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Items: 1 to 20 of 105

1.

Effect of cell culture medium components on color of formulated monoclonal antibody drug substance.

Vijayasankaran N, Varma S, Yang Y, Mun M, Arevalo S, Gawlitzek M, Swartz T, Lim A, Li F, Zhang B, Meier S, Kiss R.

Biotechnol Prog. 2013 Sep-Oct;29(5):1270-7. doi: 10.1002/btpr.1772. Epub 2013 Jun 27.

PMID:
23804462
2.

Red colored IgG4 caused by vitamin B12 from cell culture media combined with disulfide reduction at harvest.

Derfus GE, Dizon-Maspat J, Broddrick JT, Velayo AC, Toschi JD, Santuray RT, Hsu SK, Winter CM, Krishnan R, Amanullah A.

MAbs. 2014 May-Jun;6(3):679-88. doi: 10.4161/mabs.28257. Epub 2014 Feb 19.

3.

Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media.

Luo J, Zhang J, Ren D, Tsai WL, Li F, Amanullah A, Hudson T.

Biotechnol Bioeng. 2012 Sep;109(9):2306-15. doi: 10.1002/bit.24510. Epub 2012 Apr 11.

PMID:
22473810
4.

Cell culture media impact on drug product solution stability.

Purdie JL, Kowle RL, Langland AL, Patel CN, Ouyang A, Olson DJ.

Biotechnol Prog. 2016 Jul 8;32(4):998-1008. doi: 10.1002/btpr.2289. Epub 2016 May 13.

PMID:
27111574
5.

Effect of ambient light on monoclonal antibody product quality during small-scale mammalian cell culture process in clear glass bioreactors.

Mallaney M, Wang SH, Sreedhara A.

Biotechnol Prog. 2014 May-Jun;30(3):562-70. doi: 10.1002/btpr.1920. Epub 2014 May 9.

PMID:
24777986
6.

Culture temperature modulates monoclonal antibody charge variation distribution in Chinese hamster ovary cell cultures.

Zhang X, Sun YT, Tang H, Fan L, Hu D, Liu J, Liu X, Tan WS.

Biotechnol Lett. 2015 Nov;37(11):2151-7. doi: 10.1007/s10529-015-1904-3. Epub 2015 Jul 7.

PMID:
26149578
7.

Modulation of mAb quality attributes using microliter scale fed-batch cultures.

Rouiller Y, Périlleux A, Vesin MN, Stettler M, Jordan M, Broly H.

Biotechnol Prog. 2014 May-Jun;30(3):571-83. doi: 10.1002/btpr.1921. Epub 2014 May 10.

PMID:
24777991
8.

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases.

Zhou M, Crawford Y, Ng D, Tung J, Pynn AF, Meier A, Yuk IH, Vijayasankaran N, Leach K, Joly J, Snedecor B, Shen A.

J Biotechnol. 2011 Apr 20;153(1-2):27-34. doi: 10.1016/j.jbiotec.2011.03.003. Epub 2011 Mar 30.

PMID:
21392546
9.

Hydroxocobalamin association during cell culture results in pink therapeutic proteins.

Prentice KM, Gillespie R, Lewis N, Fujimori K, McCoy R, Bach J, Connell-Crowley L, Eakin CM.

MAbs. 2013 Nov-Dec;5(6):974-81. doi: 10.4161/mabs.25921. Epub 2013 Jul 26.

10.

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism.

Ma N, Ellet J, Okediadi C, Hermes P, McCormick E, Casnocha S.

Biotechnol Prog. 2009 Sep-Oct;25(5):1353-63. doi: 10.1002/btpr.238.

PMID:
19637321
11.
12.

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose.

Gramer MJ, Eckblad JJ, Donahue R, Brown J, Shultz C, Vickerman K, Priem P, van den Bremer ET, Gerritsen J, van Berkel PH.

Biotechnol Bioeng. 2011 Jul;108(7):1591-602. doi: 10.1002/bit.23075. Epub 2011 Feb 18.

PMID:
21328321
13.
14.

Effects of cell culture conditions on antibody N-linked glycosylation--what affects high mannose 5 glycoform.

Pacis E, Yu M, Autsen J, Bayer R, Li F.

Biotechnol Bioeng. 2011 Oct;108(10):2348-58. doi: 10.1002/bit.23200. Epub 2011 May 24.

PMID:
21557201
15.

Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture.

Chong WP, Goh LT, Reddy SG, Yusufi FN, Lee DY, Wong NS, Heng CK, Yap MG, Ho YS.

Rapid Commun Mass Spectrom. 2009 Dec;23(23):3763-71. doi: 10.1002/rcm.4328.

PMID:
19902412
16.

Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability.

Chung WK, Russell B, Yang Y, Handlogten M, Hudak S, Cao M, Wang J, Robbins D, Ahuja S, Zhu M.

Biotechnol Bioeng. 2017 Jun;114(6):1264-1274. doi: 10.1002/bit.26265. Epub 2017 Mar 6.

17.

Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality.

Yang WC, Lu J, Kwiatkowski C, Yuan H, Kshirsagar R, Ryll T, Huang YM.

Biotechnol Prog. 2014 May-Jun;30(3):616-25. doi: 10.1002/btpr.1884. Epub 2014 Mar 3.

PMID:
24574326
18.

Elucidating the effects of pH shift on IgG1 monoclonal antibody acidic charge variant levels in Chinese hamster ovary cell cultures.

Xie P, Niu H, Chen X, Zhang X, Miao S, Deng X, Liu X, Tan WS, Zhou Y, Fan L.

Appl Microbiol Biotechnol. 2016 Dec;100(24):10343-10353. Epub 2016 Aug 2.

PMID:
27484582
19.

[Effect of vitamins B and C on the intestinal motor activity of rabbits in long-term experiments].

Wawrzeńska M, Nagórna-Stasiak B.

Pol Arch Weter. 1979;22(2):197-204. Polish.

PMID:
555511
20.

Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid.

Mun M, Khoo S, Do Minh A, Dvornicky J, Trexler-Schmidt M, Kao YH, Laird MW.

Biotechnol Bioeng. 2015 Apr;112(4):734-42. doi: 10.1002/bit.25495. Epub 2014 Dec 23.

PMID:
25384896

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