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Items: 1 to 20 of 102

1.

The ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loading.

Riera A, Fernández-Cid A, Speck C.

Cell Cycle. 2013 Jul 15;12(14):2155-6. No abstract available.

2.

Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.

Randell JC, Bowers JL, Rodríguez HK, Bell SP.

Mol Cell. 2006 Jan 6;21(1):29-39.

3.

The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level.

Duzdevich D, Warner MD, Ticau S, Ivica NA, Bell SP, Greene EC.

Mol Cell. 2015 May 7;58(3):483-94. doi: 10.1016/j.molcel.2015.03.017. Epub 2015 Apr 23.

4.

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.

Evrin C, Fernández-Cid A, Riera A, Zech J, Clarke P, Herrera MC, Tognetti S, Lurz R, Speck C.

Nucleic Acids Res. 2014 Feb;42(4):2257-69. doi: 10.1093/nar/gkt1148. Epub 2013 Nov 14.

5.

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome.

Kuo AJ, Song J, Cheung P, Ishibe-Murakami S, Yamazoe S, Chen JK, Patel DJ, Gozani O.

Nature. 2012 Mar 7;484(7392):115-9. doi: 10.1038/nature10956.

6.

Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.

Chen S, de Vries MA, Bell SP.

Genes Dev. 2007 Nov 15;21(22):2897-907.

7.

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA.

Samel SA, Fernández-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C.

Genes Dev. 2014 Aug 1;28(15):1653-66. doi: 10.1101/gad.242404.114.

8.

Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis.

de Munnik SA, Bicknell LS, Aftimos S, Al-Aama JY, van Bever Y, Bober MB, Clayton-Smith J, Edrees AY, Feingold M, Fryer A, van Hagen JM, Hennekam RC, Jansweijer MC, Johnson D, Kant SG, Opitz JM, Ramadevi AR, Reardon W, Ross A, Sarda P, Schrander-Stumpel CT, Schoots J, Temple IK, Terhal PA, Toutain A, Wise CA, Wright M, Skidmore DL, Samuels ME, Hoefsloot LH, Knoers NV, Brunner HG, Jackson AP, Bongers EM.

Eur J Hum Genet. 2012 Jun;20(6):598-606. doi: 10.1038/ejhg.2011.269. Epub 2012 Feb 15.

9.

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.

Bruck I, Kaplan DL.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11223-8. doi: 10.1073/pnas.1509608112. Epub 2015 Aug 24.

10.

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S, Evrin C, Winkler C, Gardenal E, Uhle S, Speck C.

Mol Cell. 2013 May 23;50(4):577-88. doi: 10.1016/j.molcel.2013.03.026. Epub 2013 Apr 18.

11.

CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6.

Chen S, Bell SP.

Genes Dev. 2011 Feb 15;25(4):363-72. doi: 10.1101/gad.2011511. Epub 2011 Feb 2.

12.

Mutations in the pre-replication complex cause Meier-Gorlin syndrome.

Bicknell LS, Bongers EM, Leitch A, Brown S, Schoots J, Harley ME, Aftimos S, Al-Aama JY, Bober M, Brown PA, van Bokhoven H, Dean J, Edrees AY, Feingold M, Fryer A, Hoefsloot LH, Kau N, Knoers NV, Mackenzie J, Opitz JM, Sarda P, Ross A, Temple IK, Toutain A, Wise CA, Wright M, Jackson AP.

Nat Genet. 2011 Feb 27;43(4):356-9. doi: 10.1038/ng.775.

13.

Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading.

Ticau S, Friedman LJ, Ivica NA, Gelles J, Bell SP.

Cell. 2015 Apr 23;161(3):513-25. doi: 10.1016/j.cell.2015.03.012. Epub 2015 Apr 16.

14.

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

Evrin C, Fernández-Cid A, Zech J, Herrera MC, Riera A, Clarke P, Brill S, Lurz R, Speck C.

Nucleic Acids Res. 2013 Mar 1;41(5):3162-72. doi: 10.1093/nar/gkt043. Epub 2013 Feb 1.

15.

The replication initiation protein Sld2 regulates helicase assembly.

Bruck I, Kaplan DL.

J Biol Chem. 2014 Jan 24;289(4):1948-59. doi: 10.1074/jbc.M113.532085. Epub 2013 Dec 4.

16.

Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing.

Chistol G, Walter JC.

Cell. 2015 Apr 23;161(3):429-30. doi: 10.1016/j.cell.2015.04.006.

17.

Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases.

Takara TJ, Bell SP.

EMBO J. 2011 Nov 1;30(24):4885-96. doi: 10.1038/emboj.2011.394.

18.

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF.

Cell. 2009 Nov 13;139(4):719-30. doi: 10.1016/j.cell.2009.10.015. Epub 2009 Nov 5.

19.

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.

Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan MR, Berger JM.

Elife. 2013 Oct 8;2:e00882. doi: 10.7554/eLife.00882.

20.

The origin recognition complex in human diseases.

Shen Z.

Biosci Rep. 2013 Jun 11;33(3). pii: e00044. doi: 10.1042/BSR20130036. Review.

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