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Items: 1 to 20 of 104

1.

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32.

Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11565-70. doi: 10.1073/pnas.1302114110. Epub 2013 Jun 24.

2.
3.

Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.

Le NH, Molle V, Eynard N, Miras M, Stella A, Bardou F, Galandrin S, Guillet V, André-Leroux G, Bellinzoni M, Alzari P, Mourey L, Burlet-Schiltz O, Daffé M, Marrakchi H.

J Biol Chem. 2016 Oct 21;291(43):22793-22805. Epub 2016 Sep 2.

PMID:
27590338
4.

The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.

Gavalda S, Léger M, van der Rest B, Stella A, Bardou F, Montrozier H, Chalut C, Burlet-Schiltz O, Marrakchi H, Daffé M, Quémard A.

J Biol Chem. 2009 Jul 17;284(29):19255-64. doi: 10.1074/jbc.M109.006940. Epub 2009 May 12.

5.
6.

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.

Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR Jr, Neiditch MB, Kremer L, Alland D.

Nat Chem Biol. 2013 Aug;9(8):499-506. doi: 10.1038/nchembio.1277. Epub 2013 Jun 16.

7.

Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.

Guillet V, Galandrin S, Maveyraud L, Ladevèze S, Mariaule V, Bon C, Eynard N, Daffé M, Marrakchi H, Mourey L.

J Biol Chem. 2016 Apr 8;291(15):7973-89. doi: 10.1074/jbc.M115.712612. Epub 2016 Feb 21.

8.

The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis.

Léger M, Gavalda S, Guillet V, van der Rest B, Slama N, Montrozier H, Mourey L, Quémard A, Daffé M, Marrakchi H.

Chem Biol. 2009 May 29;16(5):510-9. doi: 10.1016/j.chembiol.2009.03.012.

9.

ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria.

Kurth DG, Gago GM, de la Iglesia A, Bazet Lyonnet B, Lin TW, Morbidoni HR, Tsai SC, Gramajo H.

Microbiology. 2009 Aug;155(Pt 8):2664-75. doi: 10.1099/mic.0.027714-0. Epub 2009 May 7.

10.

Antibacterial drugs: hitting the tuberculosis wall.

Harrison C.

Nat Rev Drug Discov. 2013 Aug;12(8):578-9. doi: 10.1038/nrd4080. No abstract available.

PMID:
23903215
11.

Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.

Barkan D, Liu Z, Sacchettini JC, Glickman MS.

Chem Biol. 2009 May 29;16(5):499-509. doi: 10.1016/j.chembiol.2009.04.001.

12.

Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis.

Schroeder EK, de Souza N, Santos DS, Blanchard JS, Basso LA.

Curr Pharm Biotechnol. 2002 Sep;3(3):197-225. Review.

PMID:
12164478
13.

Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria.

Li W, Gu S, Fleming J, Bi L.

Sci Rep. 2015 Dec 2;5:15493. doi: 10.1038/srep15493.

14.

Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.

Molle V, Gulten G, Vilchèze C, Veyron-Churlet R, Zanella-Cléon I, Sacchettini JC, Jacobs WR Jr, Kremer L.

Mol Microbiol. 2010 Dec;78(6):1591-605. doi: 10.1111/j.1365-2958.2010.07446.x. Epub 2010 Nov 9.

15.

Assay development for identifying inhibitors of the mycobacterial FadD32 activity.

Galandrin S, Guillet V, Rane RS, Léger M, N R, Eynard N, Das K, Balganesh TS, Mourey L, Daffé M, Marrakchi H.

J Biomol Screen. 2013 Jun;18(5):576-87. doi: 10.1177/1087057112474691. Epub 2013 Jan 30.

PMID:
23364516
16.

[Biosynthesis and regulation of mycolic acids in Mycobacterium tuberculosis--a review].

Luo H, Pang L, Xie J.

Wei Sheng Wu Xue Bao. 2012 Feb 4;52(2):146-51. Review. Chinese.

PMID:
22586991
17.

The Molecular Genetics of Mycolic Acid Biosynthesis.

Pawełczyk J, Kremer L.

Microbiol Spectr. 2014 Aug;2(4):MGM2-0003-2013. doi: 10.1128/microbiolspec.MGM2-0003-2013. Review.

PMID:
26104214
18.

Characterization of 7-amino-4-methylcoumarin as an effective antitubercular agent: structure-activity relationships.

Tandon R, Ponnan P, Aggarwal N, Pathak R, Baghel AS, Gupta G, Arya A, Nath M, Parmar VS, Raj HG, Prasad AK, Bose M.

J Antimicrob Chemother. 2011 Nov;66(11):2543-55. doi: 10.1093/jac/dkr355. Epub 2011 Sep 14.

PMID:
21917615
20.

Mycolic acids: deciphering and targeting the Achilles' heel of the tubercle bacillus.

Nataraj V, Varela C, Javid A, Singh A, Besra GS, Bhatt A.

Mol Microbiol. 2015 Oct;98(1):7-16. doi: 10.1111/mmi.13101. Epub 2015 Jul 30. Review.

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