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Items: 1 to 20 of 206

1.

RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.

Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T.

Hum Mol Genet. 2013 Nov 15;22(22):4474-84. doi: 10.1093/hmg/ddt296. Epub 2013 Jun 25.

PMID:
23804749
2.

Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.

Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T.

J Biol Chem. 2016 Nov 4;291(45):23464-23476. Epub 2016 Sep 15.

PMID:
27634045
3.

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.

Miguel L, Fr├ębourg T, Campion D, Lecourtois M.

Neurobiol Dis. 2011 Feb;41(2):398-406. doi: 10.1016/j.nbd.2010.10.007. Epub 2010 Oct 14.

PMID:
20951205
4.

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders.

Janssens J, Van Broeckhoven C.

Hum Mol Genet. 2013 Oct 15;22(R1):R77-87. doi: 10.1093/hmg/ddt349. Epub 2013 Jul 29. Review.

5.

A Drosophila model for TDP-43 proteinopathy.

Li Y, Ray P, Rao EJ, Shi C, Guo W, Chen X, Woodruff EA 3rd, Fushimi K, Wu JY.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3169-74. doi: 10.1073/pnas.0913602107. Epub 2010 Jan 26.

6.

Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis.

Estes PS, Daniel SG, McCallum AP, Boehringer AV, Sukhina AS, Zwick RA, Zarnescu DC.

Dis Model Mech. 2013 May;6(3):721-33. doi: 10.1242/dmm.010710. Epub 2013 Feb 1.

7.
8.

PABPN1 suppresses TDP-43 toxicity in ALS disease models.

Chou CC, Alexeeva OM, Yamada S, Pribadi A, Zhang Y, Mo B, Williams KR, Zarnescu DC, Rossoll W.

Hum Mol Genet. 2015 Sep 15;24(18):5154-73. doi: 10.1093/hmg/ddv238. Epub 2015 Jun 30.

9.

Disease animal models of TDP-43 proteinopathy and their pre-clinical applications.

Liu YC, Chiang PM, Tsai KJ.

Int J Mol Sci. 2013 Oct 9;14(10):20079-111. doi: 10.3390/ijms141020079. Review.

10.

Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats.

Huang C, Tong J, Bi F, Zhou H, Xia XG.

J Clin Invest. 2012 Jan;122(1):107-18. doi: 10.1172/JCI59130. Epub 2011 Dec 12.

11.

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.

Wang G, Yang H, Yan S, Wang CE, Liu X, Zhao B, Ouyang Z, Yin P, Liu Z, Zhao Y, Liu T, Fan N, Guo L, Li S, Li XJ, Lai L.

Mol Neurodegener. 2015 Sep 3;10:42. doi: 10.1186/s13024-015-0036-5.

12.

Expression of human FUS protein in Drosophila leads to progressive neurodegeneration.

Chen Y, Yang M, Deng J, Chen X, Ye Y, Zhu L, Liu J, Ye H, Shen Y, Li Y, Rao EJ, Fushimi K, Zhou X, Bigio EH, Mesulam M, Xu Q, Wu JY.

Protein Cell. 2011 Jun;2(6):477-86. doi: 10.1007/s13238-011-1065-7. Epub 2011 Jul 12.

13.

TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases.

Warraich ST, Yang S, Nicholson GA, Blair IP.

Int J Biochem Cell Biol. 2010 Oct;42(10):1606-9. doi: 10.1016/j.biocel.2010.06.016. Epub 2010 Jun 25. Review.

PMID:
20601083
14.

Rapamycin alleviates pathogenesis of a new Drosophila model of ALS-TDP.

Cheng CW, Lin MJ, Shen CK.

J Neurogenet. 2015;29(2-3):59-68. doi: 10.3109/01677063.2015.1077832. Epub 2015 Sep 25.

PMID:
26219309
15.

Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes.

Diaper DC, Adachi Y, Sutcliffe B, Humphrey DM, Elliott CJ, Stepto A, Ludlow ZN, Vanden Broeck L, Callaerts P, Dermaut B, Al-Chalabi A, Shaw CE, Robinson IM, Hirth F.

Hum Mol Genet. 2013 Apr 15;22(8):1539-57. doi: 10.1093/hmg/ddt005. Epub 2013 Jan 10.

16.

[Clinical and pathological spectrum of TDP-43 associated ALS].

Onodera O, Yokoseki A, Tan CF, Ishihara T, Nishiira Y, Toyoshima Y, Kakita A, Nishizawa M, Takahashi H.

Rinsho Shinkeigaku. 2010 Nov;50(11):940-2. Review. Japanese.

PMID:
21921519
17.

TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?

Vanden Broeck L, Callaerts P, Dermaut B.

Trends Mol Med. 2014 Feb;20(2):66-71. doi: 10.1016/j.molmed.2013.11.003. Epub 2013 Dec 16.

PMID:
24355761
18.

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS.

Krug L, Chatterjee N, Borges-Monroy R, Hearn S, Liao WW, Morrill K, Prazak L, Rozhkov N, Theodorou D, Hammell M, Dubnau J.

PLoS Genet. 2017 Mar 16;13(3):e1006635. doi: 10.1371/journal.pgen.1006635. eCollection 2017 Mar.

19.

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.

Scotter EL, Chen HJ, Shaw CE.

Neurotherapeutics. 2015 Apr;12(2):352-63. doi: 10.1007/s13311-015-0338-x. Review. Erratum in: Neurotherapeutics. 2015 Apr;12(2):515-8.

20.

Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD.

Diaper DC, Adachi Y, Lazarou L, Greenstein M, Simoes FA, Di Domenico A, Solomon DA, Lowe S, Alsubaie R, Cheng D, Buckley S, Humphrey DM, Shaw CE, Hirth F.

Hum Mol Genet. 2013 Oct 1;22(19):3883-93. doi: 10.1093/hmg/ddt243. Epub 2013 May 31.

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