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The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation.

Smits BM, Haag JD, Rissman AI, Sharma D, Tran A, Schoenborn AA, Baird RC, Peiffer DS, Leinweber DQ, Muelbl MJ, Meilahn AL, Eichelberg MR, Leng N, Kendziorski C, John MC, Powers PA, Alexander CM, Gould MN.

PLoS Genet. 2013 Jun;9(6):e1003549. doi: 10.1371/journal.pgen.1003549. Epub 2013 Jun 13.


The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions.

Smits BM, Sharma D, Samuelson DJ, Woditschka S, Mau B, Haag JD, Gould MN.

Breast Cancer Res. 2011 Aug 16;13(4):R81. doi: 10.1186/bcr2933.


Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.

denDekker AD, Xu X, Vaughn MD, Puckett AH, Gardner LL, Lambring CJ, Deschenes L, Samuelson DJ.

Cancer Res. 2012 Nov 15;72(22):6002-12. doi: 10.1158/0008-5472.CAN-12-0748. Epub 2012 Sep 19.


Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5.

Schaffer BS, Leland-Wavrin KM, Kurz SG, Colletti JA, Seiler NL, Warren CL, Shull JD.

Cancer Prev Res (Phila). 2013 Jan;6(1):59-69. doi: 10.1158/1940-6207.CAPR-12-0346-T. Epub 2012 Nov 14.


Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors.

Smart CE, Askarian Amiri ME, Wronski A, Dinger ME, Crawford J, Ovchinnikov DA, Vargas AC, Reid L, Simpson PT, Song S, Wiesner C, French JD, Dave RK, da Silva L, Purdon A, Andrew M, Mattick JS, Lakhani SR, Brown MA, Kellie S.

PLoS One. 2012;7(7):e40742. doi: 10.1371/journal.pone.0040742. Epub 2012 Jul 17.


Congenic rats reveal three independent Copenhagen alleles within the Mcs1 quantitative trait locus that confer resistance to mammary cancer.

Haag JD, Shepel LA, Kolman BD, Monson DM, Benton ME, Watts KT, Waller JL, Lopez-Guajardo CC, Samuelson DJ, Gould MN.

Cancer Res. 2003 Sep 15;63(18):5808-12.


TOX3 is expressed in mammary ER(+) epithelial cells and regulates ER target genes in luminal breast cancer.

Seksenyan A, Kadavallore A, Walts AE, de la Torre B, Berel D, Strom SP, Aliahmad P, Funari VA, Kaye J.

BMC Cancer. 2015 Jan 30;15:22. doi: 10.1186/s12885-015-1018-2.


The Non-coding Mammary Carcinoma Susceptibility Locus, Mcs5c, Regulates Pappa Expression via Age-Specific Chromatin Folding and Allele-Dependent DNA Methylation.

Henning AN, Haag JD, Smits BM, Gould MN.

PLoS Genet. 2016 Aug 18;12(8):e1006261. doi: 10.1371/journal.pgen.1006261. eCollection 2016 Aug.


An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a.

Smits BM, Traun BD, Devries TL, Tran A, Samuelson D, Haag JD, Gould M.

Nucleic Acids Res. 2012 Jan;40(1):132-47. doi: 10.1093/nar/gkr610. Epub 2011 Sep 13.


Validation of six genetic determinants of susceptibility to estrogen-induced mammary cancer in the rat and assessment of their relevance to breast cancer risk in humans.

Colletti JA 2nd, Leland-Wavrin KM, Kurz SG, Hickman MP, Seiler NL, Samanas NB, Eckert QA, Dennison KL, Ding L, Schaffer BS, Shull JD.

G3 (Bethesda). 2014 May 28;4(8):1385-94. doi: 10.1534/g3.114.011163.


A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.

Burleigh A, McKinney S, Brimhall J, Yap D, Eirew P, Poon S, Ng V, Wan A, Prentice L, Annab L, Barrett JC, Caldas C, Eaves C, Aparicio S.

Breast Cancer Res. 2015 Jan 9;17:4. doi: 10.1186/s13058-014-0510-y.


Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene.

Ren X, Graham JC, Jing L, Mikheev AM, Gao Y, Lew JP, Xie H, Kim AS, Shang X, Friedman C, Vail G, Fang MZ, Bromberg Y, Zarbl H.

PLoS One. 2013 Sep 2;8(9):e70930. doi: 10.1371/journal.pone.0070930. eCollection 2013.


Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression.

Chen F, Li A, Gao S, Hollern D, Williams M, Liu F, VanSickle EA, Andrechek E, Zhang C, Yang C, Luo R, Xiao H.

Cell Death Dis. 2014 May 22;5:e1242. doi: 10.1038/cddis.2014.224.


Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein.

Goddio MV, Gattelli A, Slomiansky V, Lacunza E, Gingerich T, Tocci JM, Facchinetti MM, Curino AC, LaMarre J, Abba MC, Kordon EC.

Breast Cancer Res Treat. 2012 Oct;135(3):749-58. doi: 10.1007/s10549-012-2216-0. Epub 2012 Aug 29.


Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.

Cicchini M, Chakrabarti R, Kongara S, Price S, Nahar R, Lozy F, Zhong H, Vazquez A, Kang Y, Karantza V.

Autophagy. 2014;10(11):2036-52. doi: 10.4161/auto.34398. Epub 2014 Oct 30.


Genome-wide analysis of binding sites and direct target genes of the orphan nuclear receptor NR2F1/COUP-TFI.

Montemayor C, Montemayor OA, Ridgeway A, Lin F, Wheeler DA, Pletcher SD, Pereira FA.

PLoS One. 2010 Jan 27;5(1):e8910. doi: 10.1371/journal.pone.0008910.


c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.

Regan JL, Kendrick H, Magnay FA, Vafaizadeh V, Groner B, Smalley MJ.

Oncogene. 2012 Feb 16;31(7):869-83. doi: 10.1038/onc.2011.289. Epub 2011 Jul 18.


COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration.

Boudot A, Kerdivel G, Lecomte S, Flouriot G, Desille M, Godey F, Leveque J, Tas P, Le Dréan Y, Pakdel F.

BMC Cancer. 2014 Jun 6;14:407. doi: 10.1186/1471-2407-14-407.


Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression.

Veillet AL, Haag JD, Remfert JL, Meilahn AL, Samuelson DJ, Gould MN.

Cancer Prev Res (Phila). 2011 Jan;4(1):97-106. doi: 10.1158/1940-6207.CAPR-10-0187.

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