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Items: 1 to 20 of 90

1.

Screening-based discovery of the first novel ATP competitive inhibitors of the Staphylococcus aureus essential enzyme UMP kinase.

Doig P, Gorseth E, Nash T, Patten A, Gao N, Blackett C.

Biochem Biophys Res Commun. 2013 Jul 19;437(1):162-7. doi: 10.1016/j.bbrc.2013.06.060. Epub 2013 Jun 24.

PMID:
23806686
2.

Discovery of a compound which acts as a bacterial UMP kinase PyrH inhibitor.

Yoshida T, Nasu H, Namba E, Ubukata O, Yamashita M.

FEMS Microbiol Lett. 2012 May;330(2):121-6. doi: 10.1111/j.1574-6968.2012.02546.x. Epub 2012 Apr 2.

3.

A bioluminescent method for measuring thymidylate kinase activity suitable for high-throughput screening of inhibitor.

Hu CM, Chang ZF.

Anal Biochem. 2010 Mar 15;398(2):269-71. doi: 10.1016/j.ab.2009.12.001. Epub 2009 Dec 6.

PMID:
19995545
4.

A high-throughput, nonisotopic, competitive binding assay for kinases using nonselective inhibitor probes (ED-NSIP).

Vainshtein I, Silveria S, Kaul P, Rouhani R, Eglen RM, Wang J.

J Biomol Screen. 2002 Dec;7(6):507-14.

PMID:
14599348
5.

Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK).

Martínez-Botella G, Loch JT, Green OM, Kawatkar SP, Olivier NB, Boriack-Sjodin PA, Keating TA.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):169-73. doi: 10.1016/j.bmcl.2012.10.128. Epub 2012 Nov 5.

PMID:
23206863
6.

6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase.

Škedelj V, Arsovska E, Tomašić T, Kroflič A, Hodnik V, Hrast M, Bešter-Rogač M, Anderluh G, Gobec S, Bostock J, Chopra I, O'Neill AJ, Randall C, Zega A.

PLoS One. 2012;7(8):e39922. doi: 10.1371/journal.pone.0039922. Epub 2012 Aug 2.

7.

Streptococcus pneumononiae gyrase ATPase: development and validation of an assay for inhibitor discovery and characterization.

Miller JR, Herberg JT, Tomilo M, McCroskey MC, Feilmeier BJ.

Anal Biochem. 2007 Jun 1;365(1):132-43. Epub 2007 Feb 27.

PMID:
17395144
8.

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III.

Ali A, Aster SD, Graham DW, Patel GF, Taylor GE, Tolman RL, Painter RE, Silver LL, Young K, Ellsworth K, Geissler W, Harris GS.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2185-8.

PMID:
11514166
9.

Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC.

Rose Y, Ciblat S, Reddy R, Belley AC, Dietrich E, Lehoux D, McKay GA, Poirier H, Far AR, Delorme D.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):891-6. Epub 2005 Nov 17.

PMID:
16298129
10.

In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound.

Keating TA, Newman JV, Olivier NB, Otterson LG, Andrews B, Boriack-Sjodin PA, Breen JN, Doig P, Dumas J, Gangl E, Green OM, Guler SY, Hentemann MF, Joseph-McCarthy D, Kawatkar S, Kutschke A, Loch JT, McKenzie AR, Pradeepan S, Prasad S, Martínez-Botella G.

ACS Chem Biol. 2012 Nov 16;7(11):1866-72. doi: 10.1021/cb300316n. Epub 2012 Aug 28.

PMID:
22908966
11.

Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).

Martínez-Botella G, Breen JN, Duffy JE, Dumas J, Geng B, Gowers IK, Green OM, Guler S, Hentemann MF, Hernandez-Juan FA, Joseph-McCarthy D, Kawatkar S, Larsen NA, Lazari O, Loch JT, Macritchie JA, McKenzie AR, Newman JV, Olivier NB, Otterson LG, Owens AP, Read J, Sheppard DW, Keating TA.

J Med Chem. 2012 Nov 26;55(22):10010-21. doi: 10.1021/jm3011806. Epub 2012 Oct 24.

PMID:
23043329
12.

UMP kinase from Streptococcus pneumoniae: evidence for co-operative ATP binding and allosteric regulation.

Fassy F, Krebs O, Lowinski M, Ferrari P, Winter J, Collard-Dutilleul V, Salahbey Hocini K.

Biochem J. 2004 Dec 15;384(Pt 3):619-27.

13.

Regulatory mechanisms differ in UMP kinases from gram-negative and gram-positive bacteria.

Evrin C, Straut M, Slavova-Azmanova N, Bucurenci N, Onu A, Assairi L, Ionescu M, Palibroda N, Bârzu O, Gilles AM.

J Biol Chem. 2007 Mar 9;282(10):7242-53. Epub 2007 Jan 8.

14.

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase.

Jarvest RL, Erskine SG, Forrest AK, Fosberry AP, Hibbs MJ, Jones JJ, O'Hanlon PJ, Sheppard RJ, Worby A.

Bioorg Med Chem Lett. 2005 May 2;15(9):2305-9.

PMID:
15837314
15.

Structural and functional investigations of Ureaplasma parvum UMP kinase--a potential antibacterial drug target.

Egeblad-Welin L, Welin M, Wang L, Eriksson S.

FEBS J. 2007 Dec;274(24):6403-14. Epub 2007 Nov 15.

16.

Cloning, expression, purification and characterization of UMP kinase from Staphylococcus aureus.

Hari Prasad O, Nanda Kumar Y, Reddy OV, Chaudhary A, Sarma PV.

Protein J. 2012 Apr;31(4):345-52. doi: 10.1007/s10930-012-9410-0.

PMID:
22528139
17.

Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.

Choudhry AE, Mandichak TL, Broskey JP, Egolf RW, Kinsland C, Begley TP, Seefeld MA, Ku TW, Brown JR, Zalacain M, Ratnam K.

Antimicrob Agents Chemother. 2003 Jun;47(6):2051-5.

18.

Identification of novel antimycobacterial chemical agents through the in silico multi-conformational structure-based drug screening of a large-scale chemical library.

Koseki Y, Kinjo T, Kobayashi M, Aoki S.

Eur J Med Chem. 2013 Feb;60:333-9. doi: 10.1016/j.ejmech.2012.12.012. Epub 2012 Dec 20.

PMID:
23314046
19.

Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJ, De Los Angeles J, Fishwick CW, Chopra I.

J Antimicrob Chemother. 2010 Dec;65(12):2566-73. doi: 10.1093/jac/dkq349. Epub 2010 Sep 22.

PMID:
20861142
20.

Efficient heterologous expression and one-step purification of fully active c-terminal histidine-tagged uridine monophosphate kinase from Mycobacterium tuberculosis.

Penpassakarn P, Chaiyen P, Palittapongarnpim P.

Southeast Asian J Trop Med Public Health. 2011 Nov;42(6):1452-9.

PMID:
22299415

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