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Disruption of mycobactin biosynthesis leads to attenuation of Mycobacterium tuberculosis for growth and virulence.

Reddy PV, Puri RV, Chauhan P, Kar R, Rohilla A, Khera A, Tyagi AK.

J Infect Dis. 2013 Oct 15;208(8):1255-65. doi: 10.1093/infdis/jit250. Epub 2013 Jun 20.


Iron storage proteins are essential for the survival and pathogenesis of Mycobacterium tuberculosis in THP-1 macrophages and the guinea pig model of infection.

Reddy PV, Puri RV, Khera A, Tyagi AK.

J Bacteriol. 2012 Feb;194(3):567-75. doi: 10.1128/JB.05553-11. Epub 2011 Nov 18.


Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis.

Madigan CA, Martinot AJ, Wei JR, Madduri A, Cheng TY, Young DC, Layre E, Murry JP, Rubin EJ, Moody DB.

PLoS Pathog. 2015 Mar 27;11(3):e1004792. doi: 10.1371/journal.ppat.1004792. eCollection 2015 Mar.


Deciphering the genes involved in pathogenesis of Mycobacterium tuberculosis.

Singh R, Singh A, Tyagi AK.

Tuberculosis (Edinb). 2005 Sep-Nov;85(5-6):325-35. Epub 2005 Oct 25.


The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages.

De Voss JJ, Rutter K, Schroeder BG, Su H, Zhu Y, Barry CE 3rd.

Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1252-7.


Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis.

Malhotra V, Sharma D, Ramanathan VD, Shakila H, Saini DK, Chakravorty S, Das TK, Li Q, Silver RF, Narayanan PR, Tyagi JS.

FEMS Microbiol Lett. 2004 Feb 16;231(2):237-45.


The polyphosphate kinase gene ppk2 is required for Mycobacterium tuberculosis inorganic polyphosphate regulation and virulence.

Chuang YM, Belchis DA, Karakousis PC.

MBio. 2013 May 21;4(3):e00039-13. doi: 10.1128/mBio.00039-13.


Analyses of MbtB, MbtE, and MbtF suggest revisions to the mycobactin biosynthesis pathway in Mycobacterium tuberculosis.

McMahon MD, Rush JS, Thomas MG.

J Bacteriol. 2012 Jun;194(11):2809-18. doi: 10.1128/JB.00088-12. Epub 2012 Mar 23.


Examination of Mycobacterium tuberculosis sigma factor mutants using low-dose aerosol infection of guinea pigs suggests a role for SigC in pathogenesis.

Karls RK, Guarner J, McMurray DN, Birkness KA, Quinn FD.

Microbiology. 2006 Jun;152(Pt 6):1591-600.


Participation of fad and mbt genes in synthesis of mycobactin in Mycobacterium smegmatis.

LaMarca BB, Zhu W, Arceneaux JE, Byers BR, Lundrigan MD.

J Bacteriol. 2004 Jan;186(2):374-82.


Requirement of gene fadD33 for the growth of Mycobacterium tuberculosis in a hepatocyte cell line.

Rindi L, Bonanni D, Lari N, Garzelli C.

New Microbiol. 2004 Apr;27(2):125-31.


Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs.

Singh R, Rao V, Shakila H, Gupta R, Khera A, Dhar N, Singh A, Koul A, Singh Y, Naseema M, Narayanan PR, Paramasivan CN, Ramanathan VD, Tyagi AK.

Mol Microbiol. 2003 Nov;50(3):751-62.


Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro.

Downing KJ, Mischenko VV, Shleeva MO, Young DI, Young M, Kaprelyants AS, Apt AS, Mizrahi V.

Infect Immun. 2005 May;73(5):3038-43.


Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs.

Singh A, Gupta R, Vishwakarma RA, Narayanan PR, Paramasivan CN, Ramanathan VD, Tyagi AK.

J Bacteriol. 2005 Jun;187(12):4173-86.


A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion.

Gao LY, Guo S, McLaughlin B, Morisaki H, Engel JN, Brown EJ.

Mol Microbiol. 2004 Sep;53(6):1677-93.


Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells.

Velmurugan K, Chen B, Miller JL, Azogue S, Gurses S, Hsu T, Glickman M, Jacobs WR Jr, Porcelli SA, Briken V.

PLoS Pathog. 2007 Jul;3(7):e110.


Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis.

Madigan CA, Cheng TY, Layre E, Young DC, McConnell MJ, Debono CA, Murry JP, Wei JR, Barry CE 3rd, Rodriguez GM, Matsunaga I, Rubin EJ, Moody DB.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1257-62. doi: 10.1073/pnas.1109958109. Epub 2012 Jan 9.

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