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Items: 1 to 20 of 116


Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics.

Xue L, Geahlen RL, Tao WA.

Mol Cell Proteomics. 2013 Oct;12(10):2969-80. doi: 10.1074/mcp.O113.027722. Epub 2013 Jun 22.


Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.

Xue L, Wang WH, Iliuk A, Hu L, Galan JA, Yu S, Hans M, Geahlen RL, Tao WA.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5615-20. doi: 10.1073/pnas.1119418109. Epub 2012 Mar 26.


Identification of BCAR-1 as a new substrate of Syk tyrosine kinase through a determination of amino acid sequence preferences surrounding the substrate tyrosine residue.

Kim JY, Huh K, Jung R, Kim TJ.

Immunol Lett. 2011 Mar 30;135(1-2):151-7. doi: 10.1016/j.imlet.2010.10.016. Epub 2010 Oct 31.


Identification of Direct Kinase Substrates via Kinase Assay-Linked Phosphoproteomics.

Xue L, Arrington JV, Tao WA.

Methods Mol Biol. 2016;1355:263-73. doi: 10.1007/978-1-4939-3049-4_18.


Identification of extracellular signal-regulated kinase 1 (ERK1) direct substrates using stable isotope labeled kinase assay-linked phosphoproteomics.

Xue L, Wang P, Cao P, Zhu JK, Tao WA.

Mol Cell Proteomics. 2014 Nov;13(11):3199-210. doi: 10.1074/mcp.O114.038588. Epub 2014 Jul 14.


New approach for analysis of the phosphotyrosine proteome and its application to the chicken B cell line, DT40.

Zolodz MD, Wood KV, Regnier FE, Geahlen RL.

J Proteome Res. 2004 Jul-Aug;3(4):743-50.


Molecular mechanism of the Syk activation switch.

Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.

J Biol Chem. 2008 Nov 21;283(47):32650-9. doi: 10.1074/jbc.M806340200. Epub 2008 Sep 25.


A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition.

Lipchik AM, Killins RL, Geahlen RL, Parker LL.

Biochemistry. 2012 Sep 25;51(38):7515-24. doi: 10.1021/bi300970h. Epub 2012 Sep 12.


Specific visualization and identification of phosphoproteome in gels.

Wang L, Pan L, Tao WA.

Anal Chem. 2014 Jul 15;86(14):6741-7. doi: 10.1021/ac501641u. Epub 2014 Jun 30.


Phosphoproteomic analysis of Syk kinase signaling in human cancer cells reveals its role in cell-cell adhesion.

Larive RM, Urbach S, Poncet J, Jouin P, Mascré G, Sahuquet A, Mangeat PH, Coopman PJ, Bettache N.

Oncogene. 2009 Jun 18;28(24):2337-47. doi: 10.1038/onc.2009.99. Epub 2009 May 4.


Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers.

Jayasundera KB, Iliuk AB, Nguyen A, Higgins R, Geahlen RL, Tao WA.

Anal Chem. 2014 Jul 1;86(13):6363-71. doi: 10.1021/ac500599r. Epub 2014 Jun 20.


Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells.

Gioia R, Leroy C, Drullion C, Lagarde V, Etienne G, Dulucq S, Lippert E, Roche S, Mahon FX, Pasquet JM.

Blood. 2011 Aug 25;118(8):2211-21. doi: 10.1182/blood-2010-10-313692. Epub 2011 Jul 5.


Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells.

Fernandez JA, Keshvara LM, Peters JD, Furlong MT, Harrison ML, Geahlen RL.

J Biol Chem. 1999 Jan 15;274(3):1401-6.


An osteoclastic protein-tyrosine phosphatase regulates the β3-integrin, syk, and shp1 signaling through respective src-dependent phosphorylation in osteoclasts.

Lau KH, Stiffel V, Amoui M.

Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1676-86. doi: 10.1152/ajpcell.00042.2012. Epub 2012 Mar 28.


Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit.

Yu S, Huang H, Iliuk A, Wang WH, Jayasundera KB, Tao WA, Post CB, Geahlen RL.

J Biol Chem. 2013 Apr 12;288(15):10870-81. doi: 10.1074/jbc.M112.426130. Epub 2013 Feb 27.


Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling.

Keshvara LM, Isaacson CC, Yankee TM, Sarac R, Harrison ML, Geahlen RL.

J Immunol. 1998 Nov 15;161(10):5276-83.


Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation.

Sanderson MP, Wex E, Kono T, Uto K, Schnapp A.

Mol Immunol. 2010 Nov-Dec;48(1-3):171-8. doi: 10.1016/j.molimm.2010.08.012. Epub 2010 Sep 15.


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