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Items: 1 to 20 of 149

1.

Molecular basis for the regulation of hypoxia-inducible factor-1α levels by 2-deoxy-D-ribose.

Ikeda R, Tabata S, Tajitsu Y, Nishizawa Y, Minami K, Furukawa T, Yamamoto M, Shinsato Y, Akiyama S, Yamada K, Takeda Y.

Oncol Rep. 2013 Sep;30(3):1444-8. doi: 10.3892/or.2013.2572. Epub 2013 Jun 27.

PMID:
23807085
2.
3.

Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-ribose.

Ikeda R, Furukawa T, Kitazono M, Ishitsuka K, Okumura H, Tani A, Sumizawa T, Haraguchi M, Komatsu M, Uchimiya H, Ren XQ, Motoya T, Yamada K, Akiyama S.

Biochem Biophys Res Commun. 2002 Mar 8;291(4):806-12.

PMID:
11866437
4.

Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3.

Ikeda R, Tajitsu Y, Iwashita K, Che XF, Yoshida K, Ushiyama M, Furukawa T, Komatsu M, Yamaguchi T, Shibayama Y, Yamamoto M, Zhao HY, Arima J, Takeda Y, Akiyama S, Yamada K.

Biochem Biophys Res Commun. 2008 May 30;370(2):220-4. doi: 10.1016/j.bbrc.2008.03.067. Epub 2008 Mar 24.

PMID:
18359286
5.

Gambogic acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1α pathway.

Lu N, Hui H, Yang H, Zhao K, Chen Y, You QD, Guo QL.

Eur J Pharm Sci. 2013 May 13;49(2):220-6. doi: 10.1016/j.ejps.2013.02.018. Epub 2013 Mar 15.

PMID:
23501055
6.

Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.

Hou P, Kuo CY, Cheng CT, Liou JP, Ann DK, Chen Q.

PLoS One. 2014 Nov 24;9(11):e113865. doi: 10.1371/journal.pone.0113865. eCollection 2014.

8.

Increased hypoxia-inducible factor-1α in striated muscle of tumor-bearing mice.

Devine RD, Bicer S, Reiser PJ, Wold LE.

Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1154-H1162. doi: 10.1152/ajpheart.00090.2016. Epub 2017 Mar 24.

PMID:
28341633
9.

Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells.

Jung DB, Lee HJ, Jeong SJ, Lee HJ, Lee EO, Kim YC, Ahn KS, Chen CY, Kim SH.

Biol Pharm Bull. 2011;34(6):850-5.

10.

2-Deoxy-D-ribose inhibits hypoxia-induced apoptosis by suppressing the phosphorylation of p38 MAPK.

Ikeda R, Che XF, Ushiyama M, Yamaguchi T, Okumura H, Nakajima Y, Takeda Y, Shibayama Y, Furukawa T, Yamamoto M, Haraguchi M, Sumizawa T, Yamada K, Akiyama S.

Biochem Biophys Res Commun. 2006 Mar 31;342(1):280-5. Epub 2006 Feb 6.

PMID:
16480951
11.

Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.

Lee HY, Lee T, Lee N, Yang EG, Lee C, Lee J, Moon EY, Ha J, Park H.

Carcinogenesis. 2011 May;32(5):703-12. doi: 10.1093/carcin/bgr034. Epub 2011 Feb 18.

PMID:
21335603
12.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

Foxler DE, Bridge KS, James V, Webb TM, Mee M, Wong SC, Feng Y, Constantin-Teodosiu D, Petursdottir TE, Bjornsson J, Ingvarsson S, Ratcliffe PJ, Longmore GD, Sharp TV.

Nat Cell Biol. 2012 Jan 29;14(2):201-8. doi: 10.1038/ncb2424.

PMID:
22286099
13.

TNF stimulation induces VHL overexpression and impairs angiogenic potential in skeletal muscle myocytes.

Basic VT, Jacobsen A, Sirsjö A, Abdel-Halim SM.

Int J Mol Med. 2014 Jul;34(1):228-36. doi: 10.3892/ijmm.2014.1776. Epub 2014 May 9.

PMID:
24820910
16.

Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity.

Park MH, Bae SS, Choi KY, Min do S.

Exp Mol Med. 2015 Nov 27;47:e196. doi: 10.1038/emm.2015.87.

17.

Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel-Lindau-dependent pathway.

Li CH, Liao PL, Yang YT, Huang SH, Lin CH, Cheng YW, Kang JJ.

Arch Toxicol. 2014 Mar;88(3):659-71. doi: 10.1007/s00204-013-1175-5. Epub 2013 Dec 1.

PMID:
24292262
18.

Runx2 protein stabilizes hypoxia-inducible factor-1α through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes.

Lee SH, Che X, Jeong JH, Choi JY, Lee YJ, Lee YH, Bae SC, Lee YM.

J Biol Chem. 2012 Apr 27;287(18):14760-71. doi: 10.1074/jbc.M112.340232. Epub 2012 Feb 20.

19.

Increased activation of the hypoxia-inducible factor pathway in varicose veins.

Lim CS, Kiriakidis S, Paleolog EM, Davies AH.

J Vasc Surg. 2012 May;55(5):1427-39. doi: 10.1016/j.jvs.2011.10.111. Epub 2012 Jan 24.

20.

Down-regulation of HIF-1alpha by oncolytic reovirus infection independently of VHL and p53.

Cho IR, Koh SS, Min HJ, Park EH, Ratakorn S, Jhun BH, Jeong SH, Yoo YH, Youn HD, Johnston RN, Chung YH.

Cancer Gene Ther. 2010 May;17(5):365-72. doi: 10.1038/cgt.2009.84. Epub 2010 Jan 15.

PMID:
20075985

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