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Items: 1 to 20 of 107

1.

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.

Roep BO, Solvason N, Gottlieb PA, Abreu JRF, Harrison LC, Eisenbarth GS, Yu L, Leviten M, Hagopian WA, Buse JB, von Herrath M, Quan J, King RS, Robinson WH, Utz PJ, Garren H; BHT-3021 Investigators, Steinman L.

Sci Transl Med. 2013 Jun 26;5(191):191ra82. doi: 10.1126/scitranslmed.3006103.

2.

Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform.

Gottlieb P, Utz PJ, Robinson W, Steinman L.

Clin Immunol. 2013 Dec;149(3):297-306. doi: 10.1016/j.clim.2013.08.010. Epub 2013 Sep 1. Review.

3.

Immunotherapy: Modified proinsulin to treat T1DM.

Geach T.

Nat Rev Endocrinol. 2013 Sep;9(9):503. doi: 10.1038/nrendo.2013.133. Epub 2013 Jul 16. No abstract available.

PMID:
23856817
4.

Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model.

Yu C, Burns JC, Robinson WH, Utz PJ, Ho PP, Steinman L, Frey AB.

J Diabetes Res. 2016;2016:9083103. doi: 10.1155/2016/9083103. Epub 2016 Mar 16.

5.

Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes.

Pathiraja V, Kuehlich JP, Campbell PD, Krishnamurthy B, Loudovaris T, Coates PT, Brodnicki TC, O'Connell PJ, Kedzierska K, Rodda C, Bergman P, Hill E, Purcell AW, Dudek NL, Thomas HE, Kay TW, Mannering SI.

Diabetes. 2015 Jan;64(1):172-82. doi: 10.2337/db14-0858. Epub 2014 Aug 25.

6.

Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study.

Thrower SL, James L, Hall W, Green KM, Arif S, Allen JS, Van-Krinks C, Lozanoska-Ochser B, Marquesini L, Brown S, Wong FS, Dayan CM, Peakman M.

Clin Exp Immunol. 2009 Feb;155(2):156-65. doi: 10.1111/j.1365-2249.2008.03814.x. Epub 2008 Nov 20.

7.

CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes.

Sarikonda G, Pettus J, Phatak S, Sachithanantham S, Miller JF, Wesley JD, Cadag E, Chae J, Ganesan L, Mallios R, Edelman S, Peters B, von Herrath M.

J Autoimmun. 2014 May;50:77-82. doi: 10.1016/j.jaut.2013.12.003. Epub 2013 Dec 30.

PMID:
24387802
8.

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW.

J Clin Invest. 2006 Dec;116(12):3258-65.

9.

Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.

Griffin AC, Zhao W, Wegmann KW, Hickley WF.

Am J Pathol. 1995 Sep;147(3):845-57.

10.

Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice.

Sarikonda G, Sachithanantham S, Manenkova Y, Kupfer T, Posgai A, Wasserfall C, Bernstein P, Straub L, Pagni PP, Schneider D, Calvo TR, Coulombe M, Herold K, Gill RG, Atkinson M, Nepom G, Ehlers M, Staeva T, Garren H, Steinman L, Chan AC, von Herrath M.

PLoS One. 2013;8(2):e54712. doi: 10.1371/journal.pone.0054712. Epub 2013 Feb 6.

11.

IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse.

Fuchs YF, Adler K, Lindner A, Karasinsky A, Wilhelm C, Weigelt M, Balke H, Förtsch K, Mortler-Hildebrandt LF, Harlan DM, Pechhold K, Ziegler AG, Bonifacio E.

Clin Exp Immunol. 2014 May;176(2):199-206. doi: 10.1111/cei.12263.

12.

Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients.

Toma A, Haddouk S, Briand JP, Camoin L, Gahery H, Connan F, Dubois-Laforgue D, Caillat-Zucman S, Guillet JG, Carel JC, Muller S, Choppin J, Boitard C.

Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10581-6. Epub 2005 Jul 19.

13.

The sentinel role of CD8 T cells in regulating CD4 T cell responses to proinsulin in beta-islet cell autoimmunity.

Batarelo V, Durinovic-Belló I.

Ann N Y Acad Sci. 2008 Dec;1150:270-2. doi: 10.1196/annals.1447.047.

PMID:
19120311
14.

[Recombination of RegIII-proinsulin-pBudCE4.1 plasmid and its therapeutic effect on STZ-induced type 1 diabetes mellitus].

Hou WR, Xie SN, Lu JL, Xi W, Luo X, Xiang M.

Yao Xue Xue Bao. 2010 Aug;45(8):987-94. Chinese.

PMID:
21351584
15.

The diabetogenic, insulin-specific CD8 T cell response primed in the experimental autoimmune diabetes model in RIP-B7.1 mice.

Karges W, Rajasalu T, Spyrantis A, Wieland A, Boehm B, Schirmbeck R.

Eur J Immunol. 2007 Aug;37(8):2097-103.

16.

Predominantly recognized proinsulin T helper cell epitopes in individuals with and without islet cell autoimmunity.

Durinovic-Belló I, Boehm BO, Ziegler AG.

J Autoimmun. 2002 Feb;18(1):55-66.

PMID:
11869047
17.

Modulation of Autoimmune T-Cell Memory by Stem Cell Educator Therapy: Phase 1/2 Clinical Trial.

Delgado E, Perez-Basterrechea M, Suarez-Alvarez B, Zhou H, Revuelta EM, Garcia-Gala JM, Perez S, Alvarez-Viejo M, Menendez E, Lopez-Larrea C, Tang R, Zhu Z, Hu W, Moss T, Guindi E, Otero J, Zhao Y.

EBioMedicine. 2015 Nov 5;2(12):2024-36. doi: 10.1016/j.ebiom.2015.11.003. eCollection 2015 Dec.

18.

Protective response against type 1 diabetes in nonobese diabetic mice after coimmunization with insulin and DNA encoding proinsulin.

Zhang W, Jin H, Hu Y, Yu Y, Li X, Ding Z, Kang Y, Wang B.

Hum Gene Ther. 2010 Feb;21(2):171-8. doi: 10.1089/hum.2009.095.

PMID:
19788384
19.

Activation of CD8+ T lymphocytes in insulin-dependent diabetes mellitus.

Togun RA, Resetkova E, Kawai K, Enomoto T, Volpé R.

Clin Immunol Immunopathol. 1997 Mar;82(3):243-9.

PMID:
9073547
20.

Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes.

Narendran P, Williams AJ, Elsegood K, Leech NJ, Dayan CM.

Diabetes Metab Res Rev. 2003 Jan-Feb;19(1):52-9.

PMID:
12592644

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