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Functional significance of glutamate-cysteine ligase modifier for erythrocyte survival in vitro and in vivo.

Föller M, Harris IS, Elia A, John R, Lang F, Kavanagh TJ, Mak TW.

Cell Death Differ. 2013 Oct;20(10):1350-8. doi: 10.1038/cdd.2013.70. Epub 2013 Jun 21.


Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response.

Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP.

J Biol Chem. 2002 Dec 20;277(51):49446-52. Epub 2002 Oct 15.


Glutamate Cysteine Ligase Modifier Subunit (Gclm) Null Mice Have Increased Ovarian Oxidative Stress and Accelerated Age-Related Ovarian Failure.

Lim J, Nakamura BN, Mohar I, Kavanagh TJ, Luderer U.

Endocrinology. 2015 Sep;156(9):3329-43. doi: 10.1210/en.2015-1206. Epub 2015 Jun 17.


Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice.

Nakamura BN, Mohar I, Lawson GW, Cortés MM, Hoang YD, Ortiz L, Patel R, Rau BA, McConnachie LA, Kavanagh TJ, Luderer U.

Toxicol Sci. 2012 Mar;126(1):227-41. doi: 10.1093/toxsci/kfs017. Epub 2012 Jan 17.


Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.

Chen Y, Shertzer HG, Schneider SN, Nebert DW, Dalton TP.

J Biol Chem. 2005 Oct 7;280(40):33766-74. Epub 2005 Aug 4.


Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.

Kann S, Estes C, Reichard JF, Huang MY, Sartor MA, Schwemberger S, Chen Y, Dalton TP, Shertzer HG, Xia Y, Puga A.

Toxicol Sci. 2005 Oct;87(2):365-84. Epub 2005 Jul 13.


Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury.

Kobayashi T, Watanabe Y, Saito Y, Fujioka D, Nakamura T, Obata JE, Kitta Y, Yano T, Kawabata K, Watanabe K, Mishina H, Ito S, Kugiyama K.

Cardiovasc Res. 2010 Mar 1;85(4):785-95. doi: 10.1093/cvr/cvp342. Epub 2009 Oct 16.


In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective.

Ortiz L, Nakamura B, Li X, Blumberg B, Luderer U.

Toxicol Lett. 2013 Nov 25;223(2):260-7. doi: 10.1016/j.toxlet.2013.09.017. Epub 2013 Oct 6.


Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress.

Solis WA, Dalton TP, Dieter MZ, Freshwater S, Harrer JM, He L, Shertzer HG, Nebert DW.

Biochem Pharmacol. 2002 May 1;63(9):1739-54.


Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress.

Krzywanski DM, Dickinson DA, Iles KE, Wigley AF, Franklin CC, Liu RM, Kavanagh TJ, Forman HJ.

Arch Biochem Biophys. 2004 Mar 1;423(1):116-25.


Molecular cloning and analysis of Ancylostoma ceylanicum glutamate-cysteine ligase.

Wiśniewski M, Lapiński M, Zdziarska A, Długosz E, Bąska P.

Mol Biochem Parasitol. 2014 Aug;196(1):12-20. doi: 10.1016/j.molbiopara.2014.07.003. Epub 2014 Aug 1.


Glutamate cysteine ligase (GCL) transgenic and gene-targeted mice for controlling glutathione synthesis.

Mohar I, Botta D, White CC, McConnachie LA, Kavanagh TJ.

Curr Protoc Toxicol. 2009 Feb;Chapter 6:Unit6.16. doi: 10.1002/0471140856.tx0616s39.


Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice.

Nakamura BN, Fielder TJ, Hoang YD, Lim J, McConnachie LA, Kavanagh TJ, Luderer U.

Endocrinology. 2011 Jul;152(7):2806-15. doi: 10.1210/en.2011-0207. Epub 2011 May 10.


Modulating GSH synthesis using glutamate cysteine ligase transgenic and gene-targeted mice.

Botta D, White CC, Vliet-Gregg P, Mohar I, Shi S, McGrath MB, McConnachie LA, Kavanagh TJ.

Drug Metab Rev. 2008;40(3):465-77. doi: 10.1080/03602530802186587 . Review.


α-Lipoic acid protects against the oxidative stress and cytotoxicity induced by cadmium in HepG2 cells through regenerating glutathione regulated by glutamate-cysteine ligase.

Xu Y, Zhou X, Shi C, Wang J, Wu Z.

Toxicol Mech Methods. 2015;25(8):596-603. doi: 10.3109/15376516.2015.1044150. Epub 2015 Sep 12.


Glutathione (GSH) and the GSH synthesis gene Gclm modulate plasma redox and vascular responses to acute diesel exhaust inhalation in mice.

Weldy CS, Luttrell IP, White CC, Morgan-Stevenson V, Cox DP, Carosino CM, Larson TV, Stewart JA, Kaufman JD, Kim F, Chitaley K, Kavanagh TJ.

Inhal Toxicol. 2013 Jul;25(8):444-54. doi: 10.3109/08958378.2013.801004. Epub 2013 Jul 1.


Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits.

Sikalidis AK, Mazor KM, Lee JI, Roman HB, Hirschberger LL, Stipanuk MH.

Amino Acids. 2014 May;46(5):1285-96. doi: 10.1007/s00726-014-1687-1. Epub 2014 Feb 21.


Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration.

Liang LP, Kavanagh TJ, Patel M.

Toxicol Sci. 2013 Aug;134(2):366-73. doi: 10.1093/toxsci/kft112. Epub 2013 May 23.


Lipid metabolism and body composition in Gclm(-/-) mice.

Kendig EL, Chen Y, Krishan M, Johansson E, Schneider SN, Genter MB, Nebert DW, Shertzer HG.

Toxicol Appl Pharmacol. 2011 Dec 15;257(3):338-48. doi: 10.1016/j.taap.2011.09.017. Epub 2011 Sep 24.


Rapid activation of glutamate cysteine ligase following oxidative stress.

Krejsa CM, Franklin CC, White CC, Ledbetter JA, Schieven GL, Kavanagh TJ.

J Biol Chem. 2010 May 21;285(21):16116-24. doi: 10.1074/jbc.M110.116210. Epub 2010 Mar 23.

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