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Items: 1 to 20 of 102


Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6.

Wilderman PR, Shah MB, Jang HH, Stout CD, Halpert JR.

J Am Chem Soc. 2013 Jul 17;135(28):10433-40. doi: 10.1021/ja403042k. Epub 2013 Jul 3.


Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.

Shah MB, Wilderman PR, Liu J, Jang HH, Zhang Q, Stout CD, Halpert JR.

Mol Pharmacol. 2015 Apr;87(4):649-59. doi: 10.1124/mol.114.097014. Epub 2015 Jan 13.


Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains.

Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR.

Mol Pharmacol. 2011 Dec;80(6):1047-55. doi: 10.1124/mol.111.074427. Epub 2011 Aug 29.


Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR.

Mol Pharmacol. 2010 Apr;77(4):529-38. doi: 10.1124/mol.109.062570. Epub 2010 Jan 8.


The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes.

Jang HH, Davydov DR, Lee GY, Yun CH, Halpert JR.

Arch Biochem Biophys. 2014 Mar 1;545:100-7. doi: 10.1016/ Epub 2014 Jan 18.


Molecular recognition in (+)-alpha-pinene oxidation by cytochrome P450cam.

Bell SG, Chen X, Sowden RJ, Xu F, Williams JN, Wong LL, Rao Z.

J Am Chem Soc. 2003 Jan 22;125(3):705-14.


Structure-function analysis of cytochromes P450 2B.

Zhao Y, Halpert JR.

Biochim Biophys Acta. 2007 Mar;1770(3):402-12. Epub 2006 Jul 22. Review.


Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.

Liu J, Shah MB, Zhang Q, Stout CD, Halpert JR, Wilderman PR.

Biochemistry. 2016 Apr 5;55(13):1997-2007. doi: 10.1021/acs.biochem.5b01330. Epub 2016 Mar 24.


Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules.

Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR.

Biochemistry. 2012 Sep 18;51(37):7225-38. doi: 10.1021/bi300894z. Epub 2012 Sep 4.


Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity.

Bumpus NN, Hollenberg PF.

Mol Pharmacol. 2008 Oct;74(4):990-9. doi: 10.1124/mol.108.048637. Epub 2008 Jul 11.


Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry.

Muralidhara BK, Halpert JR.

Drug Metab Rev. 2007;39(2-3):539-56. Review.


Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

Zhao Y, White MA, Muralidhara BK, Sun L, Halpert JR, Stout CD.

J Biol Chem. 2006 Mar 3;281(9):5973-81. Epub 2005 Dec 21.


Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.

Zhao Y, Sun L, Muralidhara BK, Kumar S, White MA, Stout CD, Halpert JR.

Biochemistry. 2007 Oct 16;46(41):11559-67. Epub 2007 Sep 22.


Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.

Kumar S, Zhao Y, Sun L, Negi SS, Halpert JR, Muralidhara BK.

Mol Pharmacol. 2007 Nov;72(5):1191-9. Epub 2007 Aug 22.


Thermodynamic fidelity of the mammalian cytochrome P450 2B4 active site in binding substrates and inhibitors.

Muralidhara BK, Sun L, Negi S, Halpert JR.

J Mol Biol. 2008 Mar 14;377(1):232-45. doi: 10.1016/j.jmb.2007.12.068. Epub 2008 Jan 5.


Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6.

Dicke KE, Skrlin SM, Murphy SE.

Drug Metab Dispos. 2005 Dec;33(12):1760-4. Epub 2005 Sep 20.


Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6.

Kent UM, Sridar C, Spahlinger G, Hollenberg PF.

Chem Res Toxicol. 2008 Oct;21(10):1956-63. doi: 10.1021/tx800138v. Epub 2008 Aug 26.


Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling.

Shebley M, Kent UM, Ballou DP, Hollenberg PF.

Drug Metab Dispos. 2009 Apr;37(4):745-52. doi: 10.1124/dmd.108.024661. Epub 2009 Jan 14.


Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs.

Talakad JC, Kumar S, Halpert JR.

Drug Metab Dispos. 2009 Mar;37(3):644-50. doi: 10.1124/dmd.108.023655. Epub 2008 Dec 12.

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