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Items: 1 to 20 of 99

1.

The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.

Liu Z, Chen S, Boyle S, Zhu Y, Zhang A, Piwnica-Worms DR, Ilagan MX, Kopan R.

Dev Cell. 2013 Jun 24;25(6):585-98. doi: 10.1016/j.devcel.2013.05.022.

2.

The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.

Surendran K, Boyle S, Barak H, Kim M, Stomberski C, McCright B, Kopan R.

Dev Biol. 2010 Jan 15;337(2):386-95. doi: 10.1016/j.ydbio.2009.11.017. Epub 2009 Nov 13.

3.

Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.

Gordon WR, Vardar-Ulu D, L'Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, Blacklow SC.

PLoS One. 2009 Aug 24;4(8):e6613. doi: 10.1371/journal.pone.0006613.

4.

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R.

Development. 2007 Feb;134(4):801-11. Epub 2007 Jan 17.

5.

Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development.

Sweetwyne MT, Gruenwald A, Niranjan T, Nishinakamura R, Strobl LJ, Susztak K.

Diabetes. 2015 Dec;64(12):4099-111. doi: 10.2337/db15-0260. Epub 2015 Aug 20.

6.

Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice.

Geisler F, Nagl F, Mazur PK, Lee M, Zimber-Strobl U, Strobl LJ, Radtke F, Schmid RM, Siveke JT.

Hepatology. 2008 Aug;48(2):607-16. doi: 10.1002/hep.22381.

PMID:
18666240
7.

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.

Liu Z, Brunskill E, Varnum-Finney B, Zhang C, Zhang A, Jay PY, Bernstein I, Morimoto M, Kopan R.

Development. 2015 Jul 15;142(14):2452-63. doi: 10.1242/dev.125492. Epub 2015 Jun 10.

8.

A role for notch signaling in human corneal epithelial cell differentiation and proliferation.

Ma A, Boulton M, Zhao B, Connon C, Cai J, Albon J.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3576-85.

PMID:
17652726
9.

Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.

Boyle SC, Liu Z, Kopan R.

Development. 2014 Jan;141(2):346-54. doi: 10.1242/dev.100271. Epub 2013 Dec 18.

10.

Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins.

Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J.

J Biol Chem. 2012 Jun 8;287(24):20356-68. doi: 10.1074/jbc.M112.349738. Epub 2012 Apr 13.

11.

Renal involvement and the role of Notch signalling in Alagille syndrome.

Kamath BM, Spinner NB, Rosenblum ND.

Nat Rev Nephrol. 2013 Jul;9(7):409-18. doi: 10.1038/nrneph.2013.102. Epub 2013 Jun 11. Review.

PMID:
23752887
12.

Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy.

Kopan R, Chen S, Liu Z.

Pediatr Nephrol. 2014 Apr;29(4):651-7. doi: 10.1007/s00467-013-2661-y. Epub 2013 Nov 24. Review.

13.

Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.

Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S.

Pigment Cell Melanoma Res. 2008 Feb;21(1):70-8. doi: 10.1111/j.1755-148X.2007.00423.x.

PMID:
18353145
14.

Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.

Habets RA, Groot AJ, Yahyanejad S, Tiyanont K, Blacklow SC, Vooijs M.

J Biol Chem. 2015 Jun 5;290(23):14705-16. doi: 10.1074/jbc.M115.643676. Epub 2015 Apr 27.

15.

Functional conservation of Notch1 and Notch2 intracellular domains.

Kraman M, McCright B.

FASEB J. 2005 Aug;19(10):1311-3. Epub 2005 May 16.

PMID:
15897231
16.

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, Weinmaster G.

Nat Cell Biol. 2000 Aug;2(8):515-20.

PMID:
10934472
17.

Characterization of CSL (CBF-1, Su(H), Lag-1) mutants reveals differences in signaling mediated by Notch1 and Notch2.

Yuan Z, Friedmann DR, VanderWielen BD, Collins KJ, Kovall RA.

J Biol Chem. 2012 Oct 12;287(42):34904-16. doi: 10.1074/jbc.M112.403287. Epub 2012 Aug 22.

18.

Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.

McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, Weinmaster G, Jiang R, Gridley T.

Development. 2001 Feb;128(4):491-502.

19.

A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency.

McCright B, Lozier J, Gridley T.

Development. 2002 Feb;129(4):1075-82.

20.

The role of Notch receptor expression in bile duct development and disease.

Flynn DM, Nijjar S, Hubscher SG, de Goyet Jde V, Kelly DA, Strain AJ, Crosby HA.

J Pathol. 2004 Sep;204(1):55-64.

PMID:
15307138

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