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Items: 1 to 20 of 157

1.

Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody.

Kimoto T, Horibata K, Chikura S, Hashimoto K, Itoh S, Sanada H, Muto S, Uno Y, Yamada M, Honma M.

Mutat Res. 2013 Aug 15;755(2):126-34. doi: 10.1016/j.mrgentox.2013.06.006. Epub 2013 Jun 20.

PMID:
23792374
2.

The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: Summary of the MMS/JEMS-collaborative study across 16 laboratories using 24 chemicals.

Kimoto T, Horibata K, Miura D, Chikura S, Okada Y, Ukai A, Itoh S, Nakayama S, Sanada H, Koyama N, Muto S, Uno Y, Yamamoto M, Suzuki Y, Fukuda T, Goto K, Wada K, Kyoya T, Shigano M, Takasawa H, Hamada S, Adachi H, Uematsu Y, Tsutsumi E, Hori H, Kikuzuki R, Ogiwara Y, Yoshida I, Maeda A, Narumi K, Fujiishi Y, Morita T, Yamada M, Honma M.

Mutat Res. 2016 Nov 15;811:3-15. doi: 10.1016/j.mrgentox.2016.10.003. Epub 2016 Oct 21.

3.

International Pig-a gene mutation assay trial: evaluation of transferability across 14 laboratories.

Dertinger SD, Phonethepswath S, Weller P, Nicolette J, Murray J, Sonders P, Vohr HW, Shi J, Krsmanovic L, Gleason C, Custer L, Henwood A, Sweder K, Stankowski LF Jr, Roberts DJ, Giddings A, Kenny J, Lynch AM, Defrain C, Nesslany F, van der Leede BJ, Van Doninck T, Schuermans A, Tanaka K, Hiwata Y, Tajima O, Wilde E, Elhajouji A, Gunther WC, Thiffeault CJ, Shutsky TJ, Fiedler RD, Kimoto T, Bhalli JA, Heflich RH, MacGregor JT.

Environ Mol Mutagen. 2011 Dec;52(9):690-8. doi: 10.1002/em.20672. Epub 2011 Sep 11.

PMID:
21910140
4.

Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes.

Kimoto T, Chikura S, Suzuki K, Kobayashi Xm, Itano Y, Horibata K, Honma M, Dobrovolsky VN, Heflich RH, Miura D, Kasahara Y.

Environ Mol Mutagen. 2011 Dec;52(9):774-83.

PMID:
22167888
5.

Effective use of the Pig-a gene mutation assay for mutagenicity screening: measuring CD59-deficient red blood cells in rats treated with genotoxic chemicals.

Kimoto T, Chikura S, Suzuki-Okada K, Kobayashi XM, Itano Y, Miura D, Kasahara Y.

J Toxicol Sci. 2012;37(5):943-55.

6.

Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea.

Miura D, Dobrovolsky VN, Kimoto T, Kasahara Y, Heflich RH.

Mutat Res. 2009 Jun-Jul;677(1-2):86-92. doi: 10.1016/j.mrgentox.2009.05.014. Epub 2009 Jun 6.

PMID:
19501187
7.

The rat Pig-a assay using an erythroid HIS49 antibody in a single dose study of isopropyl p-toluenesulfonate.

Chikura S, Okada Y, Kimoto T, Kaneko H, Miura D, Kasahara Y.

Mutat Res. 2016 Nov 15;811:110-116. doi: 10.1016/j.mrgentox.2016.04.005. Epub 2016 Apr 14.

PMID:
27931803
8.

Report on stage III Pig-a mutation assays using benzo[a]pyrene.

Bhalli JA, Shaddock JG, Pearce MG, Dobrovolsky VN, Cao X, Heflich RH, Vohr HW.

Environ Mol Mutagen. 2011 Dec;52(9):731-7. doi: 10.1002/em.20675. Epub 2011 Aug 29.

PMID:
22052432
9.

Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a, micronucleus and Comet assays integrated into 28-day repeat dose studies.

Shi J, Krsmanovic L, Bruce S, Kelly T, Paranjpe M, Szabo K, Arevalo M, Atta-Safoh S, Debelie F, LaForce MK, Sly J, Springer S.

Environ Mol Mutagen. 2011 Dec;52(9):711-20. doi: 10.1002/em.20678. Epub 2011 Oct 4.

PMID:
21976072
10.

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.

Cammerer Z, Bhalli JA, Cao X, Coffing SL, Dickinson D, Dobo KL, Dobrovolsky VN, Engel M, Fiedler RD, Gunther WC, Heflich RH, Pearce MG, Shaddock JG, Shutsky T, Thiffeault CJ, Schuler M.

Environ Mol Mutagen. 2011 Dec;52(9):721-30.

PMID:
22167886
11.

Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats.

Dobrovolsky VN, Boctor SY, Twaddle NC, Doerge DR, Bishop ME, Manjanatha MG, Kimoto T, Miura D, Heflich RH, Ferguson SA.

Environ Mol Mutagen. 2010 Mar;51(2):138-45. doi: 10.1002/em.20519.

PMID:
19658152
12.

Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.

Dertinger SD, Phonethepswath S, Weller P, Avlasevich S, Torous DK, Mereness JA, Bryce SM, Bemis JC, Bell S, Portugal S, Aylott M, MacGregor JT.

Environ Mol Mutagen. 2011 Dec;52(9):748-55. doi: 10.1002/em.20671. Epub 2011 Aug 29.

PMID:
22052433
13.

Evaluation of single-dose RBC Pig-a and PIGRET assays in detecting the mutagenicity of thiotepa in rats.

Tsutsumi E, Momonami A, Hori H, Kitagawa Y.

Mutat Res. 2016 Nov 15;811:123-128. doi: 10.1016/j.mrgentox.2016.06.002. Epub 2016 Jul 7.

PMID:
27931805
14.

Evaluation of the in vivo mutagenicity of melamine by the RBC Pig-a assay and PIGRET assay.

Kyoya T, Hori M, Terada M.

Mutat Res. 2016 Nov 15;811:43-48. doi: 10.1016/j.mrgentox.2016.04.003. Epub 2016 May 10.

PMID:
27931813
15.

Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.

Stankowski LF Jr, Roberts DJ, Chen H, Lawlor T, McKeon M, Murli H, Thakur A, Xu Y.

Environ Mol Mutagen. 2011 Dec;52(9):738-47. doi: 10.1002/em.20692. Epub 2011 Oct 21.

PMID:
22020836
16.

Pyrene did not induce gene mutation in red blood cell Pig-a assay and PIGRET assay in rats.

Yoshida I, Matsumoto A, Sakai Y, Harada Y, Hashizume T.

Mutat Res. 2016 Nov 15;811:49-53. doi: 10.1016/j.mrgentox.2016.04.007. Epub 2016 Apr 20.

PMID:
27931814
17.

Evaluation of the RBC Pig-a assay and the PIGRET assay using benzo[a]pyrene in rats.

Kikuzuki R, Sato H, Fujiwara A, Takahashi T, Ogiwara Y, Sugiura M.

Mutat Res. 2016 Nov 15;811:86-90. doi: 10.1016/j.mrgentox.2016.03.010. Epub 2016 Mar 26.

PMID:
27931821
18.

Detection of Pig-a gene mutants in rat peripheral blood following a single urethane treatment: A comparison of the RBC Pig-a and PIGRET assays.

Narumi K, Fujiishi Y, Okada E, Ohyama W.

Mutat Res. 2016 Nov 15;811:129-134. doi: 10.1016/j.mrgentox.2016.02.004. Epub 2016 Mar 2.

PMID:
27931806
19.

Results of rat Pig-a/PIGRET assay with a single dose regimen of 1,3-propane sultone and 2-acetyl aminofluorene.

Shigano M, Ishii N, Takashima R, Harada H, Takasawa H, Hamada S.

Mutat Res. 2016 Nov 15;811:75-79. doi: 10.1016/j.mrgentox.2016.04.001. Epub 2016 Apr 3.

PMID:
27931819
20.

Evaluation for a mutagenicity of aristolochic acid by Pig-a and PIGRET assays in rats.

Koyama N, Yonezawa Y, Nakamura M, Sanada H.

Mutat Res. 2016 Nov 15;811:80-85. doi: 10.1016/j.mrgentox.2015.12.004. Epub 2015 Dec 23.

PMID:
27931820

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