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Items: 1 to 20 of 85

1.

PACAP induces the dimerization of PAC1 on the nucleus associated with the cAMP increase in the nucleus.

Yu R, Zhong J, Li M, Guo X, Zhang H, Chen J.

Neurosci Lett. 2013 Aug 9;549:92-6. doi: 10.1016/j.neulet.2013.06.015. Epub 2013 Jun 20.

PMID:
23792266
2.

The N-terminal HSDCIF motif is required for cell surface trafficking and dimerization of family B G protein coupled receptor PAC1.

Yu R, Guo X, Zhong J, Li M, Zeng Z, Zhang H.

PLoS One. 2012;7(12):e51811. doi: 10.1371/journal.pone.0051811. Epub 2012 Dec 21.

3.

A novel cyclopeptide from the cyclization of PACAP(1-5) with potent activity towards PAC1 attenuates STZ-induced diabetes.

Yu R, Wang J, Li J, Wang Y, Zhang H, Chen J, Huang L, Liu X.

Peptides. 2010 Jun;31(6):1062-7. doi: 10.1016/j.peptides.2010.03.008. Epub 2010 Mar 20.

PMID:
20307608
4.

Doxycycline exerted neuroprotective activity by enhancing the activation of neuropeptide GPCR PAC1.

Yu R, Zheng L, Cui Y, Zhang H, Ye H.

Neuropharmacology. 2016 Apr;103:1-15. doi: 10.1016/j.neuropharm.2015.11.032. Epub 2015 Dec 15.

PMID:
26700245
5.

GnRH-induced PACAP and PAC1 receptor expression in pituitary gonadotrophs: a possible role in the regulation of gonadotropin subunit gene expression.

Purwana IN, Kanasaki H, Oride A, Mijiddorj T, Shintani N, Hashimoto H, Baba A, Miyazaki K.

Peptides. 2010 Sep;31(9):1748-55. doi: 10.1016/j.peptides.2010.05.012. Epub 2010 May 27.

PMID:
20553777
6.
7.

PACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling.

May V, Buttolph TR, Girard BM, Clason TA, Parsons RL.

Am J Physiol Cell Physiol. 2014 Jun 1;306(11):C1068-79. doi: 10.1152/ajpcell.00001.2014. Epub 2014 Apr 2.

8.

Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus.

Costa L, Santangelo F, Li Volsi G, Ciranna L.

Hippocampus. 2009 Jan;19(1):99-109. doi: 10.1002/hipo.20488.

PMID:
18727050
9.

Pituitary adenylate cyclase-activating polypeptide and PACAP receptor expression and function in the rat adrenal gland.

Mazzocchi G, Malendowicz LK, Neri G, Andreis PG, Ziolkowska A, Gottardo L, Nowak KW, Nussdorfer GG.

Int J Mol Med. 2002 Mar;9(3):233-43.

PMID:
11836629
10.

Pituitary adenylate cyclase-activating polypeptide directly modulates the activity of proopiomelanocortin neurons in the rat arcuate nucleus.

Mounien L, Bizet P, Boutelet I, Gourcerol G, Fournier A, Vaudry H, Jégou S.

Neuroscience. 2006 Nov 17;143(1):155-63. Epub 2006 Sep 8.

PMID:
16962718
11.
12.

Alternative splicing of the pituitary adenylate cyclase-activating polypetide (PACAP) receptor contributes to function of PACAP-27.

Ushiyama M, Ikeda R, Yoshida M, Mori K, Kangawa K, Sugawara H, Inoue K, Yamada K, Miyata A.

J Mol Neurosci. 2010 Nov;42(3):341-8. doi: 10.1007/s12031-010-9385-2. Epub 2010 May 15.

PMID:
20473586
13.

Maxadilan specifically interacts with PAC1 receptor, which is a dominant form of PACAP/VIP family receptors in cultured rat cortical neurons.

Tatsuno I, Uchida D, Tanaka T, Saeki N, Hirai A, Saito Y, Moro O, Tajima M.

Brain Res. 2001 Jan 19;889(1-2):138-48.

PMID:
11166697
14.
15.

PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells.

Le SV, Yamaguchi DJ, McArdle CA, Tachiki K, Pisegna JR, Germano P.

Regul Pept. 2002 Nov 15;109(1-3):115-25.

PMID:
12409223
16.

Novel stable PACAP analogs with potent activity towards the PAC1 receptor.

Bourgault S, Vaudry D, Botia B, Couvineau A, Laburthe M, Vaudry H, Fournier A.

Peptides. 2008 Jun;29(6):919-32. doi: 10.1016/j.peptides.2008.01.022. Epub 2008 Feb 13.

PMID:
18353507
17.

Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells: consequences for signaling by VIP and PACAP.

Lutz EM, Ronaldson E, Shaw P, Johnson MS, Holland PJ, Mitchell R.

Mol Cell Neurosci. 2006 Feb;31(2):193-209. Epub 2005 Oct 14.

PMID:
16226889
18.

Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP.

Dejda A, Bourgault S, Doan ND, Létourneau M, Couvineau A, Vaudry H, Vaudry D, Fournier A.

Biochimie. 2011 Apr;93(4):669-77. doi: 10.1016/j.biochi.2010.12.010. Epub 2010 Dec 23.

PMID:
21185349
19.

Impaired somatodendritic responses to pituitary adenylate cyclase-activating polypeptide (PACAP) of supraoptic neurones in PACAP type I -receptor deficient mice.

Jamen F, Alonso G, Shibuya I, Widmer H, Vacher CM, Calas A, Bockaert J, Brabet P, Dayanithi G.

J Neuroendocrinol. 2003 Sep;15(9):871-81.

PMID:
12899682
20.

Pituitary adenylyl cyclase-activating polypeptide (PACAP) and its receptor (PAC1-R) are positioned to modulate afferent signaling in the cochlea.

Drescher MJ, Drescher DG, Khan KM, Hatfield JS, Ramakrishnan NA, Abu-Hamdan MD, Lemonnier LA.

Neuroscience. 2006 Sep 29;142(1):139-64. Epub 2006 Jul 31.

PMID:
16876955

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