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Items: 1 to 20 of 129

1.

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance.

Shi K, Caldwell SJ, Fong DH, Berghuis AM.

Front Cell Infect Microbiol. 2013 Jun 25;3:22. doi: 10.3389/fcimb.2013.00022. eCollection 2013. Review.

2.

Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.

Stogios PJ, Spanogiannopoulos P, Evdokimova E, Egorova O, Shakya T, Todorovic N, Capretta A, Wright GD, Savchenko A.

Biochem J. 2013 Sep 1;454(2):191-200. doi: 10.1042/BJ20130317.

3.

Aminoglycoside phosphotransferases: proteins, structure, and mechanism.

Wright GD, Thompson PR.

Front Biosci. 1999 Jan 1;4:D9-21. Review.

PMID:
9872733
4.

Molecular targets for design of novel inhibitors to circumvent aminoglycoside resistance.

Jana S, Deb JK.

Curr Drug Targets. 2005 May;6(3):353-61. Review.

PMID:
15857293
5.

Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics.

Fong DH, Berghuis AM.

Antimicrob Agents Chemother. 2009 Jul;53(7):3049-55. doi: 10.1128/AAC.00062-09. Epub 2009 May 11.

6.

Aminoglycoside antibiotic phosphotransferases are also serine protein kinases.

Daigle DM, McKay GA, Thompson PR, Wright GD.

Chem Biol. 1999 Jan;6(1):11-8.

7.

Aminoglycoside antibiotic resistance by enzymatic deactivation.

Smith CA, Baker EN.

Curr Drug Targets Infect Disord. 2002 Jun;2(2):143-60. Review.

PMID:
12462145
8.

Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections.

Labby KJ, Garneau-Tsodikova S.

Future Med Chem. 2013 Jul;5(11):1285-309. doi: 10.4155/fmc.13.80. Review.

9.

The COOH terminus of aminoglycoside phosphotransferase (3')-IIIa is critical for antibiotic recognition and resistance.

Thompson PR, Schwartzenhauer J, Hughes DW, Berghuis AM, Wright GD.

J Biol Chem. 1999 Oct 22;274(43):30697-706.

10.

Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT(2″)-Ia.

Cox G, Stogios PJ, Savchenko A, Wright GD.

MBio. 2015 Jan 6;6(1). pii: e02180-14. doi: 10.1128/mBio.02180-14.

11.
12.

Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor.

Fong DH, Xiong B, Hwang J, Berghuis AM.

PLoS One. 2011 May 9;6(5):e19589. doi: 10.1371/journal.pone.0019589.

13.

Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes.

Boehr DD, Draker KA, Koteva K, Bains M, Hancock RE, Wright GD.

Chem Biol. 2003 Feb;10(2):189-96.

14.

Molecular identification of aminoglycoside-modifying enzymes in clinical isolates of Escherichia coli resistant to amoxicillin/clavulanic acid isolated in Spain.

Fernández-Martínez M, Miró E, Ortega A, Bou G, González-López JJ, Oliver A, Pascual A, Cercenado E, Oteo J, Martínez-Martínez L, Navarro F; Spanish Network for the Research in Infectious Diseases (REIPI).

Int J Antimicrob Agents. 2015 Aug;46(2):157-63. doi: 10.1016/j.ijantimicag.2015.03.008. Epub 2015 Apr 29.

PMID:
26022930
15.

Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition.

Azucena E, Mobashery S.

Drug Resist Updat. 2001 Apr;4(2):106-17. Review.

PMID:
11512519
16.

Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors.

Daigle DM, McKay GA, Wright GD.

J Biol Chem. 1997 Oct 3;272(40):24755-8.

17.

Nucleotide selectivity of antibiotic kinases.

Shakya T, Wright GD.

Antimicrob Agents Chemother. 2010 May;54(5):1909-13. doi: 10.1128/AAC.01570-09. Epub 2010 Mar 15.

18.

[Molecular identification of aminoglycoside-modifying enzymes among strains of Enterococcus spp. isolated in hospitals of the VIII Region of Chile].

Sepúlveda MA, Bello HT, Domínguez MY, Mella SM, Zemelman RZ, González GR.

Rev Med Chil. 2007 May;135(5):566-72. Epub 2007 Jul 9. Spanish.

19.

Developing a snapshot of the ATP binding domain(s) of aminoglycoside phosphotransferases.

Perlin MH, Brown SA, Dholakia JN.

Front Biosci. 1999 Jan 1;4:D63-71. Review.

PMID:
9872732
20.

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