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Items: 1 to 20 of 127


Small GTPase Rab14 down-regulates UT-A1 urea transport activity through enhanced clathrin-dependent endocytosis.

Su H, Liu B, Fröhlich O, Ma H, Sands JM, Chen G.

FASEB J. 2013 Oct;27(10):4100-7. doi: 10.1096/fj.13-229294. Epub 2013 Jun 24.


Depolymerization of cortical actin inhibits UT-A1 urea transporter endocytosis but promotes forskolin-stimulated membrane trafficking.

Xu G, Su H, Carter CB, Fröhlich O, Chen G.

Am J Physiol Cell Physiol. 2012 Apr 1;302(7):C1012-8. doi: 10.1152/ajpcell.00440.2011. Epub 2012 Jan 18.


Internalization of UT-A1 urea transporter is dynamin dependent and mediated by both caveolae- and clathrin-coated pit pathways.

Huang H, Feng X, Zhuang J, Fröhlich O, Klein JD, Cai H, Sands JM, Chen G.

Am J Physiol Renal Physiol. 2010 Dec;299(6):F1389-95. doi: 10.1152/ajprenal.00718.2009. Epub 2010 Sep 22.


Caveolin-1 directly interacts with UT-A1 urea transporter: the role of caveolae/lipid rafts in UT-A1 regulation at the cell membrane.

Feng X, Huang H, Yang Y, Fröhlich O, Klein JD, Sands JM, Chen G.

Am J Physiol Renal Physiol. 2009 Jun;296(6):F1514-20. doi: 10.1152/ajprenal.00068.2009. Epub 2009 Apr 15.


Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cells.

Su H, Carter CB, Laur O, Sands JM, Chen G.

Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1325-32. doi: 10.1152/ajprenal.00248.2012. Epub 2012 Aug 22.


Glycoforms of UT-A3 urea transporter with poly-N-acetyllactosamine glycosylation have enhanced transport activity.

Su H, Carter CB, Fröhlich O, Cummings RD, Chen G.

Am J Physiol Renal Physiol. 2012 Jul 15;303(2):F201-8. doi: 10.1152/ajprenal.00140.2012. Epub 2012 Apr 25.


Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.

Feng X, Li Z, Du Y, Fu H, Klein JD, Cai H, Sands JM, Chen G.

Am J Physiol Renal Physiol. 2015 Jul 1;309(1):F71-8. doi: 10.1152/ajprenal.00546.2014. Epub 2015 May 20.


The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.

Mistry AC, Mallick R, Fröhlich O, Klein JD, Rehm A, Chen G, Sands JM.

J Biol Chem. 2007 Oct 12;282(41):30097-106. Epub 2007 Aug 16.


Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.

Wang Y, Klein JD, Blount MA, Martin CF, Kent KJ, Pech V, Wall SM, Sands JM.

J Am Soc Nephrol. 2009 Sep;20(9):2018-24. doi: 10.1681/ASN.2008121225. Epub 2009 Aug 6.


Mature N-linked glycans facilitate UT-A1 urea transporter lipid raft compartmentalization.

Chen G, Howe AG, Xu G, Fröhlich O, Klein JD, Sands JM.

FASEB J. 2011 Dec;25(12):4531-9. doi: 10.1096/fj.11-185991. Epub 2011 Sep 29.


New advances in urea transporter UT-A1 membrane trafficking.

Chen G.

Int J Mol Sci. 2013 May 21;14(5):10674-82. doi: 10.3390/ijms140510674. Review.


Activation of the cAMP/PKA pathway induces UT-A1 urea transporter monoubiquitination and targets it for lysosomal degradation.

Su H, Chen M, Sands JM, Chen G.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1775-82. doi: 10.1152/ajprenal.00393.2013. Epub 2013 Oct 16.


Alternative channels for urea in the inner medulla of the rat kidney.

Nawata CM, Dantzler WH, Pannabecker TL.

Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F916-24. doi: 10.1152/ajprenal.00392.2015. Epub 2015 Sep 30.


MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.

Chen G, Huang H, Fröhlich O, Yang Y, Klein JD, Price SR, Sands JM.

Am J Physiol Renal Physiol. 2008 Nov;295(5):F1528-34. doi: 10.1152/ajprenal.90482.2008. Epub 2008 Sep 10.


Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding.

Mistry AC, Mallick R, Klein JD, Sands JM, Fröhlich O.

Am J Physiol Cell Physiol. 2010 Jun;298(6):C1431-7. doi: 10.1152/ajpcell.00497.2009. Epub 2010 Mar 24.


Modulation of kidney urea transporter UT-A3 activity by alpha2,6-sialylation.

Qian X, Sands JM, Song X, Chen G.

Pflugers Arch. 2016 Jul;468(7):1161-70. doi: 10.1007/s00424-016-1802-0. Epub 2016 Mar 14.


Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells.

Klein JD, Blount MA, Fröhlich O, Denson CE, Tan X, Sim JH, Martin CF, Sands JM.

Am J Physiol Renal Physiol. 2010 Apr;298(4):F935-40. doi: 10.1152/ajprenal.00682.2009. Epub 2010 Jan 13.


Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts.

Klein JD, Fröhlich O, Blount MA, Martin CF, Smith TD, Sands JM.

J Am Soc Nephrol. 2006 Oct;17(10):2680-6. Epub 2006 Sep 7.


Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation.

Blount MA, Mistry AC, Fröhlich O, Price SR, Chen G, Sands JM, Klein JD.

Am J Physiol Renal Physiol. 2008 Jul;295(1):F295-9. doi: 10.1152/ajprenal.00102.2008. Epub 2008 May 21.


Characterization of mouse urea transporters UT-A1 and UT-A2.

Fenton RA, Stewart GS, Carpenter B, Howorth A, Potter EA, Cooper GJ, Smith CP.

Am J Physiol Renal Physiol. 2002 Oct;283(4):F817-25.

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