.

Pyrazolone-fused combretastatins and their precursors: synthesis, cytotoxicity, antitubulin activity and molecular modeling studies.

Burja B, Cimbora-Zovko T, Tomić S, Jelusić T, Kocevar M, Polanc S, Osmak M.

Bioorg Med Chem. 2010 Apr 1;18(7):2375-87. doi: 10.1016/j.bmc.2010.03.006. Epub 2010 Mar 10.

PMID:
20338766
16.

Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.

Romagnoli R, Baraldi PG, Pavani MG, Tabrizi MA, Preti D, Fruttarolo F, Piccagli L, Jung MK, Hamel E, Borgatti M, Gambari R.

J Med Chem. 2006 Jun 29;49(13):3906-15.

PMID:
16789746
17.

Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors.

Kamal A, Srikanth PS, Vishnuvardhan MV, Kumar GB, Suresh Babu K, Hussaini SM, Kapure JS, Alarifi A.

Bioorg Chem. 2016 Apr;65:126-36. doi: 10.1016/j.bioorg.2016.02.007. Epub 2016 Feb 26.

PMID:
26943479
18.

Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents.

Sun B, Li L, Hu QW, Zheng HB, Tang H, Niu HM, Yuan HQ, Lou HX.

Eur J Med Chem. 2017 Mar 31;129:186-208. doi: 10.1016/j.ejmech.2017.02.021. Epub 2017 Feb 10.

PMID:
28222318
19.

Design, synthesis and biological studies of novel tubulin inhibitors.

Sun Y, Pandit B, Chettiar SN, Etter JP, Lewis A, Johnsamuel J, Li PK.

Bioorg Med Chem Lett. 2013 Aug 1;23(15):4465-8. doi: 10.1016/j.bmcl.2013.04.078. Epub 2013 May 7.

PMID:
23790539
20.

Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents.

An W, Wang W, Yu T, Zhang Y, Miao Z, Meng T, Shen J.

Eur J Med Chem. 2016 Apr 13;112:367-72. doi: 10.1016/j.ejmech.2016.02.004. Epub 2016 Feb 5.

PMID:
26927488

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